Interesting facts
Interesting Facts About Chloroform
Chloroform, known scientifically as trichloromethane, is a fascinating compound with a rich history and diverse applications. Here are some intriguing aspects of chloroform:
- Historical significance: Chloroform was first discovered in 1831 by the French chemist Samuel Guthrie, and its anesthetic properties were later popularized by James Young Simpson. He famously used it in 1847 during childbirth, allowing many women to benefit from pain relief during labor.
- Dual nature: While chloroform's anesthetic properties made it a revolutionary compound in medicine, it has also been recognized for its potential health risks. Prolonged exposure can lead to respiratory and liver issues, making safety precautions essential in laboratories and medical settings.
- Solvent versatility: Chloroform is widely used as an organic solvent in laboratories. It dissolves a variety of organic compounds, making it invaluable for extraction and purification processes, particularly in organic chemistry.
- Environmental concerns: Due to its potential for harm, chloroform is regulated in many countries. It can be a byproduct of chlorination processes in water treatment, raising concerns about its presence in drinking water sources.
- Fun fact: Chloroform has a sweet and pleasant smell, which can make it deceptively appealing; however, its inhalation can lead to dizziness and nausea, underscoring the importance of handling it with caution.
In conclusion, chloroform is more than just a chemical compound; its journey through history highlights both the advancements in science and the necessary precautions we must take to ensure safety in its use.
Synonyms
CHLOROFORM
Trichloromethane
67-66-3
Trichlormethan
Formyl trichloride
Trichloroform
Methane, trichloro-
Methenyl trichloride
Chloroforme
Methyl trichloride
Methane trichloride
CHCl3
R 20 (Refrigerant)
Triclorometano
Cloroformio
Trichloormethaan
Freon 20
1,1,1-Trichloromethane
Methenyl chloride
RCRA waste number U044
NCI-C02686
Chloroformum
Caswell No. 192
Chloroform bp
Methylidyne trichloride
HSDB 56
Refrigerant R20
CCRIS 137
NSC 77361
trichloro-methane
Hcc 20
R 20
EINECS 200-663-8
NSC-77361
EPA Pesticide Chemical Code 020701
UNII-7V31YC746X
BRN 1731042
DTXSID1020306
CHEBI:35255
AI3-24207
7V31YC746X
Chloroform [UN1888] [Poison]
chloroformium pro narcosi
DTXCID10306
EC 200-663-8
4-01-00-00042 (Beilstein Handbook Reference)
NSC77361
MFCD00000826
NCGC00090794-01
chloroform CHCl3
CHLOROFORM (II)
CHLOROFORM [II]
CHLOROFORM (IARC)
CHLOROFORM [IARC]
CHLOROFORM (MART.)
CHLOROFORM [MART.]
CHLOROFORM (USP-RS)
CHLOROFORM [USP-RS]
Chloroform, analytical standard
Chloroforme [French]
Cloroformio [Italian]
Trichlormethan [Czech]
Chloroform [NF XVII]
Trichloormethaan [Dutch]
Triclorometano [Italian]
CAS-67-66-3
Chloroform [NF]
Chloroform (Stabilized with ~1% Ethanol)
CHLOROBUTANOL IMPURITY A (EP IMPURITY)
CHLOROBUTANOL IMPURITY A [EP IMPURITY]
CHLOROFORM, ACS
CHLOROFORMWith Amylene
CHLOROFORMWith Ethanol
UN1888
Chloroform (Anhydrous) Contains Amylenes as stabilizer
RCRA waste no. U044
chlorform
chloroforrn
cloroform
trichlormethane
chloro form
chloro-form
Chloroform-
Chloroform, for HPLC, >=99.8%, contains 0.5-1.0% ethanol as stabilizer
trichloro- methane
methane trichloride
tris(chloranyl)methane
CCl3H
HCCl3
Chloroform, for HPLC
Trichloromethane, 9CI
CHLOROFORM [MI]
Chloroform, ethanol-free
Chloroform, HPLC Grade
Trichlormethan/Chloroform
WLN: GYGG
CHLOROFORM [HSDB]
CHLOROFORM [VANDF]
CHLOROFORMUM [HPUS]
R 20(REFRIGERANT)
CHLOROFORM [WHO-DD]
Pesticide Code: 020701
CHEMBL44618
Chloroform, p.a., 99.8%
GTPL2503
NCI-CO2686
CHLOROFORM [GREEN BOOK]
DTXSID10953654
R 20 (VAN)
Chloroform with Amylene HPLC grade
Chloroform, Spectrophotometric Grade
Chloroform (stabilized with ethanol)
Tox21_111024
Tox21_202494
Chloroform, for HPLC, >=99.5%
Chloroform, for HPLC, >=99.8%
AKOS000269026
Chloroform 100 microg/mL in Methanol
DB11387
InChI=1/CHCl3/c2-1(3)4/h1
UN 1888
Chloroform 5000 microg/mL in Methanol
Chloroform, purification grade, >=99%
NCGC00090794-02
NCGC00260043-01
F 20
R-20
Trichloromethane 10 microg/mL in Methanol
Chloroform, JIS special grade, >=99.0%
Trichloromethane 100 microg/mL in Methanol
C0819
NS00007346
Trichloromethane 5000 microg/mL in Methanol
Chloroform, HPLC grade stabilized with ethanol
Chloroform (stabilized with 2-Methyl-2-butene)
Chloroform, SAJ super special grade, >=99.0%
A835850
L023971
Q172275
BRD-K88785477-001-01-8
Chloroform, for HPLC, >=99.8%, amylene stabilized
Chloroform, 99.8%, ACS Reagent stabilized with Ethanol
Chloroform, technical, amylene stabilized, >=99% (GC)
F0001-1775
Chloroform, technical grade, 95%, contains 50 ppm Amylene
Chloroform, anhydrous, contains amylenes as stabilizer, >=99%
Chloroform, for HPLC, >=99.8% (chloroform + ethanol, GC)
Chloroform stabilized with 50-200 ppm Amylene ACS Reagent Grade
Chloroform, >=99%, PCR Reagent, contains amylenes as stabilizer
Chloroform, ACS reagent, >=99.8%, contains amylenes as stabilizer
Chloroform, AR, contains 1-2% ethanol as stabilizer, >=99.5%
Chloroform, AR, contains 100 ppm amylene as stabilizer, >=99.5%
Chloroform, contains 100-200 ppm amylenes as stabilizer, >=99.5%
Chloroform, contains amylenes as stabilizer, ACS reagent, >=99.8%
Chloroform, contains ethanol as stabilizer, ACS reagent, >=99.8%
Chloroform, LR, contains 100 ppm amylene as stabilizer, >=99%
Chloroform, p.a., ACS reagent, 99.8%, contains 0.005% Amylene
Chloroform, SAJ first grade, >=99.0%, contains 0.4-0.8% ethanol
Chloroform, UV HPLC spectroscopic, 99.9%, contains 50 ppm Amylene
Chloroform, ACS reagent, Reag. Ph. Eur., contains ethanol as stabilizer
Chloroform, anhydrous, >=99%, contains 0.5-1.0% ethanol as stabilizer
Chloroform, Pharmaceutical Secondary Standard; Certified Reference Material
Chloroform, puriss. p.a., reag. ISO, reag. Ph. Eur., 99.0-99.4% (GC)
Chloroform, UV HPLC spectroscopic, 99.0%, contains 0.6-1.0% Ethanol
Chloroform, ACS reagent, >=99.8%, contains 0.5-1.0% ethanol as stabilizer
Chloroform, ACS spectrophotometric grade, >=99.8%, contains amylenes as stabilizer
Chloroform, biotech. grade, >=99.8%, contains 0.5-1.0% ethanol as stabilizer
Chloroform, p.a., ACS reagent, reag. ISO, 99.8%, contains 50 ppm Amylene
Chloroform, puriss. p.a., ACS reagent, >=99.8% (chloroform + ethanol, GC)
Chloroform, ReagentPlus(R), >=99.8%, contains 0.5-1.0% ethanol as stabilizer
Residual Solvent Class 2 - Chloroform, United States Pharmacopeia (USP) Reference Standard
200-663-8
Chloroform, ACS spectrophotometric grade, >=99.8%, contains 0.5-1.0% ethanol as stabilizer
Chloroform, contains ethanol as stabilizer, meets analytical specification of DAB9, BP, 99-99.4% (GC)
Residual Solvent - Chloroform, Pharmaceutical Secondary Standard; Certified Reference Material
Solubility of Chloroform (CHCl3)
Chloroform, known chemically as trichloromethane, demonstrates some intriguing aspects regarding its solubility:
In summary, while chloroform exhibits limited water solubility, its favorable interaction with organic solvents renders it a versatile tool in chemical synthesis and analysis. Understanding these solubility properties is crucial for effective utilization in various chemical processes.