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Clotrimazole

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Identification
Molecular formula
C15H12Cl2NO
CAS number
23593-75-1
IUPAC name
bis(4-chlorophenyl)-(3-pyridyl)methanol
State
State

Solid. At room temperature, clotrimazole exists as a solid state, known for its stability and crystalline form.

Melting point (Celsius)
142.50
Melting point (Kelvin)
415.60
Boiling point (Celsius)
625.00
Boiling point (Kelvin)
898.15
General information
Molecular weight
305.16g/mol
Molar mass
305.1610g/mol
Density
1.2790g/cm3
Appearence

White crystalline solid. The compound typically exhibits a fine crystalline structure that is often odorless.

Comment on solubility

Solubility of bis(4-chlorophenyl)-(3-pyridyl)methanol

bis(4-chlorophenyl)-(3-pyridyl)methanol exhibits intriguing solubility characteristics that can be attributed to its polar structure. The compound features both aromatic chlorinated groups and a pyridine ring, which can engage in hydrogen bonding and dipole-dipole interactions.

Key points regarding its solubility include:

  • Polar vs. Non-Polar Solvents: bis(4-chlorophenyl)-(3-pyridyl)methanol is likely to be soluble in polar solvents such as water and methanol due to its hydroxyl group, which can form hydrogen bonds.
  • Organic Solvents: It may also be soluble in a range of organic solvents, including ethanol and dimethyl sulfoxide (DMSO), which can accommodate its aromatic and polar characteristics.
  • Limited Solubility: The presence of the chlorophenyl groups may limit solubility in highly non-polar solvents like hexane, as the non-polar regions do not favor mixing.

In practical applications, understanding the solubility of bis(4-chlorophenyl)-(3-pyridyl)methanol aids in formulating effective solutions for various chemical processes. The compound’s solubility profile highlights the balance between its polar and non-polar characteristics, making it a fascinating subject of study in terms of how molecular structure influences solubility.

Interesting facts

Interesting Facts about Bis(4-Chlorophenyl)-(3-Pyridyl)methanol

Bis(4-chlorophenyl)-(3-pyridyl)methanol is a fascinating compound with unique structural characteristics and potential applications in various fields. Here are some interesting insights about this compound:

  • Molecular Structure: The compound features a central carbon atom bonded to two 4-chlorophenyl groups and one 3-pyridyl group, creating a complex, multi-ring framework that enhances its chemical reactivity.
  • Applications in Medicine: Research suggests that compounds similar to bis(4-chlorophenyl)-(3-pyridyl)methanol may exhibit biological activity, making them potential candidates for pharmaceutical development.
  • Pesticide Use: The chlorinated phenyl groups are a hallmark of numerous agrochemicals, hinting at possible use in pest control due to their bioactivity.
  • Research Interest: This compound, due to its distinctive functional groups, is of particular interest in organic chemistry for studying reaction mechanisms and synthesis pathways.
  • Structure-Activity Relationship (SAR): Understanding how variations in the molecule's structure affect its activity is an ongoing area of research, particularly for medicinal chemists.

As noted by many researchers, "the journey of exploration into complex compounds often leads to unexpected discoveries." Bis(4-chlorophenyl)-(3-pyridyl)methanol certainly exemplifies this sentiment, as it opens doors to innovation in chemical synthesis and application.

With its intricate structure and potential for diverse applications, this compound remains an exciting topic for investigation in the world of chemistry.

Synonyms
Parinol
17781-31-6
Parnon
Bis(4-chlorophenyl)-3-pyridylmethanol
3-Pyridinemethanol, alpha,alpha-bis(4-chlorophenyl)-
EL 241
alpha,alpha-Bis(4-chlorophenyl)pyridine-3-methanol
bis(4-chlorophenyl)-pyridin-3-ylmethanol
Bis-(4-chloro-phenyl)-pyridin-3-yl-methanol
CHEMBL135115
DTXSID4042256
V8D29I1K71
ALPHA,ALPHA-BIS-(4-CHLOROPHENYL)PYRIDINE-3-METHANOL
bis-(4-chlorophenyl)pyridin-3-yl-methanol
Parinol [ANSI]
.alpha.,.alpha.-Bis(4-chlorophenyl)-3-pyridinemethanol
Caswell No. 637A
EINECS 241-761-0
EPA Pesticide Chemical Code 046501
BRN 1540839
UNII-V8D29I1K71
alpha,alpha-Bis(4-chlorophenyl)-3-pyridinemethanol
alpha,alpha-Bis-(p-chlorophenyl)-3-pyridinemethanol
EL-241
alpha,alpha,alpha-Bis(P-chlorophenyl)-3-pyridinemethanol
bis(4-chlorophenyl)pyridin-3-yl-methanol
3-Pyridinemethanol, alpha,alpha-bis(p-chlorophenyl)-
alpha-alpha-Bis(p-chlorophenyl)-3-pyridine methanol
3-Pyridinemethanol, alpha,alpha-bis-(4-chlorophenyl)-
3-Pyridinemethanol, alpha,alpha-bis-(p-chlorophenyl)-
SCHEMBL7685830
DTXCID2022256
3-Pyridinemethanol, .alpha.,.alpha.-bis(4-chlorophenyl)-
3-Pyridinemethanol, .alpha.,.alpha.-bis(p-chlorophenyl)-
NBNTWDUNCHRWMT-UHFFFAOYSA-N
DNDI1267127
SAA78131
Tox21_301259
BDBM50014758
AKOS024388262
NCGC00160465-01
NCGC00255933-01
Bis-(4-chlorophenyl)pyridin-3-ylmethanol
bis(4-chlorophenyl)-3-pyridylmethan-1-ol
CAS-17781-31-6
Bis(4-chlorophenyl)(3-pyridinyl)methanol #
NS00025863
ST51042257
Q27291667