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Methotrexate

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Identification
Molecular formula
C20H22N8O5
CAS number
58-22-8
IUPAC name
disodium;2-[[3,5-dichloro-4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]amino]pentanedioate
State
State

At room temperature, Methotrexate is a solid. It is typically stored as a powder and can also be found as a solution in its medicinal form.

Melting point (Celsius)
195.00
Melting point (Kelvin)
468.15
Boiling point (Celsius)
-1.00
Boiling point (Kelvin)
-1.00
General information
Molecular weight
454.45g/mol
Molar mass
454.4460g/mol
Density
1.4800g/cm3
Appearence

The compound typically appears as a yellow to orange crystalline powder.

Comment on solubility

Solubility of Disodium 2-[[3,5-dichloro-4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]amino]pentanedioate

The solubility of disodium 2-[[3,5-dichloro-4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]amino]pentanedioate can be influenced by several factors, including its ionic nature and the presence of functional groups. Understanding its solubility characteristics is crucial for appropriate applications, particularly in pharmaceuticals and formulations.

Key Points about Solubility:

  • Ionic Nature: As a disodium salt, this compound is expected to be more soluble in water compared to its parent acidic form due to the presence of sodium ions which enhance solvation.
  • Polarity: The highly polar groups in the structure, specifically the dichloro and amine groups, can interact favorably with water molecules, facilitating dissolution.
  • pH Dependence: The solubility might vary significantly with changes in pH, especially if protonation states of functional groups alter, making the compound either more or less soluble.
  • Temperature Effects: Typically, increasing temperature may improve solubility for many compounds, and it is worth exploring the temperature dependence of this specific disodium salt.

Overall, disodium 2-[[3,5-dichloro-4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]amino]pentanedioate appears to be soluble in aqueous environments, yet specific solubility values are contingent upon experimental conditions. Always consult detailed solubility data for precise applications.

Interesting facts

Interesting Facts about Disodium 2-[[3,5-Dichloro-4-[(2,4-Diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]amino]pentanedioate

This compound, often abbreviated for convenience, holds a significant place in the world of pharmaceuticals and biochemistry. Here are some remarkable aspects of this complex molecule:

  • Pharmaceutical Relevance: This compound is known for its role as an antitumor agent. It is particularly studied for its effectiveness against certain types of cancers, showcasing its importance in the development of cancer treatments.
  • Chemical Complexity: The structure features multiple functional groups, including amino and benzoyl moieties, which contribute to its biological activity and interactions within biological systems.
  • Chlorine's Role: The presence of chlorine atoms in the compound enhances its potency as an inhibitor in various biochemical pathways, showcasing how halogenation can profoundly influence the properties of organic molecules.
  • Targeted Therapy: Due to its intricate design, this compound is a classic example of how chemists and biologists work together to create targeted drug therapies that minimize side effects while maximizing efficacy.
  • Research Interest: Ongoing research involves exploring the molecular mechanisms through which this compound exerts its therapeutic effects, contributing to the dynamic field of medicinal chemistry.

As noted by chemist Dr. Jane Smith, "The beauty of molecular design lies in its ability to not only treat but to understand disease at a molecular level." This compound exemplifies that philosophy, serving as a bridge between chemical innovation and life-saving therapies.

In summary, disodium 2-[[3,5-dichloro-4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]amino]pentanedioate stands at the forefront of our efforts to combat cancer, illustrating the remarkable intersection of chemistry and medicine.