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Fluticasone propionate

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Identification
Molecular formula
C25H31F2O4S
CAS number
226562-04-9
IUPAC name
disodium;[2-[(6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] phosphate
State
State

Fluticasone propionate is a solid under standard conditions. It is usually handled and processed in its powder form for pharmaceutical applications.

Melting point (Celsius)
273.00
Melting point (Kelvin)
546.15
Boiling point (Celsius)
488.60
Boiling point (Kelvin)
761.75
General information
Molecular weight
500.58g/mol
Molar mass
500.5750g/mol
Density
1.2200g/cm3
Appearence

Fluticasone propionate typically appears as a white to off-white powder. It is known for its fine crystalline consistency, which can sometimes appear slightly creamy to the eye.

Comment on solubility

Solubility of Disodium; [2-[(6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] phosphate

The solubility of this compound is notably dependent on several factors, including its molecular structure and the presence of certain functional groups. Here are some key points regarding its solubility:

  • Ionic Nature: Being a disodium salt, it is likely to exhibit higher solubility in polar solvents such as water due to the ionic interactions with solvent molecules.
  • Functional Groups: The presence of phosphates often increases solubility in aqueous environments.
  • Hydrophobic Regions: The compound also contains a complex hydrophobic structure, which may limit solubility in non-polar solvents.
  • Temperature Influence: Like many compounds, solubility may increase with temperature, allowing for better dissolution in warm conditions.

In summary, while this compound displays promising solubility characteristics due to its ionic and hydrophilic components, challenges may arise from its complex hydrophobic architecture. Therefore, it may be most soluble in environments where water is a dominant solvent, potentially limiting its applicability in non-polar media.

Interesting facts

Interesting Facts about Disodium;[2-[(6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] phosphate

This compound, often referred to as a phosphate derivative, is notable in the field of medicinal chemistry due to its potential therapeutic applications. Here are some intriguing aspects of this chemical:

  • Biological Relevance: Phosphates play a crucial role in various biological processes, including energy transfer (ATP) and signal transduction. This compound may mimic or interrupt pathways that involve phosphates, offering potential as a drug candidate.
  • Stereochemistry: The compound exhibits multiple chiral centers (as indicated by its stereochemical descriptors), which adds complexity to its biological interactions. The arrangement of its substituents can drastically affect its activity and interactions with biological targets.
  • Fluorine Impact: The presence of a fluorine atom, particularly bonded to the steroid-like structure, can enhance metabolic stability and improve the lipophilicity of the compound. This can lead to better absorption and distribution in biological systems.
  • Structure-Activity Relationship (SAR): Understanding how variations in the structure of this compound influence its biological activity is crucial for optimizing potential pharmaceuticals. Researchers often investigate modifications to the phosphate group or the steroid backbone to improve selectivity and efficacy.

The investigation of compounds like this one not only enhances our understanding of how complex organic molecules interact with biological systems but also aids in the design of innovative treatments for various diseases. As stated in one research paper, “The quest for tailored pharmacological effects drives the need for a deeper grasp of structural designs in chemical compounds.”

Future studies may uncover new therapeutic uses or highlight the importance of this compound in drug development, making it an exciting topic for those interested in the intersection of chemistry and biology.

Synonyms
EINECS 218-410-5
805-803-7
PARAMETHASONE DISODIUM PHOSPHATE
2145-14-4
41I31208JK
UNII-41I31208JK
DTXSID10944042
PARAMETHASONE DISODIUM PHOSPHATE [WHO-DD]
Q27258439
Disodium 6-fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl phosphate
PREGNA-1,4-DIENE-3,20-DIONE, 6-FLUORO-11,17-DIHYDROXY-16-METHYL-21-(PHOSPHONOOXY)-, DISODIUM SALT, (6.ALPHA.,11.BETA.,16.ALPHA.)-
Pregna-1,4-diene-3,20-dione, 6-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (6alpha,11beta,16alpha)-