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Noscapine

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Identification
Molecular formula
C22H23NO7
CAS number
128-62-1
IUPAC name
9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol
State
State
Noscapine is typically found as a solid at room temperature, appearing as a crystalline powder, indicating its stable nature in usual atmospheric conditions. This makes it easy to handle and utilize in various applications, particularly in medicinal fields.
Melting point (Celsius)
176.00
Melting point (Kelvin)
449.15
Boiling point (Celsius)
438.30
Boiling point (Kelvin)
711.45
General information
Molecular weight
413.48g/mol
Molar mass
413.4770g/mol
Density
1.2200g/cm3
Appearence

Noscapine appears as a white or slightly off-white crystalline powder or needles. It is often found in this powdered form for medical or research purposes.

Comment on solubility

Solubility of 9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol

The solubility of the compound 9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol (C22H23NO7) reflects its unique chemical structure and functionality. Understanding solubility is crucial for various applications in pharmaceuticals and chemistry. Here are some key points to consider:

  • Solvent Compatibility: This compound may exhibit varying solubility in organic solvents such as ethanol, methanol, or dichloromethane, depending on the polarity of the solvent.
  • Hydrophilicity vs Hydrophobicity: The presence of hydroxyl (-OH) groups typically increases a compound's hydrophilicity, potentially enhancing its solubility in water.
  • Temperature Effects: Solubility can also be temperature-dependent; increasing temperature may improve solubility in some solvents.
  • pH Influence: The pH of the solution might affect the ionization of the hydroxyl groups, thereby influencing solubility.

In general, one can say that **understanding the solubility dynamics** of such complex organic compounds is vital for their practical applications. A thorough exploration of experimental conditions can yield valuable insights into the solubility properties of C22H23NO7.

Interesting facts

Interesting Facts about 9-Methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol

This intriguing compound, featuring a complex molecular structure, belongs to a class of organic molecules that captivate chemists and pharmacologists alike. Here are some fascinating insights:

  • Structural Complexity: The compound showcases a unique fusion of benzofuro and isoquinoline moieties, contributing to its structural diversity, which presents both challenges and opportunities in synthesis and characterization.
  • Bioactivity Potential: Many compounds similar in structure have shown promise in biological activity, making this one a candidate for further research in medicinal chemistry. Studies may reveal potential therapeutic applications, especially in the realms of neuroscience and oncology.
  • Natural Occurrence: Compounds introducing elements like methoxy and hydro groups are often inspired by or derived from natural products, hinting at their possible roles in plant interaction or defense mechanisms.
  • Synthetic Route Exploration: The complexity often necessitates innovative synthetic pathways involving multiple steps, allowing for the exploration of reaction mechanisms. This can teach upcoming chemists a great deal about organic synthesis.
  • Spectroscopy and Analysis: Due to its unique structure, identifying this compound using techniques such as NMR (Nuclear Magnetic Resonance) and MS (Mass Spectrometry) provides engaging case studies for chemistry students.

In summary, the exploration of 9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol not only opens doors to understanding complex organic chemistry but also holds potential implications for future drug discovery and environmental chemistry.

Synonyms
6-Isocodeine
3-methoxy-17-methyl-7,8-didehydro-4,5-epoxymorphinan-6-ol
9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol
9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro(3,2-e)isoquinolin-7-ol
Oprea1_828621
CHEMBL612012
SCHEMBL10064330
BDBM82266
Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5.alpha.,6.alpha.)-
Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5.alpha.,6.beta.)-
HQB84434
PDSP1_001535
PDSP2_001519
STL372754
AKOS040894257
NSC_223652
CAS_29485-83-4
DB-055413
L000781
(5?,6?)-7,8-Didehydro-4,5-epoxy-3-(methoxy-d3)-17-(methyl-d3)morphinan-6-ol
Morphinan-6.alpha.-ol, 7,8-didehydro-4,5.alpha.-epoxy-3-methoxy-17-methyl-