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Chlormethine hydrochloride

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Identification
Molecular formula
C4H12Cl3N
CAS number
55-86-7
IUPAC name
bis(2-chloroethyl)ammonium;chloride
State
State

At room temperature, Chlormethine hydrochloride is in a solid state. It is stable under normal conditions, but should be handled with care as it can react with moisture and is used in sensitive applications such as chemotherapy.

Melting point (Celsius)
170.00
Melting point (Kelvin)
443.00
Boiling point (Celsius)
479.85
Boiling point (Kelvin)
753.00
General information
Molecular weight
156.58g/mol
Molar mass
156.5830g/mol
Density
1.7920g/cm3
Appearence

Chlormethine hydrochloride typically appears as a white or almost white crystalline powder. The substance is hygroscopic, meaning it can absorb moisture from the air, leading to potential clumping when exposed. It is commonly utilized in medical settings and research.

Comment on solubility

Solubility of bis(2-chloroethyl)ammonium chloride

The solubility of bis(2-chloroethyl)ammonium chloride in various solvents can be intriguing. This compound is known to demonstrate significant solubility characteristics, particularly in polar solvents. Here are some key points regarding its solubility:

  • Polar Solvents: bis(2-chloroethyl)ammonium chloride readily dissolves in water and other polar solvents due to its ionic nature. The ammonium cation and chloride anion interact favorably with polar molecules, promoting solvation.
  • Non-Polar Solvents: Conversely, its solubility in non-polar solvents is quite limited. This is primarily because the ionic interactions are not favored in such media, leading to poor solubility.
  • Temperature Influence: The solubility may also be influenced by temperature; generally, an increase in temperature enhances the solubility of ionic compounds in aqueous solutions.
  • Concentration Effects: It's noteworthy that the solubility can vary with concentration, as higher concentrations may lead to saturation, impacting further dissolution.

In summary, the solubility of bis(2-chloroethyl)ammonium chloride is optimal in polar solvents, which aligns with its ionic structure. This characteristic makes it useful for various applications where solubility in water is beneficial.

Interesting facts

Interesting Facts About Bis(2-Chloroethyl)ammonium Chloride

Bis(2-chloroethyl)ammonium chloride, often abbreviated as BCEA chloride, is a fascinating compound with a variety of applications and properties that intrigue scientists and chemists alike. Here are some captivating points about this compound:

  • Chemical Structure: This compound features a unique structure where two chlorinated ethyl groups are attached to a nitrogen atom. This design allows for interesting reactivity and interaction with other substances.
  • Use in Research: BCEA chloride is notable for its role in biochemical research, particularly as an alkylating agent. It has been studied for its ability to modify molecules, which can influence various biochemical processes.
  • Potential in Therapeutics: Due to its alkylating properties, bis(2-chloroethyl)ammonium chloride is also being explored for potential uses in therapeutic applications, especially in cancer treatment. Alkylators can interfere with DNA replication in cancer cells, which may offer a pathway for treatment.
  • Formulation Considerations: When handling this compound, safety precautions are paramount. It is important to use proper safety gear and work in well-ventilated areas due to its chemical reactivity and potential toxicity.
  • Regulatory Status: As a compound with significant biological activity, its use is often regulated, making it crucial for researchers to be aware of the legal considerations regarding its handling and disposal.

In summary, bis(2-chloroethyl)ammonium chloride serves as a prime example of how a relatively simple compound can play a complex role in both research and potential therapeutic applications. Its structure, reactivity, and implications in science make it an essential topic of discussion among chemistry enthusiasts and professionals.

Synonyms
bis(2-chloroethyl)azanium;chloride
LEO 72a
NC 26
SK 555
TL 161
102092-04-6
DIETHYLAMINE, 2,2'-DICHLORO-, HYDROCHLORIDE
bis(2-chloroethyl)azanium chloride
beta,beta'-Dichlorodiethylamine hydrochloride
AKOS025117316