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Neostigmine methylsulfate

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Identification
Molecular formula
C22H32N2O5S
CAS number
51-60-5
IUPAC name
diethyl-[2-(phenylcarbamoyloxy)-1-(phenylcarbamoyloxymethyl)ethyl]ammonium;4-methylbenzenesulfonate
State
State

Neostigmine methylsulfate is a solid at room temperature, typically provided as a stable crystalline powder. It is often used in its solid form for pharmaceutical formulations.

Melting point (Celsius)
142.00
Melting point (Kelvin)
415.15
Boiling point (Celsius)
275.00
Boiling point (Kelvin)
548.15
General information
Molecular weight
565.68g/mol
Molar mass
565.6800g/mol
Density
1.3000g/cm3
Appearence

Neostigmine methylsulfate appears as a white to off-white crystalline powder. It is typically supplied as a purified solid for pharmaceutical applications.

Comment on solubility

Solubility of diethyl-[2-(phenylcarbamoyloxy)-1-(phenylcarbamoyloxymethyl)ethyl]ammonium;4-methylbenzenesulfonate

The solubility of diethyl-[2-(phenylcarbamoyloxy)-1-(phenylcarbamoyloxymethyl)ethyl]ammonium;4-methylbenzenesulfonate presents a unique profile due to its complex molecular structure. This compound features a quaternary ammonium salt, which often impacts its solubility in various solvents.

  • Aqueous Solubility: Generally, quaternary ammonium salts tend to be highly soluble in water due to their ionic nature. However, the presence of bulky organic groups may influence the overall solubility.
  • Organic Solvents: The compound may exhibit different solubility characteristics in organic solvents such as alcohols or DMSO. The hydrophobic phenyl groups contribute to variations in solubility.
  • Temperature Effects: Like many chemical compounds, solubility can increase with temperature, making it essential to consider temperature variations in solubility studies.

Furthermore, it's significant to highlight that factors such as pH and the presence of other ions in solution can greatly influence solubility. Conducting solubility tests in a variety of conditions can yield meaningful insights. Always remember that “solubility is a complex interplay of thermodynamics and molecular interactions.”
Understanding the specific solubility characteristics of this compound is crucial for its application in fields such as pharmaceuticals and materials science.

Interesting facts

Interesting Facts about Diethyl-[2-(phenylcarbamoyloxy)-1-(phenylcarbamoyloxymethyl)ethyl]ammonium; 4-methylbenzenesulfonate

This compound, a fascinating example of an organic ammonium salt, showcases intricate structural features and remarkable biochemical potential. Here are some compelling insights:

  • Dual Functionality: The presence of both diethylammonium and sulfonate moieties allows this compound to act as a surfactant, facilitating its use in various applications including drug delivery and emulsification.
  • Bioconjugation: The phenylcarbamoyl groups present in the molecule can participate in bioconjugation reactions, which are essential in the development of targeted therapies.
  • Tunable Properties: The strategic placement of functional groups enables the modification of the compound's solubility and reactivity, making it a valuable candidate for further chemical exploration.
  • Potential Therapeutic Uses: Due to its unique structure, it may possess pharmacological properties that are yet to be fully explored, with implications for medicinal chemistry and the development of new therapeutic agents.
  • Advanced Synthesis: The complex synthesis route reflects a challenge in organic chemistry, embodying concepts such as nucleophilic substitution and esterification that are foundational in the synthesis of sophisticated compounds.

In the words of a renowned chemist, *“The beauty of chemistry lies not just in the compounds themselves, but in the endless possibilities they provide for innovation.”* This compound certainly embodies that sentiment, offering a glimpse into the limitless potential of chemical research.

Ultimately, diethyl-[2-(phenylcarbamoyloxy)-1-(phenylcarbamoyloxymethyl)ethyl]ammonium; 4-methylbenzenesulfonate is a testament to the creativity and complexity inherent in the world of chemistry.

Synonyms
2-(Diethylamino)trimethylene carbanilate tosylate
CARBANILIC ACID, 2-(DIETHYLAMINO)TRIMETHYLENE ESTER, TOSYLATE
27467-08-9
1,3-Propanediol, 2-(diethylamino)-, dicarbanilate, tosylate
DTXSID40181887
RefChem:332935
DTXCID80104378