Skip to main content

Galantamine

ADVERTISEMENT
Identification
Molecular formula
C17H21NO3
CAS number
357-70-0
IUPAC name
9-methoxy-1,2,3,4,4a,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol
State
State

Galantamine is typically found in solid form at room temperature.

Melting point (Celsius)
126.00
Melting point (Kelvin)
399.20
Boiling point (Celsius)
407.10
Boiling point (Kelvin)
680.30
General information
Molecular weight
287.36g/mol
Molar mass
287.3540g/mol
Density
1.3000g/cm3
Appearence

Galantamine is a white to off-white fine crystalline powder.

Comment on solubility

Solubility of 9-Methoxy-1,2,3,4,4a,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol (C17H21NO3)

The solubility of 9-methoxy-1,2,3,4,4a,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol is an important property to consider for applications in various fields, particularly in pharmaceuticals. It can be summarized through the following aspects:

  • Solvent Type: The compound is expected to exhibit moderate solubility in organic solvents like ethanol, methanol, and dimethyl sulfoxide (DMSO).
  • Polarity Influences: Due to the presence of methoxy and hydroxyl groups, the overall polarity of the molecule affects its solubility. The hydroxyl (-OH) group can form hydrogen bonds with solvents, enhancing solubility in polar solvents.
  • Temperature Dependence: Like many organic compounds, solubility often increases with temperature, which can be crucial for formulation purposes.
  • pH Considerations: The solubility might significantly vary with pH changes, especially if the compound can undergo protonation or deprotonation.

In conclusion, understanding the solubility characteristics of this compound aids in optimizing its use in formulations, allowing for greater effectiveness in desired applications. As always, empirical solubility tests should complement theoretical assessments to achieve accurate solubility profiles.

Interesting facts

Interesting Facts about 9-Methoxy-1,2,3,4,4a,7,7a,13-Octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol

This unique compound belongs to the family of isoquinolines, which are known for their *diverse biological activities*. Its complex structure features multiple fused rings and functional groups, making it a subject of interest in organic chemistry and medicinal research.

Biological Significance

  • Alkaloid Derivatives: Compounds like this often possess alkaloid properties, which can lead to potential therapeutic applications.
  • Research Potential: Its intricate arrangement allows for exploration in pharmacological contexts, particularly in drug development.
  • Natural Sources: Similar compounds are found in various plants and have been used traditionally in herbal medicine.

Chemical Characteristics

The functional groups present contribute to its ability to interact with biological systems. The *methoxy group* is well-known for enhancing solubility and modulating activity in pharmacologically relevant compounds.

Research and Applications

  • Anticancer Potential: Isoquinoline derivatives are being studied for their ability to inhibit tumor growth.
  • Neurological Effects: Some studies suggest that related compounds may exhibit neuroprotective properties.
  • Novel Syntheses: The methods developed for synthesizing such complex structures can advance the field of organic synthesis.

In conclusion, 9-methoxy-1,2,3,4,4a,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol exemplifies the fascinating interplay between molecular structure and function, sparking curiosity and innovation in chemical research.

Synonyms
N-Norcodeine
Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-, (5.alpha.,6.alpha.)-
SCHEMBL120271
7,8-Didehydro-4,5-.alpha.-epoxy-3-methoxymorphinan-6-.alpha.-ol
Morphinan-6.alpha.-ol, 7,8-didehydro-4,5.alpha.-epoxy-3-methoxy-
(5.alpha.,6.alpha.)-7,8-Didehydro-4,5-epoxy-3-methoxymorphinan-6-ol
DTXSID80859376
3-methoxy-7,8-didehydro-4,5-epoxymorphinan-6-ol