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Nitrogen mustard hydrochloride

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Identification
Molecular formula
C12H18Cl3N
CAS number
552-36-7
IUPAC name
bis(2-chloroethyl)-(p-tolylmethyl)ammonium;chloride
State
State

This compound is generally found as a crystalline solid at room temperature.

Melting point (Celsius)
382.00
Melting point (Kelvin)
655.15
Boiling point (Celsius)
435.00
Boiling point (Kelvin)
708.15
General information
Molecular weight
242.64g/mol
Molar mass
242.1620g/mol
Density
1.3350g/cm3
Appearence

Bis(2-chloroethyl)-(p-tolylmethyl)ammonium chloride typically appears as a white to off-white crystalline solid.

Comment on solubility

Solubility of bis(2-chloroethyl)-(p-tolylmethyl)ammonium;chloride

When examining the solubility of bis(2-chloroethyl)-(p-tolylmethyl)ammonium;chloride, it is important to consider several key factors:

  • Polarity: This compound is likely polar due to the presence of the quaternary ammonium group and chlorine ions, which typically increases its solubility in polar solvents like water.
  • Ionic Character: Being a salt (as indicated by the chloride ion), it may dissolve readily in aqueous solutions, making it more soluble in water compared to organic solvents.
  • Temperature Effects: Higher temperatures generally promote solubility for ionic compounds, so increasing the temperature could enhance the dissolution of this compound.
  • Common Solvents: It may show some degree of solubility in common polar organic solvents like methanol and ethanol but may be less soluble in non-polar solvents due to the ionic nature of the compound.

In summary, the solubility of bis(2-chloroethyl)-(p-tolylmethyl)ammonium;chloride can be characterized as follows:

  • Highly soluble in water due to its ionic character.
  • Moderate solubility in polar organic solvents.
  • Low solubility in non-polar solvents.

As you explore its solubility, remember that factors such as the solvent type, temperature, and the ionic versus molecular nature of the compound play crucial roles in determining how well it will dissolve.

Interesting facts

Interesting Facts about Bis(2-chloroethyl)-(p-tolylmethyl)ammonium Chloride

Bis(2-chloroethyl)-(p-tolylmethyl)ammonium chloride, often referred to as a quaternary ammonium compound, has gained attention for its multifaceted applications in various fields of chemistry and medicine. Here are some intriguing aspects of this compound:

  • Quaternary Structure: As a quaternary ammonium compound, it has four organic groups attached to a nitrogen atom, which imparts unique properties related to its reactivity and solubility.
  • Antimicrobial Properties: Compounds like bis(2-chloroethyl)-(p-tolylmethyl)ammonium chloride are often studied for their ability to inhibit microbial growth, making them valuable in disinfectants and antiseptic formulations.
  • Precursor for Drug Development: This compound is integral to the synthesis of various pharmaceuticals, particularly in developing drugs with targeted activity against certain biological targets.
  • Reaction Mechanism Insights: The presence of chloroethyl groups can provide insight into its reaction mechanisms, particularly in nucleophilic substitution reactions, which are foundational to organic chemistry.
  • Applications in Agriculture: Research has indicated potential uses in agricultural settings, particularly as herbicides or fungicides due to its toxicological profile against certain pests.

As you delve into the study of this compound, remember that its unique structural characteristics not only define its chemical behavior but also open doors to innovative solutions in medicinal chemistry and beyond. To quote a famous chemist, “Chemistry is the soul of science; everything else is merely details.”
With compounds like bis(2-chloroethyl)-(p-tolylmethyl)ammonium chloride, the details can lead to groundbreaking discoveries!

Synonyms
3597-21-5
p-Methyl-di-(2-chloroethyl)-benzylamine hydrochloride
bis(2-chloroethyl)-[(4-methylphenyl)methyl]azanium;chloride
p-Embitol
NSC 67249
bis(2-chloroethyl)[(4-methylphenyl)methyl]amine hydrochloride
2-chloro-N-(2-chloroethyl)-N-(4-methylbenzyl)-1-ethanaminium chloride
Benzenemethanamine, N,N-bis(2-chloroethyl)-4-methyl-, hydrochloride
BENZYLAMINE, N,N-BIS(2-CHLOROETHYL)-p-METHYL-, HYDROCHLORIDE
AKOS005102566
8X-0952