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Clotrimazole

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Identification
Molecular formula
C22H17ClN2O
CAS number
23593-75-1
IUPAC name
dimethyl-[3-[5-nitro-2-[2-(1-piperidyl)ethyl]benzimidazol-1-yl]propyl]ammonium;chloride
State
State
At room temperature, Clotrimazole is typically found as a solid. It is an antifungal medication used to treat infections caused by fungus.
Melting point (Celsius)
142.00
Melting point (Kelvin)
415.15
Boiling point (Celsius)
436.20
Boiling point (Kelvin)
709.35
General information
Molecular weight
274.19g/mol
Molar mass
274.1930g/mol
Density
1.2490g/cm3
Appearence

Clotrimazole is a white or almost white crystalline powder. It may also be odorless or have a slightly characteristic odor. The compound is primarily used in medical applications, hence its pharmaceutical-grade appearance is common.

Comment on solubility

Solubility of Dimethyl-[3-[5-nitro-2-[2-(1-piperidyl)ethyl]benzimidazol-1-yl]propyl]ammonium Chloride

The solubility of dimethyl-[3-[5-nitro-2-[2-(1-piperidyl)ethyl]benzimidazol-1-yl]propyl]ammonium chloride can be influenced by various factors due to its complex structure. Here are key points to consider:

  • Aqueous Solubility: Generally, ammonium salts such as this compound tend to be soluble in water, which is attributed to their ionic nature and ability to interact with water molecules.
  • Effect of Temperature: Like many chemical compounds, its solubility may increase with temperature. This phenomenon is particularly relevant in aqueous solutions.
  • Organic Solvents: Some data may suggest that the compound demonstrates variable solubility in organic solvents. The presence of the piperidyl group and nitro substituent might further influence its solubility profile.
  • pH Dependence: Solubility can also be pH-dependent. The presence of protonable sites in the compound may enhance solubility in acidic conditions.

In summary, while dimethyl-[3-[5-nitro-2-[2-(1-piperidyl)ethyl]benzimidazol-1-yl]propyl]ammonium chloride is expected to exhibit good solubility in water and potentially in certain organic solvents, detailed solubility data under varying conditions is essential for practical applications. Understanding the context of its use will provide better insight into optimizing its solubility characteristics.

Interesting facts

Interesting Facts About Dimethyl-[3-[5-Nitro-2-[2-(1-Piperidyl)ethyl]benzimidazol-1-yl]propyl]ammonium; Chloride

This compound exhibits fascinating characteristics that make it stand out in the field of medicinal chemistry. Here are some key points to consider:

  • Pharmacological Relevance: The presence of a benzimidazole ring is particularly noteworthy, as compounds containing this structure are often investigated for their antiviral and anticancer properties.
  • Functional Groups: The inclusion of a nitro group on the aromatic system can enhance the compound's biological activity by serving as a potential pharmacophore, highlighting the importance of functional group manipulation in drug design.
  • Piperidine Incorporation: The piperidyl group is known for its ability to increase the solubility and bioavailability of drugs, making this compound potentially effective in pharmaceutical applications.
  • Structure-Activity Relationship (SAR): Understanding the relationship between the structure of this compound and its biological activity offers valuable insights for further development. The structural complexity can lead to a range of activities, sparking interest in collaborative studies with biochemists.
  • Transport Mechanisms: Chloride ions play a crucial role in various physiological processes. As a quaternary ammonium compound, it may interact with various cell membrane systems, offering additional avenues for research into drug delivery methods.

In conclusion, dimethyl-[3-[5-nitro-2-[2-(1-piperidyl)ethyl]benzimidazol-1-yl]propyl]ammonium; chloride serves as an excellent example of how structural complexity can lead to diverse applications in therapeutic development. The exploration of this compound may further our understanding of its mechanisms and actions, paving the way for innovative medical therapies.

Synonyms
Benzimidazole, 1-(3-(dimethylamino)propyl)-5-nitro-2-(2-piperidinoethyl)-, hydrochloride
1-(3-(Dimethylamino)propyl)-5-nitro-2-(2-(piperidino)ethyl)benzimidazole hydrochloride
19809-17-7
RefChem:325822