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Nifedipine

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Identification
Molecular formula
C17H18N2O6
CAS number
21829-25-4
IUPAC name
diethyl 2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate
State
State

At room temperature, nifedipine is in a solid state, specifically as a crystalline powder, which is typical for many pharmaceutical compounds before they are processed into dosage forms like tablets.

Melting point (Celsius)
172.00
Melting point (Kelvin)
445.15
Boiling point (Celsius)
507.10
Boiling point (Kelvin)
780.30
General information
Molecular weight
346.34g/mol
Molar mass
346.3360g/mol
Density
1.3330g/cm3
Appearence

Nifedipine is a yellow crystalline powder. It is often used in the pharmaceutical industry and appears in tablet or capsule form when used as a medication.

Comment on solubility

Solubility of Diethyl 2,6-Dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate

Diethyl 2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate can exhibit variable solubility characteristics depending on the solvent used. Notably:

  • Polar solvents: The presence of carboxylate groups in its structure generally increases solubility in polar solvents such as water or methanol due to hydrogen bonding.
  • Nonpolar solvents: Conversely, this compound may show lower solubility in nonpolar solvents like hexane due to a lack of interaction between the nonpolar solvent molecules and the polar functional groups.
  • Solvent mixtures: Mixtures of polar and nonpolar solvents may aid in achieving optimal solubility, significantly affecting the compound's behavior in various chemical processes.

As with many organic compounds, factors such as temperature and pH can further influence solubility. Understanding the solubility properties is crucial for applications in pharmaceuticals and chemical synthesis, enabling effective formulation and utilization in various contexts.

Interesting facts

Interesting Facts About Diethyl 2,6-Dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate

Diethyl 2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate is a fascinating compound that showcases the rich diversity of organic chemistry. It belongs to the class of dihydropyridines, which are known for their significant role in medicinal chemistry.

Key Characteristics:

  • Biological Importance: Dihydropyridines are often utilized as calcium channel blockers, which are crucial in the treatment of cardiovascular diseases. This compound, in particular, may exhibit similar properties, indicating its potential therapeutic applications.
  • Synthetic Versatility: The synthesis of this compound involves various chemical reactions that highlight the creativity in organic synthesis, particularly reactions that form functional groups such as esters and carboxylic acids.
  • Structural Features: The presence of multiple substituents, including diethyl and phenyl groups, contributes to its distinct chemical properties and can enhance its reactivity and stability.

The compound's structural diversity makes it a subject of interest for researchers looking for new pharmacological agents. Notably, its unique structure can also serve as a scaffold for the development of new drugs, enabling chemists to modify it for enhanced efficacy or reduced side effects.

Chemistry in Action:

  • This compound can exhibit various electronic effects due to its substituents, influencing its chemical behavior.
  • Researchers often study dihydropyridine compounds to understand their role in biological processes, particularly in ion transport and signal transduction.

In conclusion, diethyl 2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate is more than just an organic compound; it is a testament to the intricacies of chemical synthesis and the potential for innovation in drug discovery. As a chemistry student or a scientist, exploring such compounds opens up avenues of understanding that can lead to significant advances in healthcare and materials science.

Synonyms
1165-06-6
diethyl 2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate
E97NK89OBH
3,5-PYRIDINEDICARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-4-PHENYL-, DIETHYL ESTER
NSC-63467
DTXSID50151399
1,4-Dihydro-2,6-dimethyl-4-phenyl-3,5-pyridinedicarboxylic acid diethyl ester
Diethyl 4-phenyl-1,4-dihydro-2,6-lutidine-3,5-dicarboxylate
2,6-DIMETHYL-3,5-DICARBETHOXY-4-PHENYL-1,4-DIHYDROPYRIDINE
3,5-DICARBETHOXY-2,6-DIMETHYL-4-PHENYL-1,4-DIHYDROPYRIDINE
2,6-DIMETHYL-3,5-BIS(ETHOXYCARBONYL)-4-PHENYL-1,4-DIHYDROPYRIDINE
2,6-DIMETHYL-3,5-DIETHOXYCARBONYL-6-PHENYL-1,4-DIHYDROPYRIDINE
DIETHYL 1,4-DIHYDRO-2,6-DIMETHYL-4-PHENYL-3,5-PYRIDINEDICARBOXYLATE
3,5-PYRIDINEDICARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-4-PHENYL-, 3,5-DIETHYL ESTER
DIHYDRO-2,6-DIMETHYL-4-PHENYL-3,5-PYRIDINEDICARBOXYLIC ACID, DIETHYL ETHER, 1,4-
DTXCID3073890
682-914-5
3,5-diethyl 2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate
DIETHYL2,6-DIMETHYL-4-PHENYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE
3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-phenyl-, 3,5-diethyl ester
CHEMBL1099205
Diethyl-2,6-dimethyl-4-phenyl-1,4-dihydro-3,5-pyridine dicarboxylate
NSC 63467
BRN 0298941
MFCD00023119
UNII-E97NK89OBH
Isocinchomeronic acid, 1,4-dihydro-2,6-dimethyl-4-phenyl-, diethyl ester
NCIOpen2_008050
Oprea1_065438
Oprea1_364749
5-22-04-00265 (Beilstein Handbook Reference)
SCHEMBL3027412
BAA16506
NSC63467
BDBM50073961
STK285537
AKOS000296758
HY-W267959
NS-00071
CS-0313307
EU-0000289
WLN: T6M DHJ B1 CVO2 DR& EVO2 F1
G81346
Diethyl-2,4-dihydro-3,5-pyridine dicarboxylate
AC-907/25005457
AE-641/30076029
EN300-26478975
SR-01000390740
SR-01000390740-1
Z56791242
3, 1,4-dihydro-2,6-dimethyl-4-phenyl-, diethyl ester
F0037-4531
4-Phenyl-3,5-dicarbethoxy-2,6-dimethyl-1,4-dihydropyridine
diethyl 1,4-dihydro-2,6-dimethyl-4-phenylpyridine-3,5-dicarboxylate
Diethyl 2,6-dimethyl-4-phenyl-1,4-dihydro-3,5-pyridinedicarboxylate
Diethyl 4-phenyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Ethyl (4-phenyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate)
Isocinchomeronic acid, 1,4-dihydro-2,6-dimethyl-4-phenyl-, diethylester
Isocinchomeronic acid,4-dihydro-2,6-dimethyl-4-phenyl-, diethyl ester