Nifedipine | Solubility of Things

Identification

Molecular formula

C₁₇H₁₈N₂O₆

CAS number

21829-25-4

IUPAC name

dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

State

At room temperature, Nifedipine is typically a solid. It exists as a crystalline substance that does not easily vaporize and requires solvation in appropriate organic solvents for practical use in various applications. Its solid state contributes to its stability under normal conditions.

Melting point (Celsius)

173.00

Melting point (Kelvin)

446.15

Boiling point (Celsius)

707.30

Boiling point (Kelvin)

980.45

General information

Molecular weight

346.34g/mol

Molar mass

346.3350g/mol

Density

1.4674g/cm³

Appearence

Nifedipine appears as a yellow crystalline powder that is almost insoluble in water, but soluble in organic solvents such as ethanol and acetone. It can also appear as colorless crystals when highly pure.

Comment on solubility

Solubility of Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (C₁₇H₁₈N₂O₆) exhibits intriguing solubility characteristics due to its complex chemical structure. Understanding its solubility is crucial for various applications in medicinal chemistry and pharmaceuticals. Here are some key points to consider:

Polarity: The presence of multiple functional groups, including nitro and carboxylate moieties, contributes to the overall polarity of the molecule, enhancing its ability to interact with solvents.
Solvent Compatibility: The compound is likely to be soluble in polar solvents such as water and methanol, while demonstrating lower solubility in non-polar solvents.
Temperature Influence: As with many organic compounds, solubility may increase with temperature, facilitating dissolution.
pH Sensitivity: The solubility of this compound can also be influenced by pH, particularly due to the carboxylate groups, which can ionize in more basic conditions, enhancing solubility.
Application Considerations: A thorough understanding of its solubility is essential for optimizing its use in biological assays and drug formulations.

In conclusion, the solubility of C₁₇H₁₈N₂O₆ is largely contingent on its molecular structure and the specific conditions of dissolution. Experimentation and environmental factors play pivotal roles in determining how well this compound will integrate into different solvents.

Interesting facts

Exploring Dimethyl 2,6-Dimethyl-4-(2-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate

Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate is a fascinating compound that belongs to the class of dihydropyridines, which are known for their vital roles in medicinal chemistry. Here are some intriguing aspects of this compound:

Pharmacological Significance: Dihydropyridine derivatives are widely studied for their potential as calcium channel blockers and antihypertensive agents. This compound's unique structure allows it to interact with biological systems in potentially beneficial ways.
Electron-Withdrawing Nitrophenyl Group: The presence of the nitrophenyl group significantly affects the electronic properties of the molecule. This group can enhance the compound’s ability to participate in various chemical reactions, influencing its activity and reactivity.
Versatile Synthesis: One of the exciting aspects of dicarboxylate derivatives is that they can be synthesized using various methods, often leading to compounds with diverse biological activities. This versatility makes it a compound of choice for synthetic chemists.
Application in Organic Synthesis: The compound serves as a valuable intermediate in organic synthesis. The functional groups present can be utilized for further modifications, allowing for the creation of a range of new derivatives.
Potential Antioxidant Properties: Some studies indicate that compounds like this may exhibit antioxidant properties, which are important for combating oxidative stress in biological systems.

As a student of chemistry or a researcher, understanding compounds like dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate opens up a world of exploration into their vast potential applications in both pharmacology and synthetic chemistry. The interplay of structure and function in such molecules is truly a captivating topic.

Synonyms

nifedipine

21829-25-4

Adalat

Procardia

Procardia XL

Adalat CC

Fenihidine

Citilat

Cordipin

Corinfar

Oxcord

Coracten

Fenihidin

dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Afeditab CR

Bay-a-1040

Nifediac

Nifedipino

Nifedipinum

Adalate

Adapine

Nifedical

Afeditab

Cordafen

Cordaflex

Corynphar

Hexadilat

Introcar

Kordafen

Nifecard

Nifedipres

Tibricol

Anifed

Glopir

Nifecor

Nifedin

Nifelat

Pidilat

Sepamit

Zenusin

Orix

Adipine XL

1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl ester

Adalat LA

BAY A 1040

Nifedical XL

MFCD00057326

Nifedipine slow release

CCRIS 6074

CHEBI:7565

Nifedipinum [INN-Latin]

Nifedipino [INN-Spanish]

I9ZF7L6G2L

NSC-757242

3,5-dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

DTXSID2025715

EINECS 244-598-3

CHEMBL193

UNII-I9ZF7L6G2L

BRN 0497773

Dimethyl 1,4-dihydro-2,6-dimethyl-4-(2'-nitrophenyl)-3,5-pyridinedicarboxylate

Dimethyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate

MLS000028521

DTXCID205715

BAY-a 1040

HSDB 7775

4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine

Dimethyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate

NSC 757242

NCGC00015748-11

Chronadalate

Dignokonstant

Niphedipine

Adapress

Aldipin

Alfadal

Angipec

Aprical

Bonacid

Calcibloc

Calcigard

Calcilat

Cardifen

Cardilat

Cardionorm

Cordalat

Cordicant

Cordilan

Corotrend

Dilafed

Dipinkor

Duranifin

Ecodipi

Ecodipin

Fenamon

Hadipin

Macorel

Megalat

Myogard

Nifedicor

Nifelan

Nificard

SMR000058291

Alonix

Anpine

Camont

Fedcor

Depin

Alat

Adalat Retard

CAS-21829-25-4

Fedcor Retard

Adalat Crono

Chronadalate LP

Nifedipinum (INN-Latin)

Adalat Oros

Ecodipin E

Apo-Nifed

Nifedipino (INN-Spanish)

Nifensar XL

Alonix S

Fenamon SR

Adalat CR

Adalat FT

Adalat LP

Adalat PA

NIFEDIPINE (MART.)

NIFEDIPINE [MART.]

Adalat GITS

4-(2'-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsaeuredimethylester

NIFEDIPINE (USP-RS)

NIFEDIPINE [USP-RS]

Adalat 5

5-22-04-00268 (Beilstein Handbook Reference)

Adalat 10

Adalat 20

Adalat GITS 30

NIFEDIPINE (EP MONOGRAPH)

NIFEDIPINE (USP IMPURITY)

NIFEDIPINE [EP MONOGRAPH]

NIFEDIPINE [USP IMPURITY]

Alpha-Nifedipine Retard

Emaberin

NIFEDIPINE (USP MONOGRAPH)

NIFEDIPINE [USP MONOGRAPH]

Dilcor

Aprical long

Slofedipine XL

Fortipine LA

Tensipine MR

2,6-Dimethyl-3,5-dicarbomethoxy-4-(2-nitrophenyl)-1,4-dihydropyridine

4-(2-Nitrophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine

Adalate LP

Adalat XL

Nifedipine (USAN:USP:INN:BAN:JAN)

Nifedipine [USAN:USP:INN:BAN:JAN]

Dimethyl 4-(2-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Procardia (TN)

193689-82-6

Adalat (TN)

Afeditab CR (TN)

SR-01000075332

nifedipina

BAYa1040

Aldipine

NifedicalXL

NifedipineER

ProcardiaXL

AfeditabCR

NifedicalXLXL

Nifediac Cc

Nifedipine,(S)

BAY 1040

KB-1712P

Prestwick_357

Nifedipine (Adalat)

Nifedipine (Standard)

Spectrum_000979

Tocris-1075

NIFEDIPINE [MI]

NIFEDIPINE [INN]

NIFEDIPINE [JAN]

Opera_ID_1816

Prestwick0_000063

Prestwick1_000063

Prestwick2_000063

Prestwick3_000063

Spectrum2_001058

Spectrum3_000516

Spectrum4_000074

Spectrum5_001278

Lopac-N-7634

NIFEDIPINE [HSDB]

NIFEDIPINE [USAN]

NifedipineExtended Release

NIFEDIPINE [VANDF]

Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate

N 7634

cid_4485

SCHEMBL3968

NIFEDIPINE [WHO-DD]

NIFEDIPINE [WHO-IP]

BIDD:PXR0034

CBiol_001826

Lopac0_000819

Oprea1_788617

BSPBio_000245

BSPBio_001391

BSPBio_002071

KBioGR_000111

KBioGR_000627

KBioGR_002400

KBioSS_000111

KBioSS_001459

KBioSS_002405

MLS000758222

MLS001148146

MLS001401371

BIDD:GT0442

DivK1c_000313

SPECTRUM1500431

SPBio_001016

SPBio_002166

BPBio1_000271

GTPL2514

Nifedipine (JP17/USP/INN)

Nifedipine - Bio-X trade mark

NIFEDIPINE [ORANGE BOOK]

BCBcMAP01_000046

HMS500P15

HY-B0284R

KBio1_000313

KBio2_000111

KBio2_001459

KBio2_002400

KBio2_002679

KBio2_004027

KBio2_004968

KBio2_005247

KBio2_006595

KBio2_007536

KBio3_000221

KBio3_000222

KBio3_001571

KBio3_002879

C08CA05

TN 873R

cMAP_000042

NINDS_000313

Bio1_000112

Bio1_000601

Bio1_001090

Bio2_000111

Bio2_000591

HMS1361F13

HMS1568M07

HMS1791F13

HMS1920P19

HMS1989F13

HMS2051O03

HMS2089H11

HMS2091H20

HMS2095M07

HMS2233B22

HMS3262D19

HMS3267G06

HMS3393O03

HMS3412E17

HMS3651M19

HMS3676E17

HMS3712M07

HMS3748O21

Pharmakon1600-01500431

NIFEDIPINUM [WHO-IP LATIN]

BCP21147

HY-B0284

L-Type Calcium Channel Blocker III

Tox21_110212

Tox21_200304

Tox21_500819

BBL023163

BDBM50000778

BDBM50101817

CCG-40115

HB1228

NSC757242

NSC786036

s1808

STK735567

AKOS002942507

AKOS037515769

Nifedipine - CAS 21829-25-4

Nifedipine, >=98% (HPLC), powder

Tox21_110212_1

AC-8061

CCG-100758

DB01115

FN26213

KS-1456

LP00819

NC00008

NSC-786036

SDCCGSBI-0050796.P005

4-(2'-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsaeuredimethylester [German]

IDI1_000313

IDI1_033861

Bay-1040;Bay 1040;Bay1040

NCGC00015748-01

NCGC00015748-02

NCGC00015748-03

NCGC00015748-04

NCGC00015748-05

NCGC00015748-06

NCGC00015748-07

NCGC00015748-08

NCGC00015748-09

NCGC00015748-10

NCGC00015748-12

NCGC00015748-13

NCGC00015748-14

NCGC00015748-15

NCGC00015748-17

NCGC00015748-18

NCGC00015748-33

NCGC00021710-02

NCGC00024983-01

NCGC00024983-02

NCGC00024983-03

NCGC00024983-04

NCGC00024983-05

NCGC00024983-06

NCGC00024983-07

NCGC00024983-08

NCGC00091707-01

NCGC00091707-02

NCGC00091707-03

NCGC00257858-01

NCGC00261504-01

BN166183

CPD000058291

PD003075

PD033039

SY074220

SBI-0050796.P004

EU-0100819

N0528

NS00002967

SW219724-1

BIM-0050796.0001

C07266

D00437

EN300-120627

Q39111

SBI-0050796.0002

AB00052051-05

AB00052051_06

AB00052051_07

L001054

SR-01000075332-1

SR-01000075332-3

SR-01000075332-4

SR-01000075332-6

BRD-K96354014-001-01-3

BRD-K96354014-001-10-4

BRD-K96354014-001-14-6

BRD-K96354014-001-15-3

BRD-K96354014-001-17-9

BRD-K96354014-001-21-1

BRD-K96354014-001-27-8

Z90350374

F2173-0802

Nifedipine, British Pharmacopoeia (BP) Reference Standard

Nifedipine, European Pharmacopoeia (EP) Reference Standard

Nifedipine, United States Pharmacopeia (USP) Reference Standard

4-(2'-nitrophenyl)-2,6 dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridine

4-(2'-nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridine

Nifedipine, Pharmaceutical Secondary Standard; Certified Reference Material

1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylicaciddimethylester

2,6-dimethyl-4-(2nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-dimethyl ester

4-(2'-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsauredimethylester

Dimethyl (4-(2-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate)

Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate #

dimethyl 4-(o-nitrophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate

dimethyl2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester;Adalate;Aldipin

101539-70-2

2,6-DIMETHYL-4-(2-NITROPHENYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID DIMETHYL ESTER

244-598-3

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl ester (9CI)

3,5-PYRIDINEDICARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-4-(O-NITROPHENYL)-, DIMETHYL ESTER

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-, dimethyl ester (8CI)

915092-63-6