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Bromhexine

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Identification
Molecular formula
C14H20BrN3O3S
CAS number
611-75-6
IUPAC name
diethyl-[2-[[2-hydroxy-2-phenyl-2-(2-thienyl)acetyl]amino]ethyl]-methyl-ammonium;bromide
State
State

At room temperature, bromhexine is typically a solid. It is commonly used in its hydrochloride salt form for medicinal purposes, particularly in cough syrups and pills. The compound is stable under normal conditions but should be stored in a cool, dry place.

Melting point (Celsius)
237.00
Melting point (Kelvin)
510.15
Boiling point (Celsius)
322.80
Boiling point (Kelvin)
595.95
General information
Molecular weight
412.38g/mol
Molar mass
412.3810g/mol
Density
1.4200g/cm3
Appearence

Bromhexine, typically encountered as bromhexine hydrochloride in pharmaceutical preparations, appears as a white or slightly yellowish powder. It is often supplied in tablet form or as a liquid for oral administration. The powder is crystalline, fine, and hygroscopic, meaning it tends to absorb moisture from the air.

Comment on solubility

Solubility Characteristics of Diethyl-[2-[[2-hydroxy-2-phenyl-2-(2-thienyl)acetyl]amino]ethyl]-methyl-ammonium Bromide

The solubility of diethyl-[2-[[2-hydroxy-2-phenyl-2-(2-thienyl)acetyl]amino]ethyl]-methyl-ammonium bromide is influenced by its complex molecular structure and the presence of both polar and nonpolar elements. Generally, we can consider the following aspects of its solubility:

  • Polar Components: The ammonium group within the compound enhances the solubility in polar solvents, such as water, due to ion-dipole interactions.
  • Hydrophobic Groups: The thienyl rings contribute hydrophobic characteristics, which may limit solubility in pure aqueous solutions but enhance interactions with organic solvents.
  • Hydrogen Bonding: With the presence of hydroxyl (-OH) groups, the molecule has the potential for hydrogen bonding with water, aiding in solubility.

In essence, the solubility profile can be described as:

  1. High solubility in polar solvents due to ionic nature.
  2. Reduced solubility in nonpolar solvents considering the hydrophobic sections.

To summarize, one could say, "The solubility of this compound is a dance between its ionic, polar nature and the hydrophobic characteristics of its organic functional groups." This intricate balance makes it an intriguing compound for various applications in chemical science.

Interesting facts

Interesting Facts about Diethyl-[2-[[2-hydroxy-2-phenyl-2-(2-thienyl)acetyl]amino]ethyl]-methyl-ammonium Bromide

Diethyl-[2-[[2-hydroxy-2-phenyl-2-(2-thienyl)acetyl]amino]ethyl]-methyl-ammonium bromide, often referred to as DEPTA, is a fascinating compound that belongs to a class of quaternary ammonium salts. These compounds are known for their versatility and unique properties, making them of great interest in various scientific fields. Here are some engaging points to consider:

  • Biological Activity: DEPTA has been studied for its potential biological applications, particularly in pharmacology. Its structure suggests that it may interact with biological membranes and exhibit antimicrobial properties.
  • Structural Complexity: The compound presents a unique molecular architecture, featuring both thienyl and phenyl groups. This complexity is significant because it allows for a diverse range of chemical interactions.
  • Hydrogen Bonding Potential: The presence of hydroxyl (-OH) groups in its structure suggests the ability to form hydrogen bonds, which can enhance its solubility and reactivity in biological systems.
  • Applications in Organic Synthesis: DEPTA can serve as an excellent intermediate in organic synthesis. Its quaternary ammonium nature may facilitate the formation of various derivatives, expanding its utility in chemical research.
  • Insights into Ion Exchange: As a quaternary ammonium salt, DEPTA demonstrates intriguing ion exchange characteristics. This property could be exploited in separations and purification processes in chemical engineering.

In summary, diethyl-[2-[[2-hydroxy-2-phenyl-2-(2-thienyl)acetyl]amino]ethyl]-methyl-ammonium bromide is not just a compound with a complex name, but a molecule rich with potential. As research continues to uncover its properties and applications, DEPTA could pave the way for advancements in medicinal chemistry and materials science. Its multifaceted nature serves as a reminder of the intricate connections between structure and function in the realm of chemical compounds.

Synonyms
FC 217
26058-58-2
Ammonium, diethyl(2-(alpha-hydroxy-alpha-phenyl-2-thiopheneacetamido)ethyl)methyl-, bromide
RefChem:319212