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Trospium chloride

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Identification
Molecular formula
C25H30ClNO3
CAS number
10405-02-4
IUPAC name
dimethyl-[2-[2-(1-naphthylmethyl)-3-tetrahydrofuran-2-yl-propanoyl]oxyethyl]ammonium;2-hydroxy-2-oxo-acetate
State
State

Trospium chloride is typically found in a solid state at room temperature, particularly as a powder used for formulating drugs.

Melting point (Celsius)
211.00
Melting point (Kelvin)
484.15
Boiling point (Celsius)
160.00
Boiling point (Kelvin)
433.15
General information
Molecular weight
427.98g/mol
Molar mass
427.9840g/mol
Density
1.1442g/cm3
Appearence

Trospium chloride appears as a white or almost white crystalline powder that is odorless. It's highly soluble in water and has a slight bitter taste. It is generally presented as an oral formulation as well as a solution for injection.

Comment on solubility

Solubility of Dimethyl-[2-[2-(1-naphthylmethyl)-3-tetrahydrofuran-2-yl-propanoyl]oxyethyl]ammonium; 2-hydroxy-2-oxo-acetate

This compound exhibits interesting solubility characteristics, which can greatly affect its application in various chemical and pharmaceutical fields. The solubility is determined by several factors that interplay in unique ways:

  • Polarity: The presence of the ammonium group contributes to an increased polarity, suggesting that the compound may have good solubility in polar solvents such as water.
  • Hydrophobic Interactions: The naphthylmethyl moiety introduces hydrophobic characteristics, indicating that the compound could also dissolve well in nonpolar organic solvents.
  • Functional Groups: The presence of hydroxyl and ketone functional groups in the 2-hydroxy-2-oxo-acetate moiety can facilitate hydrogen bonding, enhancing solubility in aqueous solutions.

In practice, solubility can be described through the following observations:

  • This compound is likely to be moderately soluble in water due to its ionic nature from the ammonium group.
  • It may show enhanced solubility in a mixture of polar and nonpolar solvents, offering versatility in its uses.
  • Temperature and pH can also significantly influence its solubility profile.

Overall, understanding the solubility of this compound is crucial for its effective utilization in various applications, and its behavior in different solvents provides key insights for chemists working with similar structures.

Interesting facts

Interesting Facts about Dimethyl-[2-[2-(1-naphthylmethyl)-3-tetrahydrofuran-2-yl-propanoyl]oxyethyl]ammonium; 2-hydroxy-2-oxo-acetate

This compound represents a fascinating intersection of organic chemistry and pharmacology, showcasing the potential of combining complex molecular structures with functional groups. Here are some noteworthy aspects:

  • Complex Structure: This compound features a diverse molecular architecture, incorporating a tetrahydrofuran ring, which is renowned for its presence in various naturally occurring compounds, and an naphthylmethyl group, known for its stability and effectiveness in drug design.
  • Ammonium Ion: The presence of a dimethylammonium ion indicates that this compound may exhibit interesting properties such as ionic interactions, which can be critical for biological activity and solubility in physiological environments.
  • Potential Pharmacological Applications: Given its structural components, this compound could be investigated for its biological activity, potentially showcasing effects on neurotransmitter systems or enzymatic processes, making it a candidate for therapeutic research.
  • Importance of Esters: The inclusion of an ester functional group (2-hydroxy-2-oxo-acetate) could enhance the compound's reactivity and suitability for biochemical interactions, which are crucial for drug efficacy and metabolic pathways.

In conclusion, the complexity and potential utility of this compound make it a compelling subject for further research. As highlighted by renowned chemists, “The beauty of chemistry lies in the intricate tapestry of molecules and their interactions.” Thus, exploring this compound's properties might unlock new pathways in both synthetic and medicinal chemistry.

Synonyms
3209-86-7
alpha-(1-Naphthylmethyl)tetrahydro-2-furanpropionic acid 2-(dimethylamino)ethyl ester oxalate
2-Furanpropionic acid, tetrahydro-alpha-(1-naphthylmethyl)-, 2-(dimethylamino)ethyl ester, oxalate (1:1)
N,N-Dimethyl-2-((3-(naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)methyl)propanoyl)oxy)ethanaminium carboxyformate