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Chlordiazepoxide

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Identification
Molecular formula
C16H14ClN3O
CAS number
58-25-3
IUPAC name
9-chloro-5-[2-(dimethylamino)ethyl]-11H-benzo[b][1,4]benzodiazepin-6-one
State
State
Chlordiazepoxide is in a solid state at room temperature.
Melting point (Celsius)
230.00
Melting point (Kelvin)
503.15
Boiling point (Celsius)
545.30
Boiling point (Kelvin)
818.45
General information
Molecular weight
299.76g/mol
Molar mass
299.7700g/mol
Density
1.4350g/cm3
Appearence
Chlordiazepoxide appears as a white to off-white crystalline powder.
Comment on solubility

Solubility of 9-chloro-5-[2-(dimethylamino)ethyl]-11H-benzo[b][1,4]benzodiazepin-6-one

The solubility of 9-chloro-5-[2-(dimethylamino)ethyl]-11H-benzo[b][1,4]benzodiazepin-6-one in various solvents is a critical aspect to consider for its applications and behavior in different environments. Here are some important points regarding its solubility:

  • Polarity: The presence of both chloro and dimethylamino groups suggests that the compound may exhibit varying degrees of polarity, affecting its solubility in polar versus non-polar solvents.
  • Solvent Interaction: It is expected to be soluble in organic solvents such as methanol and dimethyl sulfoxide (DMSO), but might show limited solubility in water due to its hydrophobic aromatic structure.
  • pH Dependence: As a basic compound, solubility can be influenced by pH. Under acidic conditions, the dimethylamino group may become protonated, potentially increasing solubility in aqueous solutions.
  • Temperature Influence: Generally, increased temperature may enhance solubility for many organic compounds, which can also be the case for this compound.

In conclusion, the solubility of 9-chloro-5-[2-(dimethylamino)ethyl]-11H-benzo[b][1,4]benzodiazepin-6-one is multifaceted, influenced by solvent choice, temperature, and environmental pH. Understanding these characteristics is vital for its practical uses in pharmaceuticals and related fields.

Interesting facts

Interesting Facts about 9-Chloro-5-[2-(dimethylamino)ethyl]-11H-benzo[b][1,4]benzodiazepin-6-one

This compound is a member of the benzodiazepine family, which is known for its diverse effects on the central nervous system. Benzodiazepines are primarily recognized for their sedative, anxiolytic, and muscle-relaxant properties.

Chemical Characteristics

  • Structure: The unique structure of this compound includes a 9-chloro substitution, which can influence its pharmacological properties compared to other benzodiazepines.
  • Side Chain: The presence of the dimethylamino ethyl side chain contributes to its potential potency and binding affinity for GABAA receptors.
  • Receptor Interaction: It is suggested that compounds with similar structures can act as agonists at the benzodiazepine site, enhancing the inhibitory effects of gamma-aminobutyric acid (GABA).

Applications

Due to its structural and chemical properties, this compound has potential implications in various fields:

  • Pharmaceutical Research: Investigations into its effects may lead to the development of new therapeutic agents for treating anxiety disorders and insomnia.
  • Psychoactive Studies: Research into its effects on mood and cognition could provide insights into treatment options for mood disorders.
  • Neuroscience: As a model compound, it may be used to study mechanisms of action of various CNS-active molecules.

Fun Fact

This compound illustrates the diversity found within the benzodiazepine class, showcasing the intricate balance between structure and function in medicinal chemistry. As noted by chemists, "The right side group can make all the difference in pharmacological activity and efficacy."

In summary, 9-chloro-5-[2-(dimethylamino)ethyl]-11H-benzo[b][1,4]benzodiazepin-6-one is more than just a chemical entity; it embodies the ongoing quest in the field of pharmacology to understand and manipulate interactions within the nervous system for better therapeutic outcomes.

Synonyms
BRN 0895284
5H-Dibenzo(b,e)(1,4)diazepin-11-one, 10,11-dihydro-3-chloro-10-(2-(dimethylamino)ethyl)-
1668-69-5
DTXSID90168188
10,11-Dihydro-11-oxo-5H-dibenzo(b,e)(1,4)diazepine, 3-chloro-10-(2-(dimethylamino)ethyl)-
DTXCID0090679