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Dexamethasone

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Identification
Molecular formula
C22H29FO5
CAS number
50-02-2
IUPAC name
9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one
State
State

At room temperature, dexamethasone is a solid, existing in a crystalline form. It is often used in powdered form for its pharmaceutical applications.

Melting point (Celsius)
262.00
Melting point (Kelvin)
535.15
Boiling point (Celsius)
500.00
Boiling point (Kelvin)
773.15
General information
Molecular weight
392.47g/mol
Molar mass
392.4650g/mol
Density
1.2110g/cm3
Appearence

Dexamethasone is typically a white to off-white crystalline powder. It is odorless and stable under normal conditions. Due to its appearance, it is sometimes used in medical and pharmaceutical settings as a reference compound.

Comment on solubility

Solubility of 9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one

The solubility of chemical compounds can offer profound insights into their potential applications and behaviors in various environments. For the compound 9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one (C22H29FO5), we observe several important characteristics pertaining to its solubility:

  • Solubility in Water: Generally, compounds with a high molecular weight and complex hydrophobic structures tend to show reduced solubility in polar solvents such as water. In this case, the presence of multiple hydrophobic segments suggests limited aqueous solubility.
  • Solubility in Organic Solvents: Non-polar organic solvents like ethanol or methanol may provide better solubility due to the hydrophobic nature of the cyclopenta[a]phenanthrene core.
  • pH Dependence: The functional groups present in the compound, especially hydroxyl groups, may impart some pH-dependent solubility characteristics, where solubility can increase in more basic or acidic conditions.
  • Potential Applications: Understanding solubility is crucial for formulation in drug development, as it impacts bioavailability and delivery mechanisms.

In conclusion, the solubility profile of C22H29FO5 invites a deeper examination of its behavior in various environments. As emphasized, "like dissolves like," and thus appreciating both hydrophilic and hydrophobic interactions is fundamental to predicting its solubility behavior.

Interesting facts

Interesting Facts about 9-Fluoro-11-Hydroxy-17-(2-Hydroxyacetyl)-10,13,16-Trimethyl-7,8,11,12,14,15,16,17-Octahydro-6H-Cyclopenta[a]Phenanthren-3-One

This compound, a fluorinated derivative of a steroid, embodies intriguing structural and functional properties that make it a subject of interest in both synthetic chemistry and pharmacology. Here are some noteworthy points about this chemical:

  • Fluorinated Compound: The presence of a fluorine atom introduces unique electronic properties, enhancing the compound's receptor binding affinity, which is vital in drug design.
  • Hydroxy Functional Groups: The hydroxy groups contribute to the compound's polarity and solubility, influencing its interaction with biological systems.
  • Structural Complexity: With multiple methyl groups and a complex bicyclic framework, this compound showcases the intricate nature of steroid derivatives.
  • Biological Activity: Compounds like this one often display significant biological activity, which can include steroid-like properties important for diverse medicinal applications.
  • Potential Applications: Researchers explore fluorinated steroids for their applications in treatments for hormonal disorders, anti-inflammatory agents, and even as potential anti-cancer therapies.

As scientists continue to investigate the multifaceted roles of such complex molecules, the potential for new therapeutic avenues remains vast and exciting. 9-Fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one stands as a testament to the intricate relationship between structure and function in the realm of organic and medicinal chemistry.

Synonyms
Topisolon
Desoxymetasone
9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one
Deoxymethasone
17 Desoxymethasone
17-Desoxymethasone
Topicorte
Stidex
A 41304
DTXSID80859356
VWVSBHGCDBMOOT-UHFFFAOYSA-N
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,21-dihydroxy-16-methyl-, (11.beta.,16.alpha.)-
9-Fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
(11.beta.,16.alpha.)-9-Fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione, (11.beta.,16.alpha.)- #
9-Fluoro-11.beta.,21-dihydroxy-16.alpha.-methylpregna-1,4-diene-3,20-dione
Pregna-1,4-diene-3,20-dione, 9-fluoro-11.beta.,21-dihydroxy-16.alpha.-methyl-