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Chloramphenicol

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Identification
Molecular formula
C11H12Cl2N2O5
CAS number
56-75-7
IUPAC name
[(9S,14S,16R,17R)-17-acetyl-6-chloro-10,13,16-trimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
State
State

At room temperature, chloramphenicol is primarily in a solid state. It is typically found as a crystalline substance.

Melting point (Celsius)
149.00
Melting point (Kelvin)
422.15
Boiling point (Celsius)
490.15
Boiling point (Kelvin)
763.30
General information
Molecular weight
355.82g/mol
Molar mass
355.8200g/mol
Density
1.8707g/cm3
Appearence

Chloramphenicol appears as a fine white to gray-white crystalline powder. It is often characterized by its distinct lack of odor.

Comment on solubility

Solubility of the Compound

The solubility of [(9S,14S,16R,17R)-17-acetyl-6-chloro-10,13,16-trimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopentaphenanthren-17-yl] acetate is quite noteworthy. Understanding its solubility characteristics can provide crucial insights, particularly in fields like pharmacology and materials science. Here are some key points:

  • Polar vs Non-Polar: This compound features multiple substituents that may influence its polarity. Given the presence of the acetyl and chloro groups, it is likely to interact variably with polar and non-polar solvents.
  • Common Solvents: It may be soluble in organic solvents such as ethanol, dimethyl sulfoxide (DMSO), and dichloromethane. However, solubility in water is expected to be limited due to its hydrophobic characteristics.
  • Temperature Effects: Like many organic compounds, solubility may increase with temperature. This means higher temperatures could enhance the dissolution rates in suitable solvents.

It is important to note that the solubility of such complex organic compounds can often depend on various factors including:

  • Concentration: Enhanced concentration can lead to precipitation in saturated solutions.
  • pH Levels: The solubility may vary in different pH environments, influencing the ionization of certain functional groups.
  • Presence of Other Chemicals: Co-solvents or stabilizers can significantly alter solubility behavior.

In conclusion, while this compound presents intriguing potential for solubility in specific organic solvents, it is essential to analyze it within the broader context of its chemical interactions and environmental conditions.

Interesting facts

Exploring 17-acetyl-6-chloro-10,13,16-trimethyl-cyclopenta[a]phenanthren-17-yl Acetate

This unique compound is a fascinating example of the complex world of steroids and their derivatives. The structure showcases a rich tapestry of functional groups, including acetyl and chloro moieties, that contribute to its potential biological activity.

Key Features:

  • Structural Diversity: This compound exhibits significant stereochemistry with multiple chiral centers, adding layers of complexity that can influence its pharmacological properties.
  • Potential Applications: Due to its steroid-like structure, it may demonstrate potential in medicinal chemistry, particularly in the realms of hormone replacement therapies or anti-inflammatory treatments.
  • Chloro Substitution: The presence of chlorine is noteworthy; chlorinated compounds often possess unique reactivity patterns and increased lipophilicity, which can enhance their biological activity.
  • Natural Analogues: Many steroids have biological origins, and understanding compounds like this can provide insights into natural products and their modified forms that could lead to novel therapeutics.

As one examines the various functional groups and their placements within the compound, it becomes evident how modifications can significantly affect reactivity and bioactivity. The complexity of this compound is a strong reminder of the intricate relationship between structure and function in chemical compounds. It opens pathways to numerous explorations in organic chemistry, medicinal chemistry, and biochemical applications.

In the words of a renowned chemist, “Understanding the structural nuances of a compound can unlock the door to its potential.” As we delve deeper into compounds like this, we are reminded of the possibilities that lie within the molecular world.