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Quazepam

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Identification
Molecular formula
C19H19Cl2F3N2
CAS number
36735-22-5
IUPAC name
dimethyl-[2-[2-oxo-5-phenyl-7-(trifluoromethyl)-3H-1,4-benzodiazepin-4-ium-1-yl]ethyl]ammonium;dichloride
State
State

Quazepam is typically solid at room temperature. It is available in a stable crystalline form that is suitable for pharmaceutical applications.

Melting point (Celsius)
235.00
Melting point (Kelvin)
508.15
Boiling point (Celsius)
299.80
Boiling point (Kelvin)
572.95
General information
Molecular weight
460.28g/mol
Molar mass
460.2840g/mol
Density
1.5800g/cm3
Appearence

Quazepam dichloride typically appears as a white to off-white crystalline powder. It is often presented in a hygroscopic form, especially when formulated as a salt, causing it to absorb moisture from the environment.

Comment on solubility

Solubility of Dimethyl-[2-[2-oxo-5-phenyl-7-(trifluoromethyl)-3H-1,4-benzodiazepin-4-ium-1-yl]ethyl]ammonium;dichloride

The solubility of Dimethyl-[2-[2-oxo-5-phenyl-7-(trifluoromethyl)-3H-1,4-benzodiazepin-4-ium-1-yl]ethyl]ammonium;dichloride is influenced by several factors, given its complex structure. Here are some key points regarding its solubility:

  • Polar Nature: The compound is likely polar due to the presence of the quaternary ammonium salt, which typically increases solubility in polar solvents such as water.
  • Hydrophilic and Hydrophobic Balance: The multiple functional groups present, particularly the benzodiazepin-4-ium moiety and the trifluoromethyl group, contribute to its solubility characteristics. While the ammonium group is hydrophilic, the trifluoromethyl group adds a hydrophobic character, potentially affecting overall solubility.
  • Solvent Dependence: Solubility may vary significantly depending on the solvent used. It is expected to dissolve more readily in aqueous solutions rather than in non-polar solvents.

In conclusion, the solubility of this compound is likely good in polar solvents but may be limited in non-polar environments. The functional groups imply a delicate balance between hydrophilic and hydrophobic interactions, necessitating careful consideration of the solvent choice in applications. As a general note, *“Understanding solubility is key to predicting the behavior of compounds in various environments.”*

Interesting facts

Interesting Facts about Dimethyl-[2-[2-oxo-5-phenyl-7-(trifluoromethyl)-3H-1,4-benzodiazepin-4-ium-1-yl]ethyl]ammonium;dichloride

This compound belongs to a class of chemicals known for their unique structural properties and potential applications in medicinal chemistry. Here are some intriguing insights into this fascinating compound:

  • Benzodiazepine Derivative: The backbone of this compound features a benzodiazepine structure, which is renowned for its ability to interact with the central nervous system.
  • Trifluoromethyl Group: The trifluoromethyl (-CF3) moiety is a significant substituent in drug design, as it enhances lipophilicity and can improve metabolic stability.
  • Pharmacological Potential: Compounds with this type of structure may exhibit anxiolytic (anti-anxiety) and sedative properties, which are vital in the field of psychopharmacology.
  • Ion Exchange: The dichloride component indicates the presence of chloride ions, which can facilitate ion exchange processes and play a role in biological membrane permeability.
  • Research Interest: Scientists are continuously exploring the therapeutic properties of benzodiazepine derivatives, making this compound a subject of ongoing research.

In summary, dimethyl-[2-[2-oxo-5-phenyl-7-(trifluoromethyl)-3H-1,4-benzodiazepin-4-ium-1-yl]ethyl]ammonium; dichloride offers a window into the complexities of chemical design and its implications in medicine. As research progresses, compounds like this one may unlock new pathways in treatment options, particularly in neuropharmacology.

Synonyms
1959-19-9
2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-1-(2-(dimethylamino)ethyl)-5-phenyl-7-(trifluoromethyl)-, dihydrochloride