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Fluocinolone acetonide

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Identification
Molecular formula
C24H30F1O6
CAS number
67-73-2
IUPAC name
9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
State
State

Fluocinolone acetonide is typically found in a solid state at room temperature. It is stable under recommended storage conditions, although it may degrade upon exposure to light.

Melting point (Celsius)
272.00
Melting point (Kelvin)
545.15
Boiling point (Celsius)
307.50
Boiling point (Kelvin)
580.65
General information
Molecular weight
452.50g/mol
Molar mass
452.4950g/mol
Density
1.3794g/cm3
Appearence

Fluocinolone acetonide is a white to off-white crystalline powder. It is odorless and tasteless, allowing for versatile use in pharmaceutical formulations.

Comment on solubility

Solubility of 9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

The solubility of the compound C24H30F1O6, also known as 9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one, is an important consideration in its applications. Understanding its solubility helps not only in formulation but also in predicting its behavior in biological systems. Here are key points to consider regarding its solubility:

  • Polarity: The presence of multiple hydroxyl (-OH) groups suggests that this compound is likely to exhibit some degree of hydrophilicity, potentially allowing it to dissolve in polar solvents.
  • Solvent Interaction: This compound might have varied solubility depending on the solvent. It could be expected to have lower solubility in non-polar solvents due to the hydrophilic nature of its functional groups.
  • pH Dependence: The solubility can also be influenced by the solution pH, especially considering the presence of hydroxyl groups which may ionize under certain conditions.
  • Structural Complexity: The intricate structure of the compound can hinder solubility in some cases, meaning that while it is soluble in some solvents, it may not dissolve easily in others.

In summary, while the precise solubility of C24H30F1O6 can vary based on external conditions and the specific medium, the number of hydroxyl groups tends to indicate a favorable interaction with polar solvents. Understanding these properties is essential for effective application in research and industry.

Interesting facts

Interesting Facts about 9-Fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

This fascinating compound is part of a larger family of steroids, which play critical roles in biological systems. Here are some key points about this particular steroid:

  • Fluorine Substitution: The presence of fluorine in its structure not only influences the lipophilicity but also impacts the biological activity, making it an interesting subject for research in medicinal chemistry.
  • Hydroxy Groups: With three hydroxyl (–OH) groups, this compound exhibits strong potential for interactions with biological molecules, increasing its ability to participate in various biochemical pathways.
  • Significance in Medicine: Compounds like this are often explored for therapeutic applications, particularly in hormone replacement therapies and anti-inflammatory treatments.
  • Structural Complexity: The complex arrangement of rings in its structure is typical of steroids, offering a myriad of possible modifications that can enhance its efficacy and reduce side effects.
  • Potential Research Implications: Understanding the synthesis and reactions of such compounds can lead to the development of new drugs that target specific ailments, showcasing the importance of synthetic organic chemistry in medicinal development.

In essence, studying 9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one can offer valuable insights into both the synthetic pathways of complex organic molecules and their potential applications in the field of health sciences. As a chemist, one is often reminded that the structure of a compound dictates its reactivity and potential, making this steroid not just a chemical formula, but a beacon of possibility in drug discovery.


Synonyms
Mycolog
Kenacort-AG
Cinolone
Omicilon
SCHEMBL4759998
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
GFNANZIMVAIWHM-UHFFFAOYSA-N
ALBB-025802
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11.beta.,16.alpha.)-
AKOS015998418
1-fluoro-13,14,17-trihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7. 0.0<2,7>.0<11,15>]heptadeca-3,6-dien-5-one
9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-
(11.beta.,16.alpha.)-9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
11.beta.,16.alpha.,17.alpha.,21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, (11.beta.,16.alpha.)- #
9-Fluoro-11-.beta.,16-.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17.alpha.,21-tetrahydroxypregna-1,4-diene-3,20-dione
Pregna-1,4-diene-3,20-dione, 9-fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-