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Amikacin

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Identification
Molecular formula
C22H55ClN2O2Si
CAS number
37517-28-5
IUPAC name
diethyl-[2-[3-hydroxy-3-methyl-2-(4-trimethylsilylphenyl)butanoyl]oxyethyl]ammonium;chloride
State
State

At room temperature, Amikacin is typically found in a solid state as a crystalline powder. This makes it suitable for use in pharmaceutical formulations where precise dosing and dissolution rates are necessary.

Melting point (Celsius)
165.50
Melting point (Kelvin)
438.65
Boiling point (Celsius)
297.15
Boiling point (Kelvin)
570.30
General information
Molecular weight
586.65g/mol
Molar mass
586.6460g/mol
Density
1.1700g/cm3
Appearence

The compound typically appears as a white crystalline powder, indicating high purity and absence of contaminants. The appearance of the compound can suggest its form, whether it's a powder, crystal, or amorphous solid, which is essential for identification and usage in applications.

Comment on solubility

Solubility of Diethyl-[2-[3-hydroxy-3-methyl-2-(4-trimethylsilylphenyl)butanoyl]oxyethyl]ammonium;chloride

The solubility of the compound diethyl-[2-[3-hydroxy-3-methyl-2-(4-trimethylsilylphenyl)butanoyl]oxyethyl]ammonium chloride can be characterized by a few key factors:

  • Polarity: The presence of both hydrophobic and hydrophilic functional groups suggests a complex solubility profile. Its ammonium group enhances its solubility in polar solvents, such as water.
  • Hydrogen bonding: The hydroxyl group (-OH) allows for significant hydrogen bonding with water, which can improve solubility.
  • Ionization: Being a quaternary ammonium compound, it tends to be ionized, further enhancing its dissolution in aqueous solutions.
  • Temperature dependence: As with many ionic compounds, the solubility may increase with temperature due to enhanced molecular motion.

As a result, this compound is expected to exhibit good solubility in polar solvents while potentially having lower solubility in non-polar solvents. Its intricate structure and functional groups highlight the importance of considering both chemical interactions and environmental conditions when assessing solubility.

Interesting facts

Diethyl-[2-[3-hydroxy-3-methyl-2-(4-trimethylsilylphenyl)butanoyl]oxyethyl]ammonium Chloride

This compound is a fascinating example of a quaternary ammonium salt, which showcases the versatility and importance of ammonium derivatives in both organic and medicinal chemistry. Quaternary ammonium compounds are well-known for their antibacterial, antifungal, and antiviral properties, making them critical in the development of various pharmaceuticals and personal care products.

Key Characteristics and Applications:

  • Amphiphilic Nature: Due to its unique structure, this compound exhibits both hydrophilic and hydrophobic characteristics, allowing it to interact favorably with biological membranes.
  • Biological Activity: Similar compounds are frequently studied for their role in drug delivery systems because they can facilitate the transport of therapeutic agents across cell membranes.
  • Silicon Modification: The presence of the trimethylsilyl group enhances the compound’s stability and alters its reactivity, leading to potential applications in advanced material synthesis.
  • Potential for Targeted Therapy: The specific modifications in its structure make it a candidate for targeted drug formulations that can selectively interact with certain cells, such as tumor cells.

As we delve deeper into the study of this compound, we uncover the potential it holds not only in medicinal chemistry but also in material science and nanotechnology. Its ability to interact with lipids and proteins highlights its importance in understanding biochemical pathways and developing new therapeutic strategies. In the words of famous chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas." This compound embodies the ingenuity of combining various functional groups to create a substance with numerous possible applications.


Overall, the study of Diethyl-[2-[3-hydroxy-3-methyl-2-(4-trimethylsilylphenyl)butanoyl]oxyethyl]ammonium chloride opens doors to innovative research avenues, broadening the scope of chemical exploration in both academic and industrial settings.

Synonyms
20119-47-5
Butyric acid, 3-hydroxy-3-methyl-2-(p-(trimethylsilyl)phenyl)-, 2-(diethylamino)ethyl ester, hydrochloride
3-Hydroxy-3-methyl-2-(p-(trimethylsilyl)phenyl)butyric acid 2-(diethylamino)ethyl ester HCl
RefChem:331279