Skip to main content

Fluocinolone acetonide

ADVERTISEMENT
Identification
Molecular formula
C24H30F O6
CAS number
67-73-2
IUPAC name
(9R,16R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one
State
State

At room temperature, fluocinolone acetonide is a solid, consisting of fine crystalline particles. It is stable under normal conditions of use and storage.

Melting point (Celsius)
273.00
Melting point (Kelvin)
546.15
Boiling point (Celsius)
335.00
Boiling point (Kelvin)
608.15
General information
Molecular weight
452.50g/mol
Molar mass
452.4970g/mol
Density
1.2607g/cm3
Appearence

The compound typically appears as a white to off-white crystalline powder. It is known for its fine and homogeneous nature, which facilitates its integration into formulations for medicinal use, particularly in topical applications.

Comment on solubility

Solubility Overview

The solubility of the compound (9R,16R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one can be influenced by several factors. While a detailed solubility profile is typically required for comprehensive understanding, several key points can be highlighted:

  • Polarity: The presence of hydroxyl (-OH) and acetyl (–COCH3) groups suggests that the compound may exhibit some degree of polarity, enabling it to dissolve in polar solvents.
  • Solvent Compatibility: It is likely that this compound will demonstrate better solubility in organic solvents such as ethanol or methanol due to its complex structure. Non-polar solvents may not facilitate effective solubilization.
  • Temperature Impact: As is true for many chemical substances, solubility might increase with temperature; thus, heating the solvent can enhance the dissolution process.
  • pH Influence: The solubility may vary depending on the pH of the solution. Such compounds often showcase altered solubility in acidic or basic environments.

In conclusion, while definitive solubility data would provide clearer insights, the structural characteristics of this compound suggest a moderate solubility that can be tailored through specific solvent selection and environmental conditions. Further experimental evaluation would be essential for precise application and utilization.

Interesting facts

Interesting Facts about (9R,16R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one

This compound, a complex organic molecule, belongs to a class of chemicals known as steroids, which are characterized by their multi-ring structure. It exhibits several notable features:

  • Steroidal Framework: The unique structure of this compound includes a cyclic arrangement that contributes to its biological activity. Steroids are often involved in several physiological processes in living organisms.
  • Fluorination: The presence of a fluorine atom significantly alters the compound's interaction with biological systems, potentially enhancing its therapeutic properties while modifying its pharmacokinetics.
  • Hydroxy Groups: The hydroxy groups within the molecule make it more hydrophilic and can improve solubility, influencing how the compound behaves within biological settings.
  • Acetylation: The 2-hydroxyacetyl side chain is essential for specific interactions with target proteins, which can modulate the compound's functionality in drug design.

This compound showcases the intricate relationship between molecular structure and biological function, making it an exciting subject of study:

“The beauty of chemistry lies in how small changes in molecular structure can yield vastly different properties and functions.”

In summary, the compound is not only a testament to the complexity of organic chemistry but also highlights how modifications at a molecular level can pave the way for innovative therapeutic agents in the field of medicinal chemistry.

Synonyms
Deoxymethasone
Desoxymetasone
CHEMBL16829
SCHEMBL1649772
AKOS015896517