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Prucalopride succinate

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Identification
Molecular formula
C23H34ClN5O3
CAS number
179474-81-8
IUPAC name
diethyl-[2-[5-nitro-2-(2-pyrrolidin-1-ylethyl)benzimidazol-1-yl]ethyl]ammonium;chloride
State
State

Prucalopride succinate exists in a solid state at room temperature, commonly prepared in crystalline form for pharmaceutical use.

Melting point (Celsius)
188.50
Melting point (Kelvin)
461.60
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
367.88g/mol
Molar mass
367.8760g/mol
Density
1.4000g/cm3
Appearence

Prucalopride succinate typically appears as a white to off-white crystalline powder when in solid form. Its appearance may vary depending on the purity and specific formulation.

Comment on solubility

Solubility of diethyl-[2-[5-nitro-2-(2-pyrrolidin-1-ylethyl)benzimidazol-1-yl]ethyl]ammonium;chloride

The solubility of diethyl-[2-[5-nitro-2-(2-pyrrolidin-1-ylethyl)benzimidazol-1-yl]ethyl]ammonium;chloride is influenced by its unique molecular structure, which incorporates both hydrophobic and hydrophilic components. Here are several key points regarding its solubility:

  • Polarity: The presence of the ammonium group suggests that the compound is likely to be soluble in polar solvents, particularly water, due to its ionic nature.
  • Functional Groups: The nitro and pyrrolidinyl substituents can affect solubility significantly. These groups may offer sites for hydrogen bonding, enhancing solubility in polar solvents.
  • Temperature Dependence: As with many compounds, solubility is typically temperature-dependent, potentially increasing at higher temperatures.
  • Solvent Interaction: The compound may exhibit variable solubility in organic solvents, depending upon their polarity. For example, it may be less soluble in non-polar solvents.

As a general note, experimental determination is often necessary to precisely quantify solubility in various solvents. This assessment can provide critical insight into applications and reactivity in different environments.

Interesting facts

Interesting Facts About Diethyl-[2-[5-nitro-2-(2-pyrrolidin-1-ylethyl)benzimidazol-1-yl]ethyl]ammonium;chloride

Diethyl-[2-[5-nitro-2-(2-pyrrolidin-1-ylethyl)benzimidazol-1-yl]ethyl]ammonium;chloride, a compound rich in biological significance, is gaining attention in various fields, especially pharmacology and medicinal chemistry. Here are some fascinating aspects of this compound:

  • Pharmacological Potential: The presence of the benzimidazole moiety is notable as these structures are often linked to pharmacological activity, including anti-parasitic and anti-cancer properties.
  • Design Features: The incorporation of a nitro group and the pyrrolidine ring structure suggests enhanced interactions with biological targets, which can influence the compound’s efficacy as a drug.
  • Stability and Solubility: As a quaternary ammonium salt, where the ammonium ion is balanced by chloride, this compound typically exhibits increased stability and favorable solubility in aqueous solutions, making it suitable for various applications.
  • Research Applications: Scientists are interested in the use of this compound as a potential therapeutic agent. Ongoing research focuses on understanding its mechanisms of action and exploring its capability to inhibit specific biological pathways.
  • Structure Activity Relationship (SAR): The structural variations in this compound provide an opportunity to investigate how modifications can enhance its pharmacological profile, paving the way for the development of novel therapeutics.

Quoting a renowned chemist, “The beauty of compound design lies in the endless possibilities that structure can unveil.” This compound exemplifies that beauty through its unique arrangement of functional groups and potential applications.

In conclusion, Diethyl-[2-[5-nitro-2-(2-pyrrolidin-1-ylethyl)benzimidazol-1-yl]ethyl]ammonium;chloride stands as a prime example of innovation in drug design, inviting further exploration and discovery in the realm of chemistry and medicine.

Synonyms
Benzimidazole, 1-(2-(diethylamino)ethyl)-5-nitro-2-(2-(pyrrolidin-1-yl)ethyl)-, hydrochloride
1-(2-(Diethylamino)ethyl)-5-nitro-2-(2-(pyrrolidin-1-yl)ethyl)benzimidazole hydrochloride
19809-13-3
RefChem:325809