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Colchicine

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Identification
Molecular formula
C22H25NO6
CAS number
64-86-8
IUPAC name
acetyl-[(7S)-1-hydroxy-2,3,10-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]ammonium;acetate
State
State

At room temperature, colchicine exists as a solid. It is highly stable in this state, providing a reliable form for both storage and usage in various applications.

Melting point (Celsius)
157.00
Melting point (Kelvin)
430.15
Boiling point (Celsius)
436.00
Boiling point (Kelvin)
709.15
General information
Molecular weight
399.44g/mol
Molar mass
399.4360g/mol
Density
1.6609g/cm3
Appearence

Colchicine is typically encountered as a yellowish crystalline powder. It is soluble in water, with a melting point that ensures it remains stable as a solid up to elevated temperatures under standard conditions.

Comment on solubility

Solubility of Acetyl-[(7S)-1-hydroxy-2,3,10-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]ammonium Acetate

The solubility characteristics of acetyl-[(7S)-1-hydroxy-2,3,10-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]ammonium acetate are influenced by various factors associated with its structure.

  • Polarity: The presence of multiple methoxy (-OCH3) groups enhances solubility in polar solvents due to the ability to form hydrogen bonds.
  • Ammonium Group: The ammonium moiety indicates that this compound could be soluble in water, as ammonium compounds typically exhibit enhanced solubility in aqueous solutions.
  • Acetate Ion: The acetate part may confer additional solubility in organic solvents due to its weakly polar nature, allowing for better interactions with non-polar solvents.

Overall, while the compound is likely soluble in a variety of solvents, its solubility can vary significantly based on factors such as:

  1. Temperature
  2. pH of the solution
  3. Presence of other solutes

In conclusion, acetyl-[(7S)-1-hydroxy-2,3,10-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]ammonium acetate may be expected to exhibit moderate to good solubility across a range of solvents, but empirical testing is recommended to determine precise solubility limits.

Interesting facts

Interesting Facts About Acetyl-[(7S)-1-hydroxy-2,3,10-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]ammonium; Acetate

The compound acetyl-[(7S)-1-hydroxy-2,3,10-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]ammonium, also known as a complex alkaloid derivative, is notable for its potential pharmacological properties. Here are some intriguing aspects of this compound:

  • Natural Product Origin: This compound is derived from plant sources, which are often rich in various bioactive molecules. It highlights the importance of nature in inspiring drug design and discovery.
  • Therapeutic Potential: Research suggests that compounds with similar structures may exhibit a range of biological activities, including anti-inflammatory, anti-cancer, and neuroprotective effects.
  • Complex Structure: The intricate arrangement of methoxy groups and the presence of a benzo[a]heptalen core make this compound a fascinating subject for structural chemistry.
  • Synergistic Effects: The various functional groups can potentially engage in synergistic interactions, enhancing the biological efficacy of the compound in medicinal chemistry.
  • Stereochemistry: The (7S) configuration indicates that the compound’s stereochemistry plays a crucial role in its biological activity. This highlights the importance of chirality in drug interactions and efficacy.

As a point of interest, researchers are continuously exploring how such compounds can be synthesized and manipulated for pharmaceutical applications, leading to novel treatments and therapies. The study of complex organic compounds like this one serves as a reminder of the intricate interplay between chemistry and biology.