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Nifuroxazide

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Identification
Molecular formula
C12H10N2O5
CAS number
965-52-6
IUPAC name
butyl 5-methyl-3-(5-nitro-2-furyl)isoxazole-4-carboxylate
State
State

Nifuroxazide is a solid at room temperature. It is typically provided in powder form for pharmaceutical use.

Melting point (Celsius)
151.00
Melting point (Kelvin)
424.15
Boiling point (Celsius)
420.00
Boiling point (Kelvin)
693.15
General information
Molecular weight
275.25g/mol
Molar mass
275.2450g/mol
Density
1.5300g/cm3
Appearence

Nifuroxazide is typically a yellow crystalline powder. It is observably bright in color, which makes it identifiable when in powdered form.

Comment on solubility

Solubility of Butyl 5-methyl-3-(5-nitro-2-furyl)isoxazole-4-carboxylate

The solubility of Butyl 5-methyl-3-(5-nitro-2-furyl)isoxazole-4-carboxylate can be quite nuanced, given its complex structure.

Factors Influencing Solubility:

  • Polarity: The presence of the isoxazole ring and nitro group significantly influences the compound's polarity, affecting its interactions with solvents.
  • Functional Groups: The carboxylate group can enhance solubility in polar solvents, but the bulky butyl group may hinder solubility in less polar environments.
  • Temperature: Solubility can increase with temperature, allowing for greater dissolution in various solvents under heated conditions.

In general, one could posit that:

  • In polar solvents (like water): Solubility may be limited due to the hydrophobic characteristics of the butyl chain.
  • In organic solvents (such as ethanol or acetone): It may demonstrate better solubility owing to compatible polar and non-polar interactions.

In summary, the compound's solubility is mainly dictated by its structural attributes and the nature of the solvent used. Careful consideration of these factors is essential for predicting its solubility profile.

Interesting facts

Interesting Facts about Butyl 5-Methyl-3-(5-Nitro-2-Furyl)Isoxazole-4-Carboxylate

Butyl 5-methyl-3-(5-nitro-2-furyl)isoxazole-4-carboxylate is a fascinating compound that falls into the category of isoxazole derivatives, which are known for their diverse biological activities. Here are some intriguing aspects of this compound:

  • Bioactivity: Compounds like butyl 5-methyl-3-(5-nitro-2-furyl)isoxazole-4-carboxylate have been studied for their potential pharmacological properties, including anti-inflammatory, analgesic, and antimicrobial effects.
  • Structural Significance: The isoxazole ring structure in this compound provides unique electronic properties and stability, making it an important scaffold in drug design.
  • Synthetic Approaches: The synthesis of this compound can involve various organic reactions, including cyclization and functional group transformations, showcasing the versatility of organic synthesis methods.
  • Research Applications: As a research compound, it can serve as a lead structure for developing new therapeutic agents by modifying its functional groups to enhance efficacy and reduce toxicity.
  • Environmental Considerations: Nitro groups (like the one present in this compound) can impact the compound's behavior in the environment, influencing aspects such as biodegradability and potential environmental toxicity.

In summary, the exploration of butyl 5-methyl-3-(5-nitro-2-furyl)isoxazole-4-carboxylate not only provides insight into its chemical properties but also highlights its potential significance in medicinal chemistry and drug development. As scientists delve into the study of such compounds, they often remind us that "the journey of discovery never truly ends," opening up avenues for future research and innovation.

Synonyms
4-ISOXAZOLECARBOXYLIC ACID, 5-METHYL-3-(5-NITRO-2-FURYL)-, BUTYL ESTER
22996-59-4
5-Methyl-3-(5-nitro-2-furyl)-4-isoxazolecarboxylic acid butyl ester
DTXSID20177541