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Dexamethasone

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Identification
Molecular formula
C22H29FO5
CAS number
50-02-2
IUPAC name
(9R,11S)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
State
State

At room temperature, dexamethasone is in a solid state, commonly encountered as a crystalline powder.

Melting point (Celsius)
262.00
Melting point (Kelvin)
535.15
Boiling point (Celsius)
159.00
Boiling point (Kelvin)
432.15
General information
Molecular weight
392.46g/mol
Molar mass
392.4640g/mol
Density
1.2190g/cm3
Appearence

Dexamethasone is typically a white to off-white crystalline powder. It is odorless and has a bitter taste. The crystalline nature gives it a shiny, reflective appearance.

Comment on solubility

Solubility of (9R,11S)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

The solubility of this intricate compound is influenced by a variety of factors, such as temperature, pH, and the presence of other solutes. Generally, the solubility characteristics can be summarized as follows:

  • Water solubility: This compound is likely to exhibit low solubility in water due to its hydrophobic regions stemming from its complex polycyclic structure.
  • Organic solvents: It may find greater solubility in organic solvents such as ethanol or dimethyl sulfoxide (DMSO), which can solvate organic molecules better.
  • Influence of functional groups: The presence of hydroxyl groups may aid solubility in alcohols, while the fluorine atom can influence polarity and interactions with solvents.

In practice, it is essential to conduct empirical solubility tests under controlled conditions, as theoretical predictions may vary based on the physical state and purity of the compound. As noted in chemical literature, "The structure dictates the solubility"! Therefore, each unique structural feature can significantly alter the dissolution dynamics and must be accounted for in applications.


Interesting facts

Interesting Facts about (9R,11S)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

This complex chemical compound belongs to a fascinating category of compounds known as synthetic steroids. These substances are structurally similar to naturally occurring hormones and can exhibit a variety of biological activities. Here are some noteworthy aspects of this compound:

  • Steroidal Structure: The compound contains fused ring systems that are characteristic of steroids, providing it with unique chemical properties and high biological activity.
  • Fluorine Substitution: The presence of the fluorine atom enhances the compound's stability and bioactivity, making it potentially more effective in pharmacological applications.
  • Hydroxyl Groups: The hydroxyl (-OH) groups lend the molecule polar characteristics, which can influence how it interacts with biological systems and receptors.
  • Relevance in Medicine: Similar compounds are often studied for their therapeutic implications, particularly in areas like hormone replacement therapy, anti-inflammatory treatments, and cancer therapies.
  • Biological Activity: There is ongoing research into compounds such as this one regarding their role in modulating metabolic processes and their potential effects on various health conditions.

In summary, the intricate structure and diverse functionalities of (9R,11S)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one warrant attention from both researchers and healthcare professionals looking to explore the boundaries of synthetic steroid research. As we delve deeper into understanding such compounds, we may unlock new possibilities for innovative treatments.