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Furosemide

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Identification
Molecular formula
C12H11ClN2O5S
CAS number
54-31-9
IUPAC name
diethyl-[4-[2-(2-furylmethyl)-3-(1-naphthyl)propanoyl]oxybutyl]ammonium;2-hydroxy-2-oxo-acetate
State
State

At room temperature, furosemide exists as a solid. It is commonly available in pharmaceutical preparations as tablets or sometimes as a powder for oral or intravenous administration.

Melting point (Celsius)
206.00
Melting point (Kelvin)
479.15
Boiling point (Celsius)
235.00
Boiling point (Kelvin)
508.15
General information
Molecular weight
330.74g/mol
Molar mass
330.7440g/mol
Density
1.3280g/cm3
Appearence

Furosemide is typically a white to off-white crystalline powder. It is odorless or may have a faint odor and is often used in the form of tablets for medical applications. The compound's crystalline nature contributes to its distinct appearance.

Comment on solubility

Solubility of Diethyl-[4-[2-(2-furylmethyl)-3-(1-naphthyl)propanoyl]oxybutyl]ammonium; 2-hydroxy-2-oxo-acetate

The solubility of the compound diethyl-[4-[2-(2-furylmethyl)-3-(1-naphthyl)propanoyl]oxybutyl]ammonium; 2-hydroxy-2-oxo-acetate can be complex due to its multifaceted structure. Factors influencing its solubility include:

  • Polar vs. Nonpolar: The compound contains both polar (e.g., hydroxyl and ammonium groups) and nonpolar (e.g., naphthyl and furan rings) regions, which can lead to varying solubility in different solvents.
  • Hydrogen Bonding: The presence of hydroxyl groups suggests potential for hydrogen bonding, which can enhance solubility in polar solvents such as water.
  • Organic Solvent Compatibility: Given its bulky and hydrophobic portions, it may exhibit increased solubility in organic solvents like ethanol or methanol.

In general, one might expect this compound to have moderate solubility in polar solvents, while being more soluble in certain nonpolar organic solvents. As stated in chemical solubility principles, “Like dissolves like,” indicating that solubility greatly depends on the matching of polarities between solute and solvent. Therefore, experimentally determining the solubility in various solvents would be essential to fully understand and optimize its applications in chemical formulations.

Interesting facts

Interesting Facts about Diethyl-[4-[2-(2-Furylmethyl)-3-(1-Naphthyl)propanoyl]oxybutyl]ammonium; 2-Hydroxy-2-Oxo-Acetate

This compound is a fascinating example of synthetic organic chemistry, where the combination of different functional groups leads to unique properties and potential applications. Here are some intriguing facts about this compound:

  • Complex Structure: The compound features a carefully constructed architecture that includes a quaternary ammonium moiety, which is known for its ability to interact with a variety of biological systems.
  • Biological Potential: The presence of a furylmethyl group suggests potential activity in pharmacology, as furans can play a role in drug development due to their ability to influence metabolic pathways.
  • Versatile Applications: Quaternary ammonium compounds like this one are often explored for uses such as antimicrobial agents, surfactants, and in formulations for various industries.
  • Synthetic Pathways: The synthesis of such compounds often involves multi-step reactions that can showcase the creativity and precision required in modern organic chemistry.

As a chemist studying compounds like this, one might draw from the following notable quote by Linus Pauling: "The best way to have a good idea is to have a lot of ideas." This encapsulates the experimental spirit that drives discoveries in complex synthetic compounds.

Due to its unique structure and potential applications, Diethyl-[4-[2-(2-Furylmethyl)-3-(1-Naphthyl)propanoyl]oxybutyl]ammonium; 2-Hydroxy-2-Oxo-Acetate represents an interesting intersection of organic chemistry and medicinal research, inviting further exploration in its properties and practical uses.

Synonyms
2-Furanpropionic acid, alpha-(1-naphthylmethyl)-, 4-(diethylamino)butyl ester, oxalate (1:1)
alpha-(1-Naphthylmethyl)-2-furanpropionic acid 4-(diethylamino)butyl ester oxalate (1:1)
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