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Amantadine hydrochloride

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Identification
Molecular formula
C10H18ClN
CAS number
665-66-7
IUPAC name
adamantan-2-amine;hydrochloride
State
State

At room temperature, amantadine hydrochloride exists as a solid.

Melting point (Celsius)
150.00
Melting point (Kelvin)
423.00
Boiling point (Celsius)
250.00
Boiling point (Kelvin)
523.00
General information
Molecular weight
187.71g/mol
Molar mass
187.7130g/mol
Density
1.0228g/cm3
Appearence

Amantadine hydrochloride appears as a white or almost white crystalline powder. It is highly soluble in water.

Comment on solubility

Solubility of Adamantan-2-amine Hydrochloride

The solubility of adamantan-2-amine hydrochloride is an intriguing feature of this compound, especially for its applications in various chemical and pharmaceutical fields. This compound exhibits solubility behavior that can be summarized as follows:

  • Water Solubility: Adamantan-2-amine hydrochloride is known to be soluble in water. This characteristic is crucial for its use in biological systems and drug formulations.
  • Organic Solvents: The solubility in organic solvents may vary, with moderate solubility expected in polar organic solvents.
  • Temperature Dependency: Solubility may increase with temperature, which is common for many solid compounds and can be essential for certain applications.

As a general observation, the presence of the +1 charge from the hydrochloride group enhances the compound's hydrophilicity, aiding in its solubility in aqueous environments. This property is significant for enhancing bioavailability and ensuring effective transport in physiological conditions.

In summary, adamantan-2-amine hydrochloride is seen as:

  1. Highly soluble in water.
  2. Potentially less soluble in non-polar organic solvents.
  3. Exhibiting temperature-dependent solubility changes.

Understanding these solubility characteristics is vital for the development and application of this compound in various scientific and industrial realms.

Interesting facts

Interesting Facts about Adamantan-2-amine Hydrochloride

Adamantan-2-amine hydrochloride is a fascinating compound that belongs to the class of amines, specifically derived from adamantane. This unique chemical structure imparts a range of interesting properties and applications:

  • Unique Structure: The backbone of adamantan-2-amine comprises a three-dimensional cage-like structure known as adamantane, which contributes to its distinctive chemical behavior.
  • Pharmaceutical Relevance: Like many amino-derivatives, this compound can be explored for potential pharmaceutical applications, especially in developing treatments for various neurological conditions.
  • Research Applications: Adamantan-2-amine has been studied in various fields, particularly in medicinal chemistry, where modifications of the adamantane structure can lead to novel compounds with enhanced biological activities.
  • Solubility Factor: As a hydrochloride salt, it often exhibits improved solubility compared to its base form, which can be advantageous in drug formulation.
  • Stability: The adamantane core is known for its stability, which is a significant factor when considering its potential as a precursor in the synthesis of other compounds.
  • Synthetic Pathways: Synthesis of adamantan-2-amine can involve reactions such as amination processes, allowing for diverse avenues of exploration in synthetic organic chemistry.

In the words of renowned chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas." This sentiment illustrates the value of compounds like adamantan-2-amine hydrochloride; their unique properties may lead to groundbreaking discoveries in various scientific domains.

Overall, the multifaceted nature of adamantan-2-amine hydrochloride makes it an enticing subject for further research, playing a role in the ongoing pursuit of scientific discovery and innovation.

Synonyms
10523-68-9
2-ADAMANTANAMINE, HYDROCHLORIDE
EINECS 234-074-2
Tricyclo(3.3.1.1(sup 3,7))decan-2-amine, hydrochloride
DTXSID60147021
DTXCID3069512
Tricyclo(3.3.1.1(sup 3,7))decan-2-amine, hydrochloride (9CI)
adamantan-2-amine hydrochloride
2-Adamantanamine hydrochloride
2-Aminoadamantane hydrochloride
2-Adamantylamine hydrochloride
2-Adamantanamine HCl
adamantan-2-amine;hydrochloride
MFCD00074743
Adamantan-2-ylamine hydrochloride
2-Adamantanamine, HCl
F1928-0024
2-Adamantaneammonium Chloride; 2-Adamantylamine Hydrochloride; 2-Aminoadamantane Hydrochloride
Tricyclo[3.3.1.13,7]decan-2-amine, hydrochloride
2-adamantylamine.HCl
2-adamantan amine HCl
Adamantan-2-amine HCl
2-amino-adamantane HCl
Adamantan-2-Ylamine HCl
2-aminoadamantane HCl salt
2aminoadamantane hydrochloride
2-admantaneamine hydrochloride
adamantan-2-aminehydrochloride
Tricyclo(3.3.1.13.7)dec-2-ylamine hydrochloride
SCHEMBL182372
2-adamantaneamine hydrochloride
adamantane-2-ylamine, chloride
2-adamantyl amine hydrochloride
CHEMBL447911
2-Adamantylamine hydrochloride, 99%
AKOS000104803
AKOS008965723
AKOS017343998
AC-1731
CS-W008112
FS-4489
PS-8449
SY011241
DB-003029
A0718
ST50825276
EN300-12539
F15457
tricyclo[3.3.1.13,7 ]decan-2-amine hydrochloride
Z90667176