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Loperamide

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Identification
Molecular formula
C29H33ClN2O2
CAS number
34552-83-5
IUPAC name
9-ethyl-3-[o-tolyl(phenyl)methoxy]-9-azabicyclo[3.3.1]nonane
State
State

Loperamide is in a solid state at room temperature.

Melting point (Celsius)
222.00
Melting point (Kelvin)
495.15
Boiling point (Celsius)
443.00
Boiling point (Kelvin)
716.15
General information
Molecular weight
477.05g/mol
Molar mass
477.0480g/mol
Density
1.1640g/cm3
Appearence

Loperamide typically appears as a white or almost white crystalline powder. Depending on humidity conditions, it can exhibit a slightly different opacity.

Comment on solubility

Solubility of 9-ethyl-3-[o-tolyl(phenyl)methoxy]-9-azabicyclo[3.3.1]nonane

The solubility of 9-ethyl-3-[o-tolyl(phenyl)methoxy]-9-azabicyclo[3.3.1]nonane presents an intriguing study due to its complex molecular structure. Here are some key points to consider:

  • Polar vs Nonpolar: The compound features both polar and nonpolar characteristics. The presence of the methoxy group and the aromatic rings introduces polarity, while the bicyclic structure usually adds nonpolar attributes.
  • Solvent Interaction: Generally, this compound is expected to have better solubility in organic solvents such as ethanol or dichloromethane rather than in polar solvents like water, due to its hydrophobic parts.
  • Molecular Size: The bulkiness of the bicyclic system may also limit its solubility in certain media, where steric hindrance could affect how well it interacts with solvent molecules.

Overall, while the precise solubility details may require empirical testing, one can hypothesize that its solubility is influenced significantly by its molecular structure, polarity, and the nature of the solvent. As a rule of thumb, “like dissolves like” often applies, underscoring the importance of understanding the nature of both the compound and the solvent in solubility assessments.

Interesting facts

Interesting Facts About 9-ethyl-3-[o-tolyl(phenyl)methoxy]-9-azabicyclo[3.3.1]nonane

The compound 9-ethyl-3-[o-tolyl(phenyl)methoxy]-9-azabicyclo[3.3.1]nonane belongs to a fascinating class of compounds known as bicyclic amines, which are of significant interest in medicinal chemistry. Here are some intriguing aspects of this compound:

  • Structural Complexity: This compound features a unique bicyclic structure, providing a highly branched molecular framework that can influence its biological activity significantly.
  • Potential Therapeutic Applications: Such compounds are often studied for their potential role in drug development, particularly in treating neurological disorders and pain management due to their interaction with the central nervous system.
  • Chirality: The stereochemistry of bicyclic compounds like this one can lead to different pharmacological effects. Understanding the chirality is essential to optimizing efficacy and minimizing side effects.

As a scientist, you might appreciate how the interplay between structure and function drives research in this domain. The presence of functional groups, such as the methoxy and tolyl moieties, can greatly alter the physicochemical properties and biological activity of the compound:

  • Variability in Activity: Slight structural variations can lead to significant differences in how the compound interacts with biological targets.
  • Drug Design Innovations: Researchers often look at these types of compounds to inspire novel drugs that can address unmet medical needs due to their diverse action mechanisms.

In summary, 9-ethyl-3-[o-tolyl(phenyl)methoxy]-9-azabicyclo[3.3.1]nonane represents more than just a chemical structure; it is a gateway into the fascinating world of drug discovery and molecular interactions. As you delve deeper into the study of such compounds, remember the profound implications their structures can have on their function and potential impact on human health.

Synonyms
KSD 2363
BRN 1549768
6605-97-6
N-Ethyl-norgranatanol-3,alpha-(2-methyl-benzhydryl)aether [German]
9-Ethyl-3-alpha-(o-methyldiphenylmethoxy)-9-azabicyclo(3.3.1)nonane
9-AZABICYCLO(3.3.1)NONANE, 9-ETHYL-3-alpha-(o-METHYLDIPHENYLMETHOXY)-
N-Ethyl-norgranatanol-3,alpha-(2-methyl-benzhydryl)aether
DTXSID00984518
9-ETHYL-3-[(2-METHYLPHENYL)(PHENYL)METHOXY]-9-AZABICYCLO[3.3.1]NONANE