Skip to main content

Dexamethasone

ADVERTISEMENT
Identification
Molecular formula
C22H29Cl2O5
CAS number
50-02-2
IUPAC name
(9R,16R,17R)-9,11-dichloro-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
State
State

At room temperature, dexamethasone is typically found in a solid state, often utilized in powder form for manufacturing pharmaceuticals.

Melting point (Celsius)
262.00
Melting point (Kelvin)
535.15
Boiling point (Celsius)
421.00
Boiling point (Kelvin)
694.15
General information
Molecular weight
392.47g/mol
Molar mass
392.4670g/mol
Density
1.2200g/cm3
Appearence

Dexamethasone typically appears as a white to off-white crystalline powder. It is odorless and stable in its pure form.

Comment on solubility

Solubility of (9R,16R,17R)-9,11-dichloro-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

The solubility of complex organic compounds like (9R,16R,17R)-9,11-dichloro-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one often depends on several factors that include:

  • Polarity: Compounds with polar functional groups generally have better solubility in polar solvents, while non-polar compounds favor non-polar solvents.
  • Molecular Structure: The presence of bulky substituents or rings in the structure can hinder solubility by limiting molecular interactions with the solvent.
  • Temperature: Generally, increasing temperature can enhance solubility for many solid compounds.
  • pH Level: For compounds containing acidic or basic functional groups, altering the pH can affect their ionization and thus solubility.

In the case of this compound, the presence of multiple functional groups such as hydroxy and chloro may provide opportunities for hydrogen bonding in aqueous environments, while hydrophobic regions could impede solubility in polar solvents. Thus, it may exhibit limited solubility in water, requiring the presence of organic solvents for dissolution.

Overall, understanding the solubility characteristics of such compounds is crucial for their application in pharmaceutical formulations, where solubility can directly influence bioavailability and therapeutic efficacy.

Interesting facts

Interesting Facts about (9R,16R,17R)-9,11-Dichloro-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

This complex organic compound belongs to a group of compounds known for their intricate structures and significant biological activities. The detailed configuration of this molecule delivers not just aesthetic impressiveness but also functional versatility. Here are some captivating insights:

  • Hormonal Activity: Compounds similar to this one are often researched for their potential in mimicking or modulating hormonal pathways, making them of particular interest in pharmaceutical development.
  • Chlorinated Compounds: The presence of chlorine atoms indicates a tendency towards greater lipophilicity, often enhancing membrane permeability. This can affect the bioavailability and therapeutic efficacy of the compound.
  • Hydroxyacetyl Group: The incorporation of the 2-hydroxyacetyl moiety may be responsible for interesting interactions within biological systems, suggesting applications in drug formulation or synthesis.
  • Synthetic Potential: The multiple methyl groups present contribute to the overall reactivity patterns observed within laboratories, allowing chemists to explore various synthetic pathways and potential derivatives.
  • Research Significance: Various studies suggest that the structural framework of such compounds aligns with anti-cancer properties and modulating inflammatory responses, hinting at a broad spectrum of therapeutic potentials.

As intriguing as the structural elements of this compound may be, the ongoing research continues to broaden our understanding of its potential applications in both the medicinal chemistry and biological fields. Scientists emphasize that exploring and characterizing such complex compounds is essential for advancing our knowledge and technology in drug discovery.

In the words of a chemist, "The beauty of organic synthesis lies in the complexity and the endless possibilities for discovery!" This compound exemplifies that philosophy as it represents the intersection between structure and function—a vital focus area in current chemical research.

Synonyms
CHEMBL4797802
AKOS024419628
NS00124091
(16alpha)-9,11-dichloro-17,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione