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Acriflavine

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Identification
Molecular formula
C27H33N6Cl2
CAS number
8063-24-9
IUPAC name
dimethyl-[3-[(1-nitroacridin-9-yl)ammonio]propyl]ammonium;dichloride
State
State

At room temperature, acriflavine typically exists in a solid state, usually as a crystalline or powder form. It is often prepared and distributed as a reconstitutable powder or liquid for various applications.

Melting point (Celsius)
258.00
Melting point (Kelvin)
531.15
Boiling point (Celsius)
400.00
Boiling point (Kelvin)
673.15
General information
Molecular weight
327.25g/mol
Molar mass
327.2450g/mol
Density
1.1000g/cm3
Appearence

Acriflavine is an orange or brown crystalline solid that is commonly encountered in the form of a hydrochloride salt. It exhibits a vivid, bright coloration and is often used as a fluorescent dye. The compound may appear as a powder or crystalline form and dissolves to give yellow solutions under certain conditions.

Comment on solubility

Solubility of Dimethyl-[3-[(1-nitroacridin-9-yl)ammonio]propyl]ammonium Dichloride

The solubility of dimethyl-[3-[(1-nitroacridin-9-yl)ammonio]propyl]ammonium dichloride presents several intriguing aspects:

  • Solvent Polarity: This compound's solubility is highly influenced by the polarity of the solvent. Typically, it can dissolve well in polar solvents due to its ionic nature.
  • Association with Chloride Ions: The presence of dichloride ions facilitates its dissolution in water and other polar solvents, which tend to stabilize the cationic form of the compound.
  • Temperature Dependence: Generally, the solubility of ionic compounds tends to increase with temperature, which could be beneficial in various applications.
  • Hydrophobic Interactions: Part of the molecule, arising from the acridine moiety, could exhibit hydrophobic characteristics, which might limit solubility in non-polar solvents.

In practical applications, understanding this solubility profile is vital for optimizing formulations, particularly in pharmaceutical contexts where the bioavailability of such compounds can be significantly affected by their dissolution behavior.

In summary, the solubility of dimethyl-[3-[(1-nitroacridin-9-yl)ammonio]propyl]ammonium dichloride is governed by a complex interplay of factors, making it essential to consider these parameters for effective use.

Interesting facts

Interesting Facts about Dimethyl-[3-[(1-Nitroacridin-9-yl)ammonio]propyl]ammonium Dichloride

This fascinating compound, known as Dimethyl-[3-[(1-nitroacridin-9-yl)ammonio]propyl]ammonium dichloride, belongs to a unique class of chemical structures that often play vital roles in medicinal chemistry and biological applications.

Unique Structural Features

  • Ammonium Group: The presence of the ammonium group in the structure provides interesting properties, as it can engage in hydrogen bonding, which is crucial for interaction with biological molecules.
  • Nitroacridine Moiety: The inclusion of a nitroacridine component suggests potential applications in cancer therapies, as acridine derivatives are known to exhibit antitumor activities.
  • Dimethylation: The dimethyl groups enhance solubility and biological activity, making this compound potentially useful in various pharmaceutical formulations.

Potential Applications

This compound is not just a chemical curiosity; it has potential implications in various fields:

  • Anticancer Research: Due to its structural resemblance to known chemotherapeutic agents, it may have significant anticancer properties that warrant further investigation.
  • Biological Studies: It can serve as a probe in studying cellular mechanisms, especially in cancer cells, assisting scientists in understanding drug effectiveness.
  • Developing Novel Therapeutics: The unique chemical properties could make it a candidate for designing new medicines targeting specific pathways in cancer treatment.

Research Opportunities

Research involving this compound could yield valuable insights. Areas of exploration might include:

  • Mechanisms of action against various types of cancer cells.
  • Synergistic effects when used in combination with other chemotherapeutic agents.
  • The development of drug delivery systems tailored to enhance efficacy and reduce side effects.

In conclusion, Dimethyl-[3-[(1-nitroacridin-9-yl)ammonio]propyl]ammonium dichloride represents a promising intersection of chemistry and pharmacology, emphasizing the need for continued exploration to fully harness its potential.

Synonyms
Ledakrin
Ledacrine
Nitracrine dihydrochloride
6514-85-8
dimethyl-[3-[(1-nitroacridin-9-yl)azaniumyl]propyl]azanium;dichloride
1,3-Propanediamine, N,N-dimethyl-N'-(1-nitro-9-acridinyl)-, dihydrochloride
Nitracrine HCl
T450D0Q71D
NSC 247561
UNII-T450D0Q71D
CCRIS 9297
1-Nitro-9-(3-dimethylaminopropylamino)-acridine dihydrochloride
SCHEMBL1652148
ACRIDINE, 9-((3-(DIMETHYLAMINO)PROPYL)AMINO)-1-NITRO-, DIHYDROCHLORIDE
1-NITRO-9-(DIMETHYLAMINOPROPYLAMINO)ACRIDINE DIHYDROCHLORIDE