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Dihydroartemisinin

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Identification
Molecular formula
C15H24O5
CAS number
81496-81-3
IUPAC name
dimethyl (1R,9R,10R,11R,12S,19S)-12-ethyl-4-[(13S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10,11-dicarboxylate;sulfuric acid
State
State

At room temperature, dihydroartemisinin is a solid. It is stable under normal conditions of use and storage.

Melting point (Celsius)
182.00
Melting point (Kelvin)
455.15
Boiling point (Celsius)
330.00
Boiling point (Kelvin)
603.15
General information
Molecular weight
282.35g/mol
Molar mass
282.3490g/mol
Density
1.2900g/cm3
Appearence

Dihydroartemisinin appears as a white to off-white crystalline powder. It is characterized by its crystalline structure which reflects light, giving an appearance typical of many pharmaceutically active compounds.

Comment on solubility

Solubility of Dimethyl (1R,9R,10R,11R,12S,19S)-12-ethyl-4-[(13S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10,11-dicarboxylate; sulfuric acid

The solubility of this complex compound in various solvents can often be intricate due to its multi-cyclic structure and the presence of functional groups. The general trends in solubility can be summarized as follows:

  • Solvent Effects: The polar and non-polar characteristics of the solvent greatly influence solubility. For example:
    • Polar solvents like water may solvate molecules with polar groups, potentially enhancing solubility.
    • Non-polar solvents might be more favorable for solubilizing the hydrophobic regions of the molecule.
  • pH Sensitivity: The presence of acidic groups (such as carboxylic acids) can lead to variations in solubility depending on the pH of the solution.
  • Temperature Influence: Generally, increased temperature tends to increase solubility for most solids; however, exceptions may exist depending on the compound structure.

It is important to note that due to the specific structure of this compound, which contains multiple functional groups, solubility can vary widely. Therefore, empirical testing and solvent screening are often necessary to determine the optimal conditions for solubility. As always, understanding solubility is key for applications in drug formulation, materials science, and chemical processing.

Interesting facts

Interesting Facts about Dimethyl (1R,9R,10R,11R,12S,19S)-12-ethyl-4-[(13S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10,11-dicarboxylate; sulfuric acid

The compound you are inquiring about is a complex organic molecule with fascinating structural features and potential applications. Here are some noteworthy aspects:

  • Diverse Functionality: The presence of multiple functional groups, such as hydroxyl and carboxyl, offers a variety of reactivity possibilities, making this compound a subject of interest in organic synthesis.
  • Structural Complexity: This compound showcases a unique arrangement of rings and substituents, with pentacyclic and tetracyclic frameworks that contribute to its intricate stereochemistry.
  • Potential Biological Activity: Compounds of this nature often exhibit bioactivity, lending themselves to exploration in the fields of medicinal chemistry and pharmacology. The intricate structure can lead to novel biological interactions.
  • Applications in Material Science: Given its complex nature, there may be applications in developing advanced materials, including drug delivery systems or new polymers.
  • Research Opportunities: Chemists continue to study such compounds for insights into their potential in drug design and the development of new therapeutic agents.

In the words of renowned chemist Robert H. Grubbs, "The beauty of a molecule lies in both its structure and its function." This compound embodies that sentiment, as its intricate structure holds promise for various fields of research and application, thus encouraging further inquiry.

The exploration of such compounds pushes the boundaries of chemistry and encourages innovative thinking to unlock new possibilities in science.