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Bromhexine hydrochloride

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Identification
Molecular formula
C14H21ClN2
CAS number
611-75-6
IUPAC name
dimethyl-[2-[2-[2-(1-piperidyl)ethyl]benzimidazol-1-yl]propyl]ammonium;chloride
State
State
At room temperature, it is in a solid state, typically found in its crystalline powder form, and is stable under normal conditions of use and storage.
Melting point (Celsius)
243.00
Melting point (Kelvin)
516.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
412.10g/mol
Molar mass
412.0950g/mol
Density
1.0720g/cm3
Appearence

The compound appears as a nearly white crystalline powder. It is known for its crystalline structure that can reflect light, giving it a powdery yet slightly glossy appearance under direct lighting.

Comment on solubility

Solubility of Dimethyl-[2-[2-[2-(1-piperidyl)ethyl]benzimidazol-1-yl]propyl]ammonium; Chloride

The compound Dimethyl-[2-[2-[2-(1-piperidyl)ethyl]benzimidazol-1-yl]propyl]ammonium chloride is an interesting example of a quaternary ammonium salt. The solubility characteristics of this compound can be described as follows:

  • Solvent Compatibility: Generally, quaternary ammonium compounds like this are known to be soluble in polar solvents such as water and methanol due to their ionic nature.
  • Ionic Interaction: The presence of the chloride ion enhances its solubility by facilitating ion-dipole interactions with water molecules.
  • Hydrophobic Regions: Given the aromatic and piperidine groups in its structure, there might be competing hydrophobic interactions, which could impact its solubility in less polar solvents.

In summary, while Dimethyl-[2-[2-[2-(1-piperidyl)ethyl]benzimidazol-1-yl]propyl]ammonium chloride is likely to exhibit good solubility in polar solvents, it may present variable solubility in non-polar solvents due to its complex molecular framework. Therefore, an appropriate solvent must be chosen based on the desired application and the conditions of use.

Interesting facts

Interesting Facts about Dimethyl-[2-[2-[2-(1-piperidyl)ethyl]benzimidazol-1-yl]propyl]ammonium; Chloride

Dimethyl-[2-[2-[2-(1-piperidyl)ethyl]benzimidazol-1-yl]propyl]ammonium; chloride is a fascinating compound that showcases the intersection of organic chemistry and pharmacology. Here are some intriguing highlights about this compound:

  • Unique Structure: This compound features a complex arrangement, including a piperidine ring and a benzimidazole moiety, which contribute to its distinctive properties and potential biological activities.
  • Biological Relevance: Compounds containing a piperidine moiety are often studied for their roles in medicinal chemistry, particularly as they exhibit a range of pharmacological effects, such as acting as neurotransmitter inhibitors.
  • Quaternary Ammonium Compound: Being a quaternary ammonium compound, it has applications in various fields, including surfactants and as a biocide due to its ability to disrupt membrane integrity in microbes.
  • Research Opportunities: Ongoing research explores the potential of related compounds for treating ailments such as anxiety and cognitive disorders, highlighting its significance in pharmaceuticals.
  • Customizable Synthesis: The synthesis of this compound allows for modifications that can create various analogs, paving the way for discovering new therapeutic agents.

In the words of a fellow chemist, “The beauty of organic compounds lies not just in their structure, but in their potential to change lives.” This compound is a perfect embodiment of that sentiment, underscoring the delicate balance between structure and function in the world of chemistry.


Furthermore, its role as a chloride salt emphasizes the importance of ionizable groups in modulating the solubility and bioavailability of drugs. As research progresses, the insights gained from studying dimethyl-[2-[2-[2-(1-piperidyl)ethyl]benzimidazol-1-yl]propyl]ammonium; chloride may lead to breakthroughs in targeted therapy, highlighting the ongoing journey of chemical exploration and innovation.

Synonyms
Benzimidazole, 1-(2-(dimethylamino)-1-methylethyl)-2-(2-piperidino)ethyl-, hydrochloride
1-(2-(Dimethylamino)-1-methylethyl)-2-(2-piperidino)ethylbenzimidazole hydrochloride
19809-24-6
RefChem:325811