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Estradiol

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Identification
Molecular formula
C18H24O2
CAS number
50-28-2
IUPAC name
(9S,14S,17S)-17-ethyl-13-methyl-2,3,4,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol
State
State

Estradiol is generally a solid at room temperature.

Melting point (Celsius)
173.00
Melting point (Kelvin)
446.00
Boiling point (Celsius)
440.00
Boiling point (Kelvin)
713.00
General information
Molecular weight
272.38g/mol
Molar mass
272.3810g/mol
Density
1.1700g/cm3
Appearence

Estradiol appears as a white or almost white crystalline powder. It is odorless and can be acicular (needle-like) in structure. It can also appear in small crystalline forms that are glossy.

Comment on solubility

Solubility of (9S,14S,17S)-17-ethyl-13-methyl-2,3,4,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol

The solubility of (9S,14S,17S)-17-ethyl-13-methyl-2,3,4,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol in various solvents can be explored through several key considerations:

  • Hydrophobic Nature: As a polycyclic compound, its structure suggests a significant hydrophobic character, which often correlates to lower solubility in polar solvents such as water.
  • Solvent Compatibility: Solubility can greatly improve in non-polar solvents, such as:
    • Hexane
    • Benzene
    • Chloroform
  • Temperature Effects: Like many organic compounds, solubility may increase with an increase in temperature, which can affect the compound’s molecular interactions.
  • Functional Groups: The presence of the hydroxyl (-OH) group indicates some potential for enhanced solubility in polar solvents, but the overall large hydrophobic surface area is likely to dominate.

In summary, the solubility of (9S,14S,17S)-17-ethyl-13-methyl-2,3,4,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol will generally favor non-polar solvents, and careful attention should be given to temperature and solvent choice when conducting solubility experiments.

Interesting facts

Interesting Facts about (9S,14S,17S)-17-ethyl-13-methyl-2,3,4,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol

This compound, known as a steroid or steroid-like substance, belongs to a fascinating class of organic molecules that play vital roles in biological processes. Here are some interesting insights:

  • Natural Occurrence: Steroid compounds are often derived from plant and animal sources, contributing significantly to functions such as metabolism, immune response, and growth regulation.
  • Biological Importance: Precursors of hormones like testosterone and progesterone, steroids are essential for sexual development and reproduction in many organisms.
  • Synthesis and Modifications: The complex structure of this compound showcases the versatility of organic synthesis, allowing chemists to create variations that might enhance biological activity or reduce side effects.
  • Medicinal Use: Some analogs of steroids are employed in medicine to treat conditions such as inflammation, autoimmune diseases, and hormonal deficiencies.
  • Chirality: The specific stereochemistry of this compound (indicated by the S configuration) is crucial, as even slight changes in the 3D arrangement of atoms can dramatically affect biological interactions.

As researchers continue to investigate these compounds, a deeper understanding of their mechanisms can lead to novel therapeutic agents. The structure-function relationship in such steroids is a vibrant area of study, highlighting why they are celebrated in both natural product chemistry and pharmacology.

In the words of a renowned chemist, “Understanding the architecture of molecules opens the door to new realms of biological discovery.” This emphasizes not just the complexity of compounds like (9S,14S,17S)-17-ethyl-13-methyl-2,3,4,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol, but also their immense potential!