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Mebendazole

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Identification
Molecular formula
C16H13N3O3
CAS number
31431-39-7
IUPAC name
diethyl-[2-[2-(2-morpholinoethyl)benzimidazol-1-yl]ethyl]ammonium;chloride
State
State

At room temperature, mebendazole is typically in a solid, crystalline state.

Melting point (Celsius)
288.00
Melting point (Kelvin)
561.15
Boiling point (Celsius)
420.00
Boiling point (Kelvin)
693.15
General information
Molecular weight
295.37g/mol
Molar mass
295.3780g/mol
Density
1.5000g/cm3
Appearence

Mebendazole appears as an odorless, white to slightly yellowish powder. It is practically insoluble in water, slightly soluble in methanol and insoluble in ether. It is crystalline in nature.

Comment on solubility

Solubility of Diethyl-[2-[2-(2-morpholinoethyl)benzimidazol-1-yl]ethyl]ammonium Chloride

The solubility of diethyl-[2-[2-(2-morpholinoethyl)benzimidazol-1-yl]ethyl]ammonium chloride can be characterized by several important factors:

  • Polarity: Being a quaternary ammonium compound, the presence of the positively charged ammonium group combined with the benzimidazole structure significantly influences solubility in polar solvents.
  • Solvent Interaction: This compound is expected to exhibit good solubility in water due to its ionic character, enabling favorable interactions with water molecules. Additionally, it may show varying solubility in organic solvents.
  • Temperature Dependence: As with many salts, solubility may increase with temperature, allowing greater dissolution at elevated temperatures.
  • Concentration Effects: At high concentrations, the solubility might reach its limit leading to precipitation. This necessitates careful consideration during formulation.

In conclusion, while diethyl-[2-[2-(2-morpholinoethyl)benzimidazol-1-yl]ethyl]ammonium chloride is likely to be soluble in both polar and nonpolar environments, the degree of its solubility will depend on factors such as temperature, solvent type, and concentration. Understanding these parameters is crucial for applications involving this compound.

Interesting facts

Interesting Facts about Diethyl-[2-[2-(2-morpholinoethyl)benzimidazol-1-yl]ethyl]ammonium; Chloride

Diethyl-[2-[2-(2-morpholinoethyl)benzimidazol-1-yl]ethyl]ammonium; chloride is a fascinating compound with significant implications in various fields, particularly in medicinal chemistry and pharmacology. Here are some intriguing aspects of this compound:

  • Pharmacological Potential: The structure of this compound indicates potential applications in drug development, particularly because the benzimidazole moiety is commonly found in several pharmaceutical agents. Compounds containing this core are renowned for their anti-parasitic, anti-viral, and anti-cancer properties.
  • Quaternary Ammonium Compounds: As a quaternary ammonium compound, it has a permanent positive charge, which enhances solubility in water and biological fluids. This property is essential for its performance in biological systems.
  • Adoption in Research: Due to the presence of the morpholino group, this compound may exhibit interesting biological interactions, making it a subject of study for new therapeutic agents targeting various diseases.
  • Diverse Functionalities: The versatility of the compound highlights the utility of substituted benzimidazoles in the chemical landscape. These structures can mimic natural biological molecules, providing a platform for designing selective receptors or inhibitors.
  • Interactions with Cellular Targets: The amine functionalities in this compound can facilitate interactions with cellular targets, such as proteins and nucleic acids, making it a candidate for further exploration in molecular biology.

In summary, diethyl-[2-[2-(2-morpholinoethyl)benzimidazol-1-yl]ethyl]ammonium; chloride not only showcases the richness of synthetic organic chemistry but also embodies the potential for groundbreaking advancements in therapeutic interventions. Its unique structural features may pave the way for novel treatments that could benefit various medical fields.

Synonyms
1-(2-(Diethylamino)ethyl)-2-(2-morpholinoethyl)benzimidazole hydrochloride
19809-25-7
BENZIMIDAZOLE, 1-(2-(DIETHYLAMINO)ETHYL)-2-(2-MORPHOLINOETHYL)-, HYDROCHLORIDE
RefChem:325802