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Estradiol

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Identification
Molecular formula
C18H24O2
CAS number
50-28-2
IUPAC name
(9S,14S)-3,4-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
State
State

At room temperature, estradiol is typically in a solid state, appearing as a crystalline powder. It is not volatile under standard conditions.

Melting point (Celsius)
173.00
Melting point (Kelvin)
446.15
Boiling point (Celsius)
577.30
Boiling point (Kelvin)
850.45
General information
Molecular weight
272.38g/mol
Molar mass
272.3820g/mol
Density
1.1700g/cm3
Appearence

Estradiol is a white or almost white crystalline powder. It is odorless and may appear as small crystals or as a fine powder. Its appearance does not change significantly when exposed to air.

Comment on solubility

Solubility of (9S,14S)-3,4-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one

The solubility of (9S,14S)-3,4-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one is influenced by various factors, such as its molecular structure and functional groups. This compound possesses hydroxyl groups that typically enhance solubility in polar solvents, making it potentially soluble in:

  • Water: Due to the presence of hydroxyl (-OH) groups, which can form hydrogen bonds.
  • Alcohols: Such as ethanol or methanol, where intermolecular interactions further enhance solubility.
  • Organic solvents: Some non-polar organic solvents might show limited solubility due to the hydrophobic portions of the molecule.

However, factors such as temperature, pH, and solvent characteristics play significant roles in solubility behavior. In general, it is crucial to consider:

  1. Molecular weight: The larger the molecule, the lower its solubility might be in non-polar solvents.
  2. Structural elements: The degree of saturation and spatial arrangement can also affect how well the compound interacts with solvents.
  3. Concentration: Higher concentrations may lead to saturation, influencing observed solubility limits.

In conclusion, while (9S,14S)-3,4-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one is expected to have some degree of solubility, conducting empirical solubility tests in various solvents is key to accurately determining its solubility profile.

Interesting facts

Compound Overview: (9S,14S)-3,4-Dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one

This complex chemical compound belongs to a class of organic molecules known for their significant biological activities. Here are some intriguing facts about this intriguing compound:

1. Structural Complexity

  • The compound is characterized by a multi-ring structure that contributes to its unique chemical properties and reactivity.
  • It features intricate stereochemistry, with specific stereocenters that dictate its biological interactions.

2. Biological Relevance

  • Many compounds similar to this one have been explored for their potential therapeutic effects, particularly in oncology and endocrinology.
  • It may play a role in mimicking or modulating the action of steroid hormones due to its structural attributes.

3. Synthetic Approaches

  • The synthesis of this compound is often a challenging task that requires advanced techniques in organic chemistry, including multi-step reactions and specific reaction conditions.
  • As a result, it serves as an excellent example for students studying synthesis and functional group transformations in organic chemistry laboratories.

4. Research Applications

Ongoing research explores the potential of this compound in pharmacology and biochemistry. Scientific studies often focus on:

  • Investigating its interaction with various biological targets.
  • Understanding its mechanism of action at the molecular level.
  • Exploring its potential as a leading compound for drug development.

5. Educational Significance

For chemistry students, studying compounds like this one enhances the understanding of:

  • Natural product chemistry, showcasing how complex molecules are formed in biological systems.
  • The importance of chirality and stereochemical configurations in drug design and efficacy.

In conclusion, (9S,14S)-3,4-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one is a prime example of the intricate relationship between structure and function in chemistry, offering a plethora of opportunities for exploration and research.