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Triamcinolone acetonide

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Identification
Molecular formula
C24H31FO6
CAS number
76-25-5
IUPAC name
[(9R,17R)-17-acetyl-9-fluoro-11-hydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate
State
State
At room temperature, triamcinolone acetonide is in the form of a solid. It is a powder with no characteristic odor.
Melting point (Celsius)
270.00
Melting point (Kelvin)
543.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
434.50g/mol
Molar mass
434.5030g/mol
Density
1.3000g/cm3
Appearence
Triamcinolone acetonide is a white to cream-colored, crystalline powder.
Comment on solubility

Solubility of [(9R,17R)-17-acetyl-9-fluoro-11-hydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate

The solubility of this complex compound can be intriguing, particularly given its unique structural features that influence its solubility properties. It is important to note the following key points regarding the solubility of such compounds:

  • Polarity: The presence of polar functional groups, such as hydroxyl (–OH) and acetyl (–COCH3), often enhances solubility in polar solvents like water.
  • Hydrophobic Regions: The extensive hydrocarbon framework may create significant hydrophobic characteristics, thereby promoting solubility in non-polar solvents, such as hexane or chloroform.
  • Interactions: The ability to form hydrogen bonds between the compound and solvent molecules can greatly affect solubility, especially in organic solvents.
  • Concentration Dependency: The solubility might vary greatly depending on temperature and concentration, highlighting the need for empirical testing.

In general terms, as with many complex organic compounds, it can be expected that:

  • It may exhibit moderate solubility in polar organic solvents.
  • It could achieve a better solubility profile in non-polar solvents.

Understanding the solubility of this compound requires a comprehensive examination of its interactions with various solvents, making empirical studies vital for elucidating its complete solubility profile.

Interesting facts

Interesting Facts About the Compound

The compound (9R,17R)-17-acetyl-9-fluoro-11-hydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl acetate is a fascinating example in the realm of organic chemistry, particularly in the field of steroid chemistry. Here are some intriguing facts about this compound:

  • Structure and Complexity: This compound features a multi-ring structure typical of steroids, which contributes to its biological activity and potential medicinal properties. The presence of various functional groups, such as acetyl, fluoro, and hydroxy, indicates that it could interact in unique ways within biological systems.
  • Biological Significance: Compounds with similar structures are often associated with important physiological processes. For instance, they may play roles in hormonal functions or as intermediates in biosynthetic pathways.
  • Fluorination Impact: The incorporation of a fluorine atom is significant because fluorinated compounds can exhibit enhanced metabolic stability and bioactivity, making them of great interest for pharmaceutical applications.
  • Medical Research Applications: This compound may be studied for its potential in drug development, particularly in the treatment of conditions influenced by steroid hormones.
  • Synthetic Challenges: The intricate synthesis of this compound showcases the challenges faced by chemists when creating complex molecules, often requiring multi-step processes and careful handling of reactive intermediates.

In summary, this compound not only serves as a model for understanding steroid interactions but also highlights the advancements in synthetic organic chemistry, paving the way for the development of new therapeutic agents. As expressed by a noted chemist, “Chemistry is not just about compounds; it’s about the stories they can tell through their synthesis and application.”