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Methotrexate

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Identification
Molecular formula
C20H22N8O5
CAS number
59-05-2
IUPAC name
disodium;2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]amino]pentanedioate
State
State

At room temperature, methotrexate is a solid and is typically handled in powder form. Its low solubility in water and alcohol means that special care must be taken to ensure it is adequately dissolved for use in medical applications.

Melting point (Celsius)
195.00
Melting point (Kelvin)
468.00
Boiling point (Celsius)
745.00
Boiling point (Kelvin)
1 018.00
General information
Molecular weight
454.45g/mol
Molar mass
454.4450g/mol
Density
1.4370g/cm3
Appearence

Methotrexate is a pale yellow to yellow crystalline powder. It is practically insoluble in water and only slightly soluble in alcohol, which makes it necessary to use specific solvents or pharmaceutical formulations to dissolve it for therapeutic uses.

Comment on solubility

Solubility of Disodium 2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]amino]pentanedioate

The solubility of disodium 2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]amino]pentanedioate is an important consideration for its application in various fields. This compound is soluble in several solvents, primarily due to its ionic nature, which significantly influences its solvation behavior. Below are some key points regarding its solubility:

  • Water Solubility: As a disodium salt, it is generally highly soluble in water, allowing for easy dissolution and utility in biological systems.
  • Influence of pH: The solubility can vary with changes in pH, which can affect the ionization state of the compound, enhancing or diminishing its solubility.
  • Organic Solvents: While its solubility in organic solvents is typically lower, certain polar solvents may still facilitate partial dissolution.
  • Temperature Dependence: An increase in temperature tends to enhance solubility due to the increased kinetic energy of the molecules.

In summary, the solubility of this compound is greatly influenced by the surrounding environment. Understanding these solubility properties is essential for optimizing its use in pharmaceutical formulations and biological applications.

Interesting facts

Interesting Facts about Disodium 2-[[4-[(2,4-Diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]amino]pentanedioate

Disodium 2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]amino]pentanedioate is a fascinating compound that holds significant potential in various scientific fields. Here are some intriguing aspects to consider:

  • Biological Relevance: This compound is particularly noteworthy in the realm of medicinal chemistry. Its structure suggests potential applications in drug design, particularly for targeting specific biological pathways.
  • Structure Complexity: The presence of the 2,4-diaminopteridin moiety indicates a complex arrangement that may contribute to its biological activity, reflecting the intricacies of pharmacophores in drug development.
  • Dual Functionality: The compound includes both amino and benzoyl groups which can enhance its reactivity and interaction with biological molecules, making it a candidate for further studies in enzyme inhibition and receptor binding.
  • Versatile Applications: Beyond its potential medicinal uses, the compound's unique structure may inspire innovative applications in nanotechnology and materials science.

While much is still to be explored regarding the biological mechanisms and possible therapeutic effects of this compound, it serves as an excellent example of how new chemical entities can lead to breakthroughs in science. As one noted researcher quipped, “Every complex molecule is a potential key to unlock the mysteries of biology.”

Thus, disodium 2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]amino]pentanedioate is not just a compound of interest; it represents the endless possibilities that chemical research holds for the future.

Synonyms
Amethopterin (disodium);CL14377 (disodium);WR19039 (disodium)
AKOS015896176
D87624
disodium;2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioate
disodium 2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioate