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Dimethyl 2-oxoglutarate

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Identification
Molecular formula
C7H10O5
CAS number
338-69-2
IUPAC name
dimethyl 2-oxopentanedioate
State
State

At room temperature, dimethyl 2-oxoglutarate is in a liquid state.

Melting point (Celsius)
-19.00
Melting point (Kelvin)
254.00
Boiling point (Celsius)
218.00
Boiling point (Kelvin)
491.00
General information
Molecular weight
174.15g/mol
Molar mass
174.1530g/mol
Density
1.1950g/cm3
Appearence

Dimethyl 2-oxoglutarate is a colorless liquid with a mild, pleasant odor. It is often stored and handled as a liquid form due to its low melting point.

Comment on solubility

Solubility of Dimethyl 2-Oxopentanedioate

Dimethyl 2-oxopentanedioate, commonly known as a type of diester, exhibits interesting solubility characteristics that are important for its applications in various fields. Here are some key points regarding its solubility:

  • Solvent Compatibility: Dimethyl 2-oxopentanedioate is generally soluble in polar organic solvents such as methanol, ethanol, and acetone, making it useful in organic synthesis and as a solvent for reactions.
  • Water Solubility: The solubility in water is limited due to its hydrophobic alkyl groups, which can hinder interaction with water molecules.
  • Temperature Effects: Solubility can vary significantly with temperature. Increased temperatures often enhance the solubility of organic compounds, allowing for greater dissolution in solvents.
  • pH Influence: The presence of acidic or basic media may also affect the solubility of dimethyl 2-oxopentanedioate, potentially leading to ionization of the carboxylate groups under different pH conditions.

As a notable example, a researcher once remarked, “The solubility of compounds in various media can reveal much about their chemical behavior.” Therefore, understanding the solubility profile of dimethyl 2-oxopentanedioate is essential for optimizing its usage in chemical synthesis and material science.

Interesting facts

Interesting Facts About Dimethyl 2-Oxopentanedioate

Dimethyl 2-oxopentanedioate, also known as dimethyl ethylmalonate, is an intriguing compound that belongs to the class of esters. Here are some engaging facts about this chemical:

  • Versatile Building Block: Dimethyl 2-oxopentanedioate serves as an important intermediate in organic synthesis, showcasing its utility in creating more complex molecules.
  • Synthesis and Reactions: This compound can be synthesized through various methods, including the condensation of dimethyl malonate with α-keto acids. It participates in a range of reactions such as Michael addition and condensation, making it a versatile compound in the laboratory.
  • Role in Medicinal Chemistry: The compound is significant in medicinal chemistry for the development of pharmaceuticals. It acts as a precursor in the synthesis of various bioactive molecules, highlighting its relevance in drug discovery.
  • Flavoring Agent Potential: Due to its unique structure, dimethyl 2-oxopentanedioate may also have applications in flavoring and fragrance industries, contributing to the development of new compounds with appealing scents or tastes.
  • Environmental Considerations: As with many organic compounds, studying dimethyl 2-oxopentanedioate also raises questions about its environmental impact and sustainability in manufacturing processes, making it an important subject for further research.

In summary, dimethyl 2-oxopentanedioate is more than just a simple ester; it is a powerful tool in synthetic chemistry with diverse applications, from pharmaceuticals to potential flavoring agents. Understanding its properties and reactivity can lead to exciting advancements in various fields.

Synonyms
Dimethyl 2-oxoglutarate
1,5-dimethyl 2-oxopentanedioate
965-192-9
13192-04-6
Dimethyl 2-oxopentanedioate
Dimethyl 2-ketoglutaconate
2-Ketoglutaric Acid Dimethyl Ester
Dimethyl 2-Ketoglutarate
dimethyl alpha-ketoglutarate
Pentanedioic acid, 2-oxo-, 1,5-dimethyl ester
Pentanedioic acid, 2-oxo-, dimethyl ester
2-OXOPENTANEDIOIC ACID, DIMETHYL ETHER
MFCD00048052
Dimethyl2-oxoglutarate
Dimethyl-alpha-ketoglutarate
2-Oxoglutaric Acid Dimethyl Ester
Glutaric acid, 2-oxo-, dimethyl ester
SCHEMBL9543
Dimethyl 2-oxopentanedioate #
Dimethyl-.alpha.-ketoglutarate
Dimethyl 2-oxoglutarate, 96%
CHEMBL4877741
DTXSID10157251
CHEBI:173796
BCP24128
NSC783840
AKOS015851605
FD22239
NSC-783840
SB32822
AS-47656
HY-44134
SY004319
DB-007425
CS-0103277
K0013
F14954
EN300-1661000
Q65707091
a-Ketoglutaric acid dimethyl ester;Dimethyl 2-oxopentanedioate;2-Oxo-pentanedioic acid 1,5-dimethyl ester