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Hexamethylenimine

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Identification
Molecular formula
C6H13N
CAS number
111-49-9
IUPAC name
azepan-1-amine
State
State

At room temperature, hexamethylenimine is in a liquid state. It has the ability to form vapors and is soluble in a variety of solvents.

Melting point (Celsius)
-13.00
Melting point (Kelvin)
260.15
Boiling point (Celsius)
134.50
Boiling point (Kelvin)
407.70
General information
Molecular weight
99.19g/mol
Molar mass
99.1870g/mol
Density
0.8640g/cm3
Appearence

Hexamethylenimine is a colorless liquid with a fishy, amine-like odor. It appears as a clear fluid that can be easily vaporized due to its relatively low boiling point.

Comment on solubility

Solubility of Azepan-1-amine

Azepan-1-amine, also known as 1-Aminoazepane, displays interesting solubility characteristics due to its structural properties. When considering the solubility of azepan-1-amine, it’s essential to highlight several factors:

  • Polarity: The presence of the amine group (-NH2) increases the polarity of the compound, which generally enhances its solubility in polar solvents like water.
  • Hydrogen Bonding: Azepan-1-amine can participate in hydrogen bonding due to the amine group, further promoting its solubility in protic solvents.
  • Temperature Dependence: Like many organic compounds, the solubility of azepan-1-amine may increase with temperature, making it more soluble in warm solvents compared to cold ones.
  • Chain Length: The six-membered ring structure provides sufficient steric bulk, which can affect solubility depending on interacting solvents.

In summary, azepan-1-amine tends to be soluble in water and other polar solvents due to its polar functional group and ability to form hydrogen bonds. However, its solubility can vary with temperature and specific solvent conditions. Therefore, it's important to consider the context in which azepan-1-amine is used when evaluating its solubility properties.

Interesting facts

Interesting Facts about Azepan-1-amine

Azepan-1-amine, also known as 1-aminocycloheptane, is a fascinating cyclic amine that has garnered interest in both medicinal chemistry and organic synthesis. Its unique structure features a seven-membered ring, which contributes to its intriguing properties and applications. Here are some key points that highlight the significance of this compound:

  • Structural Characteristics: Azepan-1-amine contains a primary amine group and a saturated ring structure, giving it the potential for various chemical reactions, particularly in functionalization and substitution processes.
  • Biological Relevance: Compounds similar to azepan-1-amine often exhibit biological activities, making them valuable in the development of pharmaceuticals. The primary amine functional group can serve as a vital pharmacophore in drug design.
  • Synthesis Pathways: This compound can be synthesized through several routes, including cyclization reactions and reductions of ketones or amino acids, showcasing the versatility of synthetic methodologies in producing cyclic amines.
  • Potential Applications: Azepan-1-amine may play a role in the synthesis of more complex molecules used in research and industries, including agrochemicals and polymers. Its ability to act as a building block could lead to innovations in material science.
  • Research Insights: Ongoing research into azepan-1-amine's derivatives aims to uncover new compounds that provide enhanced therapeutic effects or reduced side effects, illustrating the compound's relevance in advancing medicinal chemistry.

As a chemistry student or enthusiast, exploring the mechanisms and applications of azepan-1-amine opens doors to understanding the intricacies of organic compounds and their roles in various scientific fields. Whether discussing its synthesis or its potential biological impacts, azepan-1-amine stands out as a compound worthy of closer examination.

Synonyms
1-Aminohomopiperidine
5906-35-4
1H-Azepin-1-amine, hexahydro-
1,1-Hexamethylenehydrazine
1-Aminohexamethyleneimine
EINECS 227-609-6
P6ST24BC3C
BRN 0471186
AI3-52440
NSC-82329
N-AMINOPERHYDROAZEPINE
N-AMINOHEXAHYDROAZEPINE
DTXSID2073358
5-20-04-00059 (Beilstein Handbook Reference)
NAminohomopiperidine
1Aminohomopiperidine
1Aminoperhydroazepine
1Aminohexahydroazepine
Perhydroazepin1ylamine
NAminohexamethylenimine
NAminohexamethyleneimine
1Aminohexamethyleneimine
Hexahydro1Hazepin1amine
1Aminohexahydro1Hazepine
1HAzepin1amine, hexahydro
1HAzepine, 1aminohexahydro
1HAzepine, hexahydro1amino
DTXCID6042529
1HAzepin1amine, hexahydro (9CI)
1HAzepine, 1aminohexahydro (8CI)
1H-Azepin-1-amine, hexahydro-(9CI)
227-609-6
ugbkournnqrepe-uhfffaoysa-n
un1993
azepan-1-amine
N-Aminohomopiperidine
N-Aminohexamethylenimine
N-Aminohexamethyleneimine
1-Aminoperhydroazepine
1-Aminohexahydroazepine
Aminohexamethyleneimine
1-Aminohexahydro-1H-azepine
1-Aminoazepane
Hexahydro-1H-azepin-1-amine
1H-Azepine, 1-aminohexahydro-
NSC 82329
N-Aminoazacycloheptane
(Azepan-1-yl)amine
1H-AZEPINE, HEXAHYDRO-1-AMINO-
Perhydroazepin-1-ylamine
azepan-1-ylamine
1-Azepanamine #
NSC82329
MFCD00003260
N-amino-homopiperidine
N-amino-hexahydroazepine
UNII-P6ST24BC3C
1-aminohexahydro(1h)azepine
SCHEMBL87653
1-Aminohomopiperidine, 95%
hexahydro-1-H-azepin-1-amine
AKOS003582851
AS-81223
DB-053313
A1084
CS-0204673
NS00034073
D88374
Q63395215