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Papaverine Dihydrogen Phosphate

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Identification
Molecular formula
C20H21NO4·H2PO4
CAS number
61-25-6
IUPAC name
dihydrogen phosphate;1-[(4-ethoxy-3-methoxy-phenyl)methyl]-6,7-dimethoxy-3-methyl-isoquinolin-2-ium
State
State

Papaverine dihydrogen phosphate is a solid at room temperature. It is stable under recommended storage conditions and is typically stored in a cool, dry place to prevent degradation.

Melting point (Celsius)
140.00
Melting point (Kelvin)
413.15
Boiling point (Celsius)
745.30
Boiling point (Kelvin)
1 018.45
General information
Molecular weight
445.44g/mol
Molar mass
445.4420g/mol
Density
1.1900g/cm3
Appearence

Papaverine dihydrogen phosphate typically appears as a white to off-white crystalline powder. It may also be found as crystalline aggregates. Its state and form make it suitable for pharmaceutical use, particularly for manufacturing tablets and injections.

Comment on solubility

Solubility of Dihydrogen Phosphate; 1-[(4-ethoxy-3-methoxy-phenyl)methyl]-6,7-dimethoxy-3-methyl-isoquinolin-2-ium

The solubility of the compound dihydrogen phosphate; 1-[(4-ethoxy-3-methoxy-phenyl)methyl]-6,7-dimethoxy-3-methyl-isoquinolin-2-ium is a multifaceted topic that warrants exploration. Understanding solubility is crucial for anticipating a compound’s behavior in various environments, particularly in biological and pharmaceutical contexts.

Factors Influencing Solubility:

  • Polarity: The presence of both hydrophobic and hydrophilic groups in the compound may lead to variable solubility in different solvents.
  • Temperature: Typically, an increase in temperature can enhance solubility; however, the specific impact depends on the nature of the interactions within the compound.
  • pH Level: Dihydrogen phosphates are generally soluble in water; their solubility can be affected by the acidity or basicity of the solution.
  • Intermolecular Interactions: The presence of the isoquinolinium moiety often indicates a potential for hydrogen bonding, which can improve solubility in polar solvents.

It is important to note that, according to the principle of "like dissolves like," polar compounds are more likely to be soluble in polar solvents, whereas non-polar compounds prefer non-polar solvents. Thus, predicting solubility requires examining the entire molecular structure.

Overall, while dihydrogen phosphate; 1-[(4-ethoxy-3-methoxy-phenyl)methyl]-6,7-dimethoxy-3-methyl-isoquinolin-2-ium may exhibit some degree of solubility in aqueous solutions, its actual solubility should be experimentally determined to provide definitive insights.

Interesting facts

Interesting Facts About Dihydrogen Phosphate: 1-[(4-Ethoxy-3-methoxy-phenyl)methyl]-6,7-dimethoxy-3-methyl-isoquinolin-2-ium

Dihydrogen phosphate, particularly in the context of organic compounds like 1-[(4-ethoxy-3-methoxy-phenyl)methyl]-6,7-dimethoxy-3-methyl-isoquinolin-2-ium, presents a fascinating area of study in both chemistry and pharmacology. Here are some key points to consider:

  • Structure and Composition: This compound features a complex organic structure that includes an isoquinoline core, which is known for its diverse biological activities and presence in various natural products.
  • Versatility: The presence of functional groups, such as ethoxy and methoxy, enhances the compound's potential for various chemical reactions, making it an interesting subject for synthetic chemists.
  • Biological Relevance: Compounds containing isoquinoline rings have been explored for their potential pharmacological properties, including anti-cancer, anti-inflammatory, and anti-microbial activities, making them valuable in medicinal chemistry.
  • Coordination Chemistry: Dihydrogen phosphate ions can play a role in coordination chemistry, interacting with metals to form complexes, which can lead to applications in catalysis and materials science.

In studying this compound, it is important to consider its potential applications and implications in various fields:

  • Drug Development: The unique structural features might provide leads for developing new therapeutic agents.
  • Research Innovations: Understanding its reactivity could inspire innovative methodologies in organic synthesis.
  • Environmental Impact: Investigating its behavior in biological pathways could shed light on its environmental persistence and toxicity.

Overall, the exploration of dihydrogen phosphate in this complex organic form showcases the intricate relationship between structure and function in chemical compounds, emphasizing the importance of interdisciplinary approaches in modern chemistry.

Synonyms
Dioxylium phosphate
6670-95-7
1-(4-Ethoxy-3-methoxybenzyl)-6,7-dimethoxy-3-methylisoquinoline phosphate
Isoquinoline, 1-((4-ethoxy-3-methoxyphenyl)methyl)-6,7-dimethoxy-3-methyl-, phosphate
ISOQUINOLINE, 1-(4-ETHOXY-3-METHOXYBENZYL)-6,7-DIMETHOXY-3-METHYL-, PHOSPHATE