Skip to main content

Quinapril

ADVERTISEMENT
Identification
Molecular formula
C25H30ClN3O3
CAS number
126370-67-0
IUPAC name
diethyl-[2-[4-methyl-2-(2-methyl-4-oxo-quinazolin-3-yl)benzoyl]oxyethyl]ammonium;chloride
State
State

At room temperature, quinapril hydrochloride is typically found in solid form.

Melting point (Celsius)
120.00
Melting point (Kelvin)
393.15
Boiling point (Celsius)
462.15
Boiling point (Kelvin)
735.15
General information
Molecular weight
441.00g/mol
Molar mass
440.9970g/mol
Density
1.2350g/cm3
Appearence

Quinapril hydrochloride typically appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of Diethyl-[2-[4-methyl-2-(2-methyl-4-oxo-quinazolin-3-yl)benzoyl]oxyethyl]ammonium Chloride

The solubility of diethyl-[2-[4-methyl-2-(2-methyl-4-oxo-quinazolin-3-yl)benzoyl]oxyethyl]ammonium chloride is an intriguing subject, particularly due to its complex structure. Here are some key points to consider:

  • Solvent Compatibility: This compound is likely to be soluble in polar solvents, such as water and alcohols, due to the presence of the ammonium group which enhances solvation.
  • Influence of Ionic Nature: The chloride ion contributes to its ionic nature, potentially increasing solubility in aqueous solutions.
  • Hydrophobic Interactions: The presence of hydrophobic groups in its structure may reduce solubility in non-polar solvents, making it less soluble in organic solvents like hexane.
  • Temperature Effects: Solubility can be affected by temperature; generally, the solubility of salts increases with increasing temperature.

As stated in the literature, "the solubility of compounds in specific solvents is governed by their molecular structure and the nature of the solvent, highlighting the significance of molecular interactions." This principle applies strongly to diethyl-[2-[4-methyl-2-(2-methyl-4-oxo-quinazolin-3-yl)benzoyl]oxyethyl]ammonium chloride, making its solubility a key factor in its application and reactivity.

Interesting facts

Interesting Facts about Diethyl-[2-[4-methyl-2-(2-methyl-4-oxo-quinazolin-3-yl)benzoyl]oxyethyl]ammonium Chloride

This fascinating compound is a member of the class of quaternary ammonium salts, which are widely recognized for their diverse applications in pharmaceuticals and biochemistry. Here are some key points to consider:

  • Pharmacological Potential: The unique structure of diethyl-[2-[4-methyl-2-(2-methyl-4-oxo-quinazolin-3-yl)benzoyl]oxyethyl]ammonium chloride suggests potential therapeutic applications, particularly in targeting specific biological pathways.
  • Quinazoline Core: The incorporation of a quinazoline moiety into its structure is noteworthy, as compounds containing quinazoline exhibit a variety of biological activities, including anti-cancer and anti-inflammatory effects.
  • Ammonium Salt Characteristics: As a quaternary ammonium compound, it can interact with biological membranes, influencing cell permeability and offering unique mechanisms for drug delivery.
  • Structure-Activity Relationship: The intricate positioning of various functional groups around the quinazoline framework allows for extensive structure-activity relationship studies, which are essential for optimizing pharmaceutical efficacy.
  • Research Relevance: This compound is of interest in the fields of medicinal chemistry and drug design, emphasizing the importance of synthesizing novel compounds that can enhance therapeutic efficacy and minimize side effects.

As researchers delve deeper into the properties and functions of compounds like this, it becomes evident that the limits of pharmaceutical innovation are continually expanding. In the words of a famed chemist, "Chemistry is the art of understanding the profound simplicities underlying complex systems." This compound exemplifies that sentiment.


Synonyms
2619-08-1
Benzoic acid, 4-methyl-3-(2-methyl-4-oxo-3(4H)-quinazolinyl)-, 2-(diethylamino)ethyl ester, monohydrochloride
2-Metil-3-(3-carbossietildietilammino-6-metil-fenil)-4-chinazolone cloridrate [Italian]
4-Methyl-3-(2-methyl-4-oxo-3(4H)-quinazolinyl)benzoic acid 2-(diethylamino)ethyl ester HCl
2-Metil-3-(3-carbossietildietilammino-6-metil-fenil)-4-chinazolone cloridrate