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Mebendazole

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Identification
Molecular formula
C16H13N3O3
CAS number
31431-39-7
IUPAC name
[amino-[2-(2-hydroxy-5-methoxy-phenyl)-3H-benzimidazol-5-yl]methylene]ammonium
State
State

At room temperature, mebendazole is typically found in a crystalline solid state. It is not freely soluble in water, which influences its formulation for pharmaceutical use.

Melting point (Celsius)
290.00
Melting point (Kelvin)
563.15
Boiling point (Celsius)
360.00
Boiling point (Kelvin)
633.15
General information
Molecular weight
295.32g/mol
Molar mass
295.3200g/mol
Density
1.4360g/cm3
Appearence

Mebendazole appears as a white to slightly yellow powder. It is tasteless, or it may have a very slight characteristic odor. In commercial preparations, it is often available in a granular or crystalline form.

Comment on solubility

Solubility of Amino-[2-(2-Hydroxy-5-methoxy-phenyl)-3H-benzimidazol-5-yl]methyleneammonium (C16H13N3O3)

The solubility of amino-[2-(2-hydroxy-5-methoxy-phenyl)-3H-benzimidazol-5-yl]methyleneammonium can be described as follows:

  • Polar Characteristics: The presence of multiple hydroxyl (-OH) groups in the structure suggests higher polarity, which typically correlates with increased solubility in polar solvents, such as water.
  • Hydrophobic Influence: The methoxy group (-OCH3) and the benzimidazole backbone contribute hydrophobic characteristics; this may limit solubility in highly polar solvents.
  • Solvent Variability: Solubility can also be affected by the choice of solvent. For example, this compound may exhibit varying degrees of solubility in different organic solvents compared to aqueous solutions.
  • Temperature Dependence: As with many organic compounds, solubility may increase with temperature; this could be relevant in applications requiring dissolution of the compound.

In summary, while the amino-[2-(2-hydroxy-5-methoxy-phenyl)-3H-benzimidazol-5-yl]methyleneammonium compound may exhibit a degree of solubility in polar solvents, the overall solubility profile will depend on several factors including temperature, solvent type, and the structural balance between polar and hydrophobic regions. As a general rule, understanding the solubility dynamics of this compound is crucial for its practical applications in various fields.

Interesting facts

Interesting Facts about Amino-[2-(2-Hydroxy-5-methoxy-phenyl)-3H-benzimidazol-5-yl]methyleneammonium

Amino-[2-(2-hydroxy-5-methoxy-phenyl)-3H-benzimidazol-5-yl]methyleneammonium is a fascinating compound that combines the structural features of benzimidazole with a unique functional group, contributing to its diverse applications. Here are some noteworthy points:

  • Complex Structure: The presence of both a benzimidazole ring and a methoxy group provides distinct electronic properties that can influence its reactivity and stability.
  • Pharmaceutical Potential: Compounds with similar structures are often explored in medicinal chemistry for their potential anti-cancer and anti-inflammatory activities, making this compound of interest for drug development.
  • Importance of Hydroxy Group: The hydroxy group enhances the compound’s ability to form hydrogen bonds, increasing its solubility in biological environments, which is a critical factor for pharmaceutical efficacy.
  • Research Applications: Scientists are investigating compounds with such intricate designs for their roles in biological systems, particularly in the study of enzyme inhibition and receptor binding.
  • Emphasis on Stability: Due to its structural characteristics, the compound may exhibit significant stability against heat and light, which is essential for practical applications.

As highlighted in the words of renowned chemist Linus Pauling, “The best way to have a good idea is to have a lot of ideas.” Exploring compounds like this opens up numerous pathways for research and innovation.

In summary, amino-[2-(2-hydroxy-5-methoxy-phenyl)-3H-benzimidazol-5-yl]methyleneammonium represents a compelling intersection of chemical complexity and potential utility in the realm of medicinal chemistry and materials science.

Synonyms
2-(2-hydroxy-5-methoxy-phenyl)-1h-benzoimidazole-5-carboxamidine
{amino[2-(2-hydroxy-5-methoxyphenyl)-1H-1,3-benzodiazol-5-yl]methylidene}azanium
(amino(2-(2-hydroxy-5-methoxyphenyl)-1H-1,3-benzodiazol-5-yl)methylidene)azanium
BDBM13939
APC-6669
DB01905
PD008310
Q27093018
amino[2-(2-hydroxy-5-methoxyphenyl)-1H-benzimidazol-5-yl]methaniminium