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Cyclophosphamide

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Identification
Molecular formula
C8H10Cl2O4
CAS number
111-48-8
IUPAC name
bis(2-chloroethyl) but-2-enedioate
State
State

At room temperature, bis(2-chloroethyl) but-2-enedioate is typically a liquid. It has low volatility and is relatively stable, although it may degrade over time or upon exposure to moisture.

Melting point (Celsius)
-62.60
Melting point (Kelvin)
210.50
Boiling point (Celsius)
249.00
Boiling point (Kelvin)
522.15
General information
Molecular weight
210.06g/mol
Molar mass
179.0430g/mol
Density
1.2580g/cm3
Appearence

Bis(2-chloroethyl) but-2-enedioate is a colorless, viscous liquid that can have a slightly sweet or chloroform-like odor. It is typically clear, but impurities can impart a yellowish hue. Due to its chlorine content, it may also possess a mild chlorine smell. The substance is soluble in organic solvents and may hydrolyze slowly in water.

Comment on solubility

Solubility of bis(2-chloroethyl) but-2-enedioate

bis(2-chloroethyl) but-2-enedioate is a compound which exhibits unique solubility characteristics that are worth noting. Understanding the solubility of this compound is paramount, especially in applications involving organic solvents and aqueous systems.

Solubility Characteristics:

  • Polar Compounds: The presence of the chloroethyl groups introduces polarity, which significantly affects the solubility behavior.
  • Solvent Compatibility: This compound is likely to be soluble in organic solvents such as ethyl acetate, chloroform, and dichloromethane.
  • Aqueous Solubility: It is expected to have low solubility in water, primarily due to the bulky hydrophobic characteristics of the but-2-enedioate moiety.

Thus, when considering solvent options, one should primarily use organic solvents to achieve effective dissolution of bis(2-chloroethyl) but-2-enedioate. Always remember that factors such as temperature and solvent polarity can greatly influence the solubility behavior of this compound. As with many organic compounds, the general rule of thumb is that “like dissolves like,” emphasizing the importance of choosing appropriate solvents for dissolution.

Interesting facts

Interesting Facts about Bis(2-chloroethyl) But-2-enedioate

Bis(2-chloroethyl) but-2-enedioate is a fascinating compound with a variety of applications in both organic chemistry and industrial processes. Here are some notable aspects:

  • Structure and Reactivity: This compound contains a double bond and two chlorine substituents, which contribute to its unique reactivity. The presence of the but-2-enedioate moiety makes it an interesting target for further chemical transformations.
  • Applications: It is widely used in the production of polymers and can serve as a reagent in organic synthesis. Researchers often explore its potential as a building block for more complex molecules.
  • Toxicity Concerns: Given its structure, bis(2-chloroethyl) but-2-enedioate may pose health risks. Chlorinated compounds are typically associated with carcinogenic properties, making safety measures essential when handling this compound.
  • Historical Significance: The use of chlorinated compounds in chemical warfare during World War I led to increased interest in studies concerning their reactivity and toxicology, including compounds like bis(2-chloroethyl) but-2-enedioate.
  • Research Potential: Ongoing research continues to investigate derivatives of bis(2-chloroethyl) but-2-enedioate, aiming to unlock new applications in medicinal chemistry, such as targeted drug delivery systems.

In summary, bis(2-chloroethyl) but-2-enedioate is not just a compound of interest for its synthetic utility; it also carries a rich history and potential for future research. As scientists endeavor to understand and harness its properties, this compound stands at the crossroads of chemistry, health, and innovation.