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Tamoxifen citrate

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Identification
Molecular formula
C26H29NO2
CAS number
54965-24-1
IUPAC name
diethyl-[2-[4-(1-hydroxy-2-phenyl-tetralin-1-yl)phenoxy]ethyl]ammonium;chloride
State
State

At room temperature, Tamoxifen citrate is in a solid state.

Melting point (Celsius)
140.00
Melting point (Kelvin)
413.20
Boiling point (Celsius)
384.60
Boiling point (Kelvin)
657.80
General information
Molecular weight
563.64g/mol
Molar mass
563.6400g/mol
Density
1.1292g/cm3
Appearence

Tamoxifen citrate is typically found as a white or off-white crystalline powder.

Comment on solubility

Solubility of Diethyl-[2-[4-(1-hydroxy-2-phenyl-tetralin-1-yl)phenoxy]ethyl]ammonium;chloride

The solubility of diethyl-[2-[4-(1-hydroxy-2-phenyl-tetralin-1-yl)phenoxy]ethyl]ammonium;chloride can be influenced by several factors due to its complex chemical structure. Here are some key points regarding its solubility:

  • Polar vs. Nonpolar: The presence of the ammonium group suggests that this compound may have some degree of polarity, which typically enhances solubility in polar solvents such as water.
  • Hydrophobic Elements: The hydrophobic phenyl groups may hinder solubility in a purely aqueous environment, which could lead to a variable solubility depending on the solvent used.
  • Temperature Dependency: Like many ionic compounds, the solubility of this compound could increase with temperature, as higher temperatures often promote dissociation.

In conclusion, while general trends can be observed, the actual solubility of this compound would need to be determined experimentally, as it may exhibit unique characteristics based on its specific interactions with various solvents.

Interesting facts

Interesting Facts about Diethyl-[2-[4-(1-hydroxy-2-phenyl-tetralin-1-yl)phenoxy]ethyl]ammonium Chloride

This intriguing compound belongs to the family of quaternary ammonium salts, known for their diverse applications in biochemical and pharmaceutical settings. Its unique structure features a **tetralin** backbone, which is a bicyclic aromatic compound making it particularly interesting for medicinal chemistry.

  • Pharmaceutical Applications: Compounds like this one play essential roles in drug formulation. They often act as ion-pairing agents, enhancing the solubility and bioavailability of active pharmaceutical ingredients.
  • Biological Activity: The phenolic group in its structure suggests potential for interacting with biological targets, possibly influencing various signaling pathways within cells.
  • Structure-Activity Relationship (SAR): Understanding how modifications to the tetralin and phenyl components affect activity is crucial in drug design, leading to more effective and selective therapeutic agents.

Moreover, the incorporation of the diethylammonium moiety may impart properties that influence membrane permeability and ligand-receptor interactions, making it a subject of interest for studies aimed at understanding drug efficacy. As scientists, we often explore how the geometrical and electronic properties of such compounds impact their behavior in biological systems, and this compound provides ample opportunity for exploration.

In summary: The complexities of diethyl-[2-[4-(1-hydroxy-2-phenyl-tetralin-1-yl)phenoxy]ethyl]ammonium chloride not only promote its utility in medicinal chemistry but also stimulate ongoing research into its potential therapeutic benefits. It's a prime example of how chemical structure translates to biological function.

Synonyms
1-Naphthol, 1,2,3,4-tetrahydro-1-(p-(2-(diethylamino)ethoxy)phenyl)-2-phenyl-, hydrochloride
1820-38-8
1,2,3,4-Tetrahydro-1-(p-(2-(diethylamino)ethoxy)phenyl)-2-phenyl-1-naphthol hydrochloride
1-(p-(2-Diethylaminoethoxy)phenyl)-1,2,3,4-tetrahydro-2-phenyl-1-naphthol hydrochloride