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Benzofuran-2-carboxylic acid

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Identification
Molecular formula
C9H6O3
CAS number
6872-68-8
IUPAC name
benzofuran-2-carboxylic acid
State
State
Benzofuran-2-carboxylic acid is a solid at room temperature, typically found in a crystalline powder form.
Melting point (Celsius)
176.00
Melting point (Kelvin)
449.15
Boiling point (Celsius)
336.00
Boiling point (Kelvin)
609.15
General information
Molecular weight
162.15g/mol
Molar mass
162.1490g/mol
Density
1.4397g/cm3
Appearence

Benzofuran-2-carboxylic acid appears as a white to light brown solid. It is typically crystalline in nature and may come in the form of powder or needle-shaped crystals.

Comment on solubility

Solubility of Benzofuran-2-carboxylic Acid

Benzofuran-2-carboxylic acid, with the chemical formula C9H6O3, exhibits intriguing solubility characteristics that are influenced by its molecular structure. Here are some key points regarding its solubility:

  • Solvent Variability: This compound is generally soluble in polar solvents such as water and alcohols due to its carboxylic acid functional group, which can form hydrogen bonds.
  • Temperature Dependence: Its solubility tends to increase with temperature; therefore, heating the solvent may enhance the dissolution rate.
  • pH Influence: As a carboxylic acid, benzofuran-2-carboxylic acid's solubility may increase in basic conditions due to deprotonation, leading to the formation of more soluble anionic species.
  • Application Insight: The solubility profile plays an essential role in the compound's application in pharmaceuticals and materials science, where solubility can affect bioavailability and reaction kinetics.

In summary, the solubility of benzofuran-2-carboxylic acid is multifaceted, dictated by factors such as solvent polarity, temperature, and pH levels. Understanding these aspects is crucial for leveraging this compound in various scientific applications.

Interesting facts

Interesting Facts about Benzofuran-2-carboxylic Acid

Benzofuran-2-carboxylic acid is a fascinating compound with various intriguing properties and applications that make it a significant subject of study in chemistry. Here are some noteworthy aspects:

  • Chemical Structure: This compound features a benzofuran moiety, which is a fused structure combining a benzene ring with a furan ring. This unique arrangement contributes to its chemical reactivity and functionality.
  • Biological Activity: Benzofuran-2-carboxylic acid is noted for its potential biological activities. Studies have indicated that derivatives of this compound exhibit antimicrobial, anti-inflammatory, and even anticancer properties, making it valuable in pharmaceutical research.
  • Applications in Chemistry: This compound serves as a vital intermediate in the synthesis of other complex organic molecules. Its carboxylic acid functional group allows for various chemical modifications, facilitating the creation of diverse chemical entities.
  • Synthesis: The synthesis of benzofuran-2-carboxylic acid often involves the cyclization of o-alkenyl phenols. Understanding its synthesis helps researchers design and develop new compounds with specific functionalities.
  • Functional Group Transformations: The presence of the carboxylic acid group allows for further transformations, such as esterification and amide formation. These transformations expand the range of applications for the compound and its derivatives.

Overall, benzofuran-2-carboxylic acid is more than just a chemical compound; it encapsulates a realm of potential that bridges organic chemistry with medicinal and synthetic applications. As further research unfolds, this compound may unlock new avenues in therapeutic development and material science.

Synonyms
Benzofuran-2-carboxylic acid
Coumarilic acid
2-BENZOFURANCARBOXYLIC ACID
NSC 6165
EINECS 207-818-9
UNII-7Z6NMG947L
BRN 0124204
7Z6NMG947L
AI3-03711
NSC-6165
COUMARILIC ACID [MI]
DTXSID2060090
5-18-06-00419 (Beilstein Handbook Reference)
DTXCID5040702
offspazvivzphu-uhfffaoysa-n
496-41-3
1-Benzofuran-2-carboxylic acid
Benzo[b]furan-2-carboxylic acid
Coumarone-2-carboxylic acid
2-Carboxybenzofuran
MFCD00005848
Benzo(b)furan-2-carboxylic acid
CHEMBL84095
NSC6165
benzofuran-2-carboxylicacid
4oyp
BZ2
Maybridge1_002455
2-benzofuranecarboxylic acid
Cambridge id 5102130
benzofuran 2-carboxylic acid
2-Benzofuran carboxylic acid
DivK1c_001207
SCHEMBL155789
1-benzofurane-2-carboxylic acid
HMS548H13
1-Benzofuran-2-carboxylic acid #
ALBB-016356
Benzofuran-2-carboxylic acid, 99%
BBL018112
BDBM50345230
STK293001
AKOS000103488
AB00533
CS-W004676
FB05783
SDCCGMLS-0065938.P001
SS-6002
CDS1_000167
NCGC00324555-01
SY005603
DB-022566
B1981
NS00031923
EN300-16967
O11693
AB01319519-02
Coumarilic acid; 1-Benzofuran-2-carboxylic acid
AN-278/25047013
Q27269061
Z56839706
F3096-1740