Estradiol | Solubility of Things

Identification

Molecular formula

C₁₈H₂₄O₂

CAS number

50-28-2

IUPAC name

(9S,14S,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

State

At room temperature, estradiol is in a solid state, typically as a crystalline powder.

Melting point (Celsius)

173.00

Melting point (Kelvin)

446.15

Boiling point (Celsius)

417.00

Boiling point (Kelvin)

690.15

General information

Molecular weight

272.38g/mol

Molar mass

272.3830g/mol

Density

1.2000g/cm³

Appearence

Estradiol is typically found in a crystalline form, often appearing as a white odorless powder. It is slightly soluble in water but more soluble in organic solvents such as alcohol or chloroform.

Comment on solubility

Solubility of (9S,14S,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

The solubility of the compound with the formula C₁₈H₂₄O₂, known as (9S,14S,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol, exhibits interesting characteristics due to its unique structural framework. The presence of hydroxyl (–OH) functional groups in the molecule typically enhances its ability to interact with polar solvents.

Here are some key aspects to consider regarding its solubility:

Polar vs. Non-Polar Solvents: This compound is expected to be more soluble in polar solvents like water, methanol, and ethanol, due to the hydroxyl groups facilitating hydrogen bonding.
Hydrophobic Regions: However, the presence of hydrophobic carbon chains limits its overall solubility in water, suggesting a tendency to be more soluble in organic solvents such as chloroform or dichloromethane.
Temperature Dependency: The solubility could also be temperature dependent, often exhibiting increased solubility at elevated temperatures, providing greater kinetic energy to break intermolecular attractions.
Concentration Effects: As concentration increases in a given solvent, the tendency to form clusters may also lead to decreased solubility, a phenomenon known as supersaturation.

In summary, while (9S,14S,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol may possess enhanced solubility due to its functional groups, its hydrophobic structural elements create a complex balance influencing its solubility profile as a whole.

Interesting facts

Interesting Facts about (9S,14S,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

This intriguing compound is a member of the steroid family, which are vital molecules in biology and medicine. Its structure showcases a complex arrangement of rings and functional groups that contribute to its unique properties. Here are some fascinating details about this compound:

Synthetic Pathways: The synthesis of such complex molecules often involves multiple steps and may utilize advanced techniques such as total synthesis or semi-synthesis.
Biological Relevance: Compounds with similar structures often exhibit biological activity, serving as hormones or precursors to biologically active substances. They can influence numerous physiological processes.
Chirality: The stereochemistry of this compound is noteworthy. With multiple chiral centers, its specific spatial arrangement is crucial for its biological interactions—this is a common theme in medicinal chemistry.
Historical Context: Understanding compounds like this has contributed significantly to the fields of pharmacology and endocrinology, helping scientists develop therapies for various hormonal and metabolic disorders.

In conclusion, the (9S,14S,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol serves as a perfect example of the complexity and beauty inherent in organic chemistry. Its study opens doors to potential applications in therapeutic developments that could benefit human health.