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Coumarin

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Identification
Molecular formula
C9H6O2
CAS number
91-64-5
IUPAC name
benzofuran-3-one
State
State

At room temperature, coumarin is typically in a solid state. It readily sublimes, transitioning from a solid to a gaseous state without passing through a liquid phase when exposed to air, contributing to its notable fragrance.

Melting point (Celsius)
68.00
Melting point (Kelvin)
341.00
Boiling point (Celsius)
301.00
Boiling point (Kelvin)
574.00
General information
Molecular weight
146.15g/mol
Molar mass
146.1480g/mol
Density
0.9350g/cm3
Appearence

Coumarin is a white crystalline solid with a sweet, vanilla-like odor, often described as reminiscent of freshly mown hay. It is used in the manufacture of perfumes and flavorings, lending a pleasant aroma to these products.

Comment on solubility

Solubility of Benzofuran-3-one

Benzofuran-3-one, a member of the benzofuran family, presents interesting solubility characteristics. It is known to be a relatively nonpolar organic compound, which impacts its behavior in various solvents. Here are some key points regarding its solubility:

  • Solvent Compatibility: Benzofuran-3-one is generally soluble in organic solvents such as alcohols, ethers, and hydrocarbons. However, its solubility in water is quite limited due to its hydrophobic nature.
  • Temperature Effects: Like many organic compounds, the solubility of benzofuran-3-one can increase with temperature. Higher temperatures often enhance the solubility of nonpolar and slightly polar compounds in organic solvents.
  • Applications: The solubility properties of benzofuran-3-one are significant in pharmaceutical and chemical syntheses, where it may act as an intermediate or a solvent.

Overall, understanding the solubility of benzofuran-3-one is crucial for its utilization in various chemical processes. As a generalization, one can confidently say that while it shows limited aqueous solubility, it remains compatible with a range of organic solvents, making it a versatile compound in many applications.

Interesting facts

Interesting Facts about Benzofuran-3-one

Benzofuran-3-one, an intriguing compound belonging to the class of benzofurans, has captured the attention of scientists due to its unique structure and versatile applications. Here are some fascinating aspects of this compound:

  • Structural Uniqueness: The compound features a bicyclic structure that combines a benzene ring fused to a furan ring. This structural configuration not only imparts stability but also influences its chemical reactivity.
  • Natural Occurrence: Benzofuran-3-one is found in various natural sources, often as a metabolite. Such natural occurrences add to its appeal in the field of natural product chemistry:
    • Can be isolated from specific plant extracts
    • Associated with various biological activities
  • Biological Importance: Scientists have found that benzofuran-3-one exhibits a range of biological activities, including:
    • Antioxidant properties
    • Antimicrobial potential
    • Anticancer effects
  • Synthesis Approaches: The synthesis of benzofuran-3-one can be achieved through several methods, highlighting its synthetic versatility. Common approaches include:
    • Electrophilic aromatic substitution reactions
    • Condensation reactions
  • Applications in Research: Researchers are increasingly interested in benzofuran-3-one as a starting material for designing new pharmaceuticals, agrochemicals, and other bioactive compounds. Its presence in drug development makes it a significant compound in medicinal chemistry.

In summary, benzofuran-3-one is not just another chemical entity; its unique attributes, multidimensional applications, and natural occurrences make it a topic worth exploring in the field of chemistry. As one researcher aptly put it, "The blend of beauty and utility in chemical structure often leads to the most unexpected opportunities in science."

Synonyms
Benzofuran-3(2H)-one
7169-34-8
3(2H)-BENZOFURANONE
Coumaranone
1-Benzofuran-3(2H)-one
Benzofuran-3-one
1-benzofuran-3-one
2,3-dihydro-1-benzofuran-3-one
KZ7LS8K9LP
CCRIS 3596
NSC-512726
DTXSID20221917
NSC 512726
DTXCID50144408
640-279-1
3-Coumaranone
2H-BEZOFURAN-3-ONE
Coumaran-3-one
71699-34-8
2,3-Dihydrobenzo[b]furan-3-one
2H-BENZOFURAN-3-ONE
3-BENZOFURANONE
MFCD00051810
2H-3-Benzofuranone
BENZO[B]FURAN-3(2H)-ONE
benzofuran-3 (2h)-one
UNII-KZ7LS8K9LP
benzofuran-3-(2H)-one
3-(2H)-benzo[b]furanone
NCIOpen2_003700
SCHEMBL69412
1-benzofuran-3 (2H)-one
1-benzofuran-3-(2H)-one
3-(2H)-benzo[b]-furanone
1-Benzofuran-3(2H)-one #
CHEMBL2253270
BCP07835
STR06709
2,3-DIHYDROBENZOFURAN-3-ONE
NSC512726
AKOS000223931
AB02144
CCG-356035
CS-W001165
HY-W001165
PB43343
PS-4359
AC-20612
AC-30814
SY011530
DB-021593
C2825
Benzofuran-3(2H)-one, >=98.0% (HPLC)
EN300-49168
Z57101103