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Erythromycin

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Identification
Molecular formula
C37H67NO13
CAS number
114-07-8
IUPAC name
dimethyl (1R,9R,10R,11R,12S,19S)-12-ethyl-4-[(13S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10,11-dicarboxylate
State
State

At room temperature, erythromycin exists as a solid, usually in the form of a crystalline powder. When exposed to air, it should be protected from moisture to maintain its stability and efficacy.

Melting point (Celsius)
135.00
Melting point (Kelvin)
408.15
Boiling point (Celsius)
215.00
Boiling point (Kelvin)
488.15
General information
Molecular weight
733.94g/mol
Molar mass
733.9370g/mol
Density
1.2485g/cm3
Appearence

Erythromycin is typically a white to off-white, crystalline powder. It is practically odorless or may have a faint characteristic odor. The substance is often encountered in its hydrate or base form and may be slightly hygroscopic.

Comment on solubility

Solubility of Dimethyl (1R,9R,10R,11R,12S,19S)-12-ethyl-4-[(13S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10,11-dicarboxylate

The solubility of complex organic compounds such as dimethyl (1R,9R,10R,11R,12S,19S)-12-ethyl-4-[(13S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10,11-dicarboxylate can be highly variable and is influenced by several factors:

  • Polarity: The presence of multiple functional groups (e.g., hydroxyl and carboxyl groups) generally increases solubility in polar solvents like water.
  • Hydrogen Bonding: Molecules with the ability to form hydrogen bonds tend to exhibit higher solubility in alcohols and similar solvents.
  • Size and Complexity: The large and intricate structure of this compound can hinder solubility due to steric effects, potentially making it less soluble in non-polar solvents.
  • pH Level: The ionization of certain groups can be dependent on the pH, affecting solubility. For instance, carboxylate groups may enhance solubility in basic conditions.

In summary, while the potential for solubility exists due to functional groups, one must consider the overall structure and interaction dynamics. The compound could be described as having variable solubility depending on the solvent used, and further empirical studies would be essential to ascertain specific solubility characteristics.

Interesting facts

Interesting Facts About Dimethyl (1R,9R,10R,11R,12S,19S)-12-ethyl-4-[(13S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10,11-dicarboxylate

This complex compound, often referred to for its extensive chemical structure, is a fascinating subject of study within the field of organic chemistry due to its intricate connectivity and potential biological activity. Here are some compelling aspects of this molecule:

  • Diverse Chemical Backbone: The compound features a unique fused ring system, consisting of multiple rings that contribute to its structural diversity, showcasing nature's ability to synthesize complex molecules.
  • Biological Significance: Compounds of similar structural classes may exhibit a variety of biological activities, including antimicrobial, anti-inflammatory, or anticancer properties, making this class of compounds valuable in pharmaceutical research.
  • Chirality: With multiple chiral centers (indicated by the R and S configurations), the enantiomers of this compound may have different pharmacological effects, emphasizing the importance of stereochemistry in drug design and activity.
  • Optimizing Synthesis: The synthetic pathways leading to such complex structures illustrate both challenges and advancements in organic synthesis, with chemists continuously exploring new methods to create and optimize these molecules efficiently.
  • Potential Applications: Owing to its complex configuration, this compound may serve as a lead structure, guiding the development of new synthetic methodologies or natural product synthesis in the search for novel therapeutic agents.

In summary, the exploration of compounds like this one not only enriches our understanding of organic chemistry but also opens doors to potential therapeutic discoveries that could significantly impact healthcare. As stated by renowned chemist Linus Pauling, "The best way to have a good idea is to have lots of ideas," highlighting the pursuit of knowledge within chemical research.