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Amlodipine

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Identification
Molecular formula
C20H25ClN2O5
CAS number
88150-42-9
IUPAC name
benzyl-[2-[5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carbonyl]oxyethyl]-methyl-ammonium
State
State
Amlodipine is in the form of a solid powder at room temperature. This state is stable under normal environmental conditions, making it suitable for long-term pharmaceutical storage and handling.
Melting point (Celsius)
178.00
Melting point (Kelvin)
451.15
Boiling point (Celsius)
643.50
Boiling point (Kelvin)
916.65
General information
Molecular weight
408.88g/mol
Molar mass
408.8790g/mol
Density
1.1850g/cm3
Appearence

Amlodipine typically appears as a white to off-white crystalline powder. It is not visibly distinct in terms of color, allowing it to be easily compounded with other excipients in pharmaceutical formulations. In its raw form, it may clump due to its fine powdery nature.

Comment on solubility

Solubility of Benzyl-[2-[5-Methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carbonyl]oxyethyl]-methyl-ammonium

The solubility of the compound benzyl-[2-[5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carbonyl]oxyethyl]-methyl-ammonium (C20H25ClN2O5) can be influenced by several factors:

  • Polarity: Due to the presence of multiple polar functional groups in its structure, such as carbonyls and an ammonium group, this compound may exhibit some level of solubility in polar solvents like water or alcohols.
  • Hydrophobic Regions: The presence of the bulky aromatic structures may lead to decreased solubility in polar solvents, hence this compound may show better solubility in organic solvents such as dichloromethane or ethyl acetate.
  • pH Dependence: The solubility may also vary significantly with pH due to the ionization of the ammonium group, affecting its overall solubility profile in aqueous solutions.
  • Concentration of Ionic Species: In solutions containing a variety of ionic compounds, the solubility can be altered owing to 'salting-in' or 'salting-out' effects.

As a general observation, it can be stated that while the functional groups may provide avenues for solubility in certain solvents, the overall structure suggests a complex behavior that must be characteristically assessed across different solvent systems before drawing definitive conclusions. Therefore, empirical studies are essential for a better understanding of its solubility profile.

Interesting facts

Interesting Facts about Benzyl-[2-[5-Methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carbonyl]oxyethyl]-methyl-ammonium

This compound, known for its complex structure and biological activity, is a derivative of dihydropyridine, a class of compounds that has garnered significant attention in medicinal chemistry.

Key Characteristics:

  • Pharmacological Potential: Compounds featuring the dihydropyridine skeleton are widely recognized for their cardiovascular properties, particularly as calcium-channel blockers. This may position this compound as a candidate for treating hypertension.
  • Functional Groups: The presence of multiple functional groups, including methoxycarbonyl and nitro groups, suggests diverse chemical reactivity and potential for further modification, making it a versatile core for medicinal applications.
  • Research Insights: Dihydropyridine derivatives have been the subject of various studies, with some research indicating their effectiveness in managing conditions like angina pectoris and arrhythmias.

Synthetic Applicability:

The intricate design of this compound allows for various synthetic pathways, enabling chemists to explore different methodologies while enhancing yields and purities. Additionally, derivatives can be created through selective modifications, potentially improving drug-like properties.

Quote from Research:

“Compounds that display dihydropyridine frameworks often exhibit a dual role as both therapeutic agents and essential intermediates in synthetic organic chemistry.”

In conclusion, benzyl-[2-[5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carbonyl]oxyethyl]-methyl-ammonium represents a noteworthy link between organic chemistry and pharmacology, highlighting the significance of structural diversity in the development of new therapeutic agents.

Synonyms
HMS1361F11