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Midazolam

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Identification
Molecular formula
C18H13ClFN3
CAS number
59467-70-8
IUPAC name
dimethyl-[3-(7-nitro-2-oxo-5-phenyl-3H-1,4-benzodiazepin-1-yl)propyl]ammonium;chloride
State
State

At room temperature, midazolam is found in a solid state. Generally provided in its hydrochloride salt form for pharmaceutical purposes.

Melting point (Celsius)
98.00
Melting point (Kelvin)
371.15
Boiling point (Celsius)
239.80
Boiling point (Kelvin)
512.90
General information
Molecular weight
362.88g/mol
Molar mass
362.8780g/mol
Density
1.3000g/cm3
Appearence

Midazolam is a white to off-white crystalline solid.

Comment on solubility

Solubility of Dimethyl-[3-(7-nitro-2-oxo-5-phenyl-3H-1,4-benzodiazepin-1-yl)propyl]ammonium Chloride

The solubility of the compound dimethyl-[3-(7-nitro-2-oxo-5-phenyl-3H-1,4-benzodiazepin-1-yl)propyl]ammonium chloride is an intriguing subject due to its unique structural characteristics. Here are some key points regarding its solubility:

  • Nature of the compound: Being a quaternary ammonium salt, it tends to exhibit improved solubility in polar solvents like water.
  • Ionization: The chloride ion contributes to the overall solubility, making the compound more soluble than some of its neutral counterparts.
  • Temperature dependence: As with many salts, the solubility may increase with temperature, showcasing the typical solubility trend where higher temperatures allow for greater solute dissolution.
  • pH Influence: The solubility could also be affected by the pH of the solution, as every protonation and deprotonation can alter interactions among the molecules.

Generally, it is observed that compounds with such complex structures may have varied solubility profiles, influenced by both their ionic nature and the specific environmental conditions. As a result, while the solubility of dimethyl-[3-(7-nitro-2-oxo-5-phenyl-3H-1,4-benzodiazepin-1-yl)propyl]ammonium chloride can be expected to be relatively high in aqueous solutions, detailed experimental data is always recommended for precise solubility metrics.

Interesting facts

Interesting Facts about Dimethyl-[3-(7-nitro-2-oxo-5-phenyl-3H-1,4-benzodiazepin-1-yl)propyl]ammonium;chloride

This compound represents a fascinating area of study in medicinal chemistry, particularly due to its connections to the benzodiazepine class, known for their therapeutic effects and potential in treating various neurological disorders. Here are some engaging insights:

  • Benzodiazepine Moiety: The compound features a benzodiazepine structure, which is integral to a significant number of medications prescribed for anxiety, insomnia, and seizures.
  • Nitro Group: The presence of a nitro group (–NO2) enhances the pharmacological properties of the compound, improving its efficacy and selectivity in targeting specific receptors in the brain.
  • Dimethylamine Functional Group: The dimethylamine component can potentially enhance the compound’s solubility and bioavailability, making it more effective when administered.
  • Structure-Activity Relationships (SAR): Scientists study the structure-activity relationships of such compounds extensively. This 'structure' impacts how the compound interacts with biological systems and can lead to modifications that improve therapeutic profiles.
  • Potential Applications: Due to its unique structure, this compound could be explored for novel therapeutic applications, particularly in the realm of psychoactive drugs, targeting various aspects of central nervous system disorders.

As research progresses, compounds like this one might reveal new pathways in drug development and lead to innovative solutions for mental health treatments. The exploration of their mechanisms, efficacy, and safety profiles is vital in advancing therapeutic strategies in this increasingly important field.

Synonyms
4219-01-6
2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-1-(3-(dimethylamino)propyl)-7-nitro-5-phenyl-, monohydrochloride
1-(3-(Dimethylamino)propyl)-1,3-dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one HCl